{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:46:44Z","timestamp":1792032404177,"version":"4.4.0"},"reference-count":30,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"15","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2023,5,20]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>Myelodysplastic syndromes (MDS) are heterogeneous myeloid neoplasms in which a risk-adapted treatment strategy is needed. Recently, a new clinical-molecular prognostic model, the Molecular International Prognostic Scoring System (IPSS-M) was proposed to improve the prediction of clinical outcome of the currently available tool (Revised International Prognostic Scoring System [IPSS-R]). We aimed to provide an extensive validation of IPSS-M.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A total of 2,876 patients with primary MDS from the GenoMed4All consortium were retrospectively analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>IPSS-M improved prognostic discrimination across all clinical end points with respect to IPSS-R (concordance was 0.81 v 0.74 for overall survival and 0.89 v 0.76 for leukemia-free survival, respectively). This was true even in those patients without detectable gene mutations. Compared with the IPSS-R based stratification, the IPSS-M risk group changed in 46% of patients (23.6% and 22.4% of subjects were upstaged and downstaged, respectively). In patients treated with hematopoietic stem cell transplantation (HSCT), IPSS-M significantly improved the prediction of the risk of disease relapse and the probability of post-transplantation survival versus IPSS-R (concordance was 0.76 v 0.60 for overall survival and 0.89 v 0.70 for probability of relapse, respectively). In high-risk patients treated with hypomethylating agents (HMA), IPSS-M failed to stratify individual probability of response; response duration and probability of survival were inversely related to IPSS-M risk. Finally, we tested the accuracy in predicting IPSS-M when molecular information was missed and we defined a minimum set of 15 relevant genes associated with high performance of the score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>IPSS-M improves MDS prognostication and might result in a more effective selection of candidates to HSCT. Additional factors other than gene mutations can be involved in determining HMA sensitivity. The definition of a minimum set of relevant genes may facilitate the clinical implementation of the score.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.22.01784","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T16:03:14Z","timestamp":1679068994000},"page":"2827-2842","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":124,"title":["Real-World Validation of Molecular International Prognostic Scoring System for Myelodysplastic Syndromes"],"prefix":"10.1200","volume":"41","clinical-trial-number":[{"clinical-trial-number":"nct04889729","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7830-988X","authenticated-orcid":false,"given":"Elisabetta","family":"Sauta","sequence":"first","affiliation":[{"name":"Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Robin","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation, H\u00f4pital Saint-Louis\/Assistance Publique-H\u00f4pitaux de Paris (AP-HP)\/University Paris 7, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9041-5493","authenticated-orcid":false,"given":"Matteo","family":"Bersanelli","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Travaglino","sequence":"additional","affiliation":[{"name":"Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manja","family":"Meggendorfer","sequence":"additional","affiliation":[{"name":"MLL Munich Leukemia Laboratory, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5035-4470","authenticated-orcid":false,"given":"Lin-Pierre","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation, H\u00f4pital Saint-Louis\/Assistance Publique-H\u00f4pitaux de Paris (AP-HP)\/University Paris 7, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Caballero Berrocal","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario de Salamanca, Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4889-1047","authenticated-orcid":false,"given":"Claudia","family":"Sala","sequence":"additional","affiliation":[{"name":"Experimental, Diagnostic and Specialty Medicine, DIMES, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Maggioni","sequence":"additional","affiliation":[{"name":"Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1334-0851","authenticated-orcid":false,"given":"Massimo","family":"Bernardi","sequence":"additional","affiliation":[{"name":"Hematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Di Grazia","sequence":"additional","affiliation":[{"name":"Hematology and Transplant Center, IRCCS Ospedale Policlinico San Martino, Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4247-3175","authenticated-orcid":false,"given":"Luca","family":"Vago","sequence":"additional","affiliation":[{"name":"Hematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Rivoli","sequence":"additional","affiliation":[{"name":"Hematology and Transplant Center, IRCCS Ospedale Policlinico San Martino, Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenza","family":"Borin","sequence":"additional","affiliation":[{"name":"Hematology, Ospedale San Gerardo, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1877-8497","authenticated-orcid":false,"given":"Saverio","family":"D'Amico","sequence":"additional","affiliation":[{"name":"Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina Astrid","family":"Tentori","sequence":"additional","affiliation":[{"name":"Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Ubezio","sequence":"additional","affiliation":[{"name":"Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Campagna","sequence":"additional","affiliation":[{"name":"Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Russo","sequence":"additional","affiliation":[{"name":"Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1378-6896","authenticated-orcid":false,"given":"Daniele","family":"Mannina","sequence":"additional","affiliation":[{"name":"Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2404-8829","authenticated-orcid":false,"given":"Luca","family":"Lanino","sequence":"additional","affiliation":[{"name":"Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1355-1587","authenticated-orcid":false,"given":"Patrizia","family":"Chiusolo","sequence":"additional","affiliation":[{"name":"Hematology, IRCCS Fondazione Policlinico Universitario Gemelli & Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Giaccone","sequence":"additional","affiliation":[{"name":"Stem Cell Transplant Program, Department of Oncology, A.O.U. Citt\u00e0 della Salute e della Scienza di Torino, Turin, Italy"},{"name":"Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6164-4761","authenticated-orcid":false,"given":"Maria Teresa","family":"Voso","sequence":"additional","affiliation":[{"name":"Hematology, Policlinico Tor Vergata & Department of Biomedicine and Prevention, Tor Vergata University, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Riva","sequence":"additional","affiliation":[{"name":"Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9238-5734","authenticated-orcid":false,"given":"Esther Natalie","family":"Oliva","sequence":"additional","affiliation":[{"name":"Hematology, Grande Ospedale Metropolitano Bianchi Melacrino Morelli, Reggio Calabria, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9952-1142","authenticated-orcid":false,"given":"Matteo","family":"Zampini","sequence":"additional","affiliation":[{"name":"Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0701-3889","authenticated-orcid":false,"given":"Elena","family":"Riva","sequence":"additional","affiliation":[{"name":"Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Nibourel","sequence":"additional","affiliation":[{"name":"Laboratory of Hematology, CHU Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9674-9304","authenticated-orcid":false,"given":"Marilena","family":"Bicchieri","sequence":"additional","affiliation":[{"name":"Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niccolo\u2019","family":"Bolli","sequence":"additional","affiliation":[{"name":"Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy"},{"name":"Department of Oncology and Hemato-Oncology, University of Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3739-7502","authenticated-orcid":false,"given":"Alessandro","family":"Rambaldi","sequence":"additional","affiliation":[{"name":"Hematology, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy"},{"name":"Department of Oncology and Hemato-Oncology, University of Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8068-5289","authenticated-orcid":false,"given":"Francesco","family":"Passamonti","sequence":"additional","affiliation":[{"name":"Hematology, ASST Sette Laghi, Ospedale di Circolo of Varese, Varese, Italy"},{"name":"Department of Medicine and Surgery, University of Insubria, Varese, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Savevski","sequence":"additional","affiliation":[{"name":"Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1709-9492","authenticated-orcid":false,"given":"Armando","family":"Santoro","sequence":"additional","affiliation":[{"name":"Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Germing","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology, and Clinical Immunology, Heinrich-Heine-University, University Clinic, D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0347-4207","authenticated-orcid":false,"given":"Shahram","family":"Kordasti","sequence":"additional","affiliation":[{"name":"Haematology, Guy's Hospital and Comprehensive Cancer Centre, King's College, London, United Kingdom"},{"name":"Hematology Department and Stem Cell Transplant Unit, DISCLIMO-Universit\u00e0 Politecnica delle Marche, Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5439-2172","authenticated-orcid":false,"given":"Valeria","family":"Santini","sequence":"additional","affiliation":[{"name":"Hematology, Azienda Ospedaliero-Universitaria Careggi & University of Florence, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Diez-Campelo","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario de Salamanca, Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2767-8191","authenticated-orcid":false,"given":"Guillermo","family":"Sanz","sequence":"additional","affiliation":[{"name":"Hematology, Hospital Universitario La Fe, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3251-2161","authenticated-orcid":false,"given":"Francesc","family":"Sole","sequence":"additional","affiliation":[{"name":"Institut de Recerca Contra la Leuc\u00e8mia Josep Carreras, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6452-2874","authenticated-orcid":false,"given":"Wolfgang","family":"Kern","sequence":"additional","affiliation":[{"name":"MLL Munich Leukemia Laboratory, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1863-3239","authenticated-orcid":false,"given":"Uwe","family":"Platzbecker","sequence":"additional","affiliation":[{"name":"Medical Clinic and Policlinic 1, Hematology and Cellular Therapy, University Hospital Leipzig, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9020-8766","authenticated-orcid":false,"given":"Lionel","family":"Ades","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation, H\u00f4pital Saint-Louis\/Assistance Publique-H\u00f4pitaux de Paris (AP-HP)\/University Paris 7, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Fenaux","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation, H\u00f4pital Saint-Louis\/Assistance Publique-H\u00f4pitaux de Paris (AP-HP)\/University Paris 7, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Haferlach","sequence":"additional","affiliation":[{"name":"MLL Munich Leukemia Laboratory, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4892-925X","authenticated-orcid":false,"given":"Gastone","family":"Castellani","sequence":"additional","affiliation":[{"name":"Experimental, Diagnostic and Specialty Medicine, DIMES, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6915-5970","authenticated-orcid":false,"given":"Matteo Giovanni","family":"Della Porta","sequence":"additional","affiliation":[{"name":"Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"b1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-03-492884"},{"key":"b2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-03-420489"},{"key":"b3","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.55"},{"key":"b4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.01659"},{"key":"b5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-09-381665"},{"key":"b6","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-08-518886"},{"key":"b7","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-1008-z"},{"key":"b8","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.02810"},{"key":"b9","doi-asserted-by":"publisher","DOI":"10.1056\/EVIDoa2200008"},{"key":"b12","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-643544"},{"key":"b13","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01613-1"},{"key":"b14","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015850"},{"key":"b15","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-10-4149"},{"key":"b16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1541-0420.2007.00868.x"},{"key":"b17","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1982.03320430047030"},{"key":"b18","doi-asserted-by":"publisher","DOI":"10.1109\/TAC.1974.1100705"},{"key":"b19","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3756"},{"key":"b21","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-06-724500"},{"key":"b22","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.67.3616"},{"key":"b23","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1611604"},{"key":"b24","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-01-0338"},{"key":"b25","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.88"},{"key":"b26","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.70.7349"},{"key":"b27","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70003-8"},{"key":"b28","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.283"},{"key":"b29","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.25328"},{"key":"b30","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1605949"},{"key":"b31","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0907109106"},{"key":"b32","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2119771"},{"key":"b33","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6901"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.22.01784","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T18:02:19Z","timestamp":1684346539000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.22.01784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,20]]},"references-count":30,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2023,5,20]]}},"alternative-id":["10.1200\/JCO.22.01784"],"URL":"https:\/\/doi.org\/10.1200\/jco.22.01784","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,20]]},"assertion":[{"value":"2022-08-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}