{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:11:21Z","timestamp":1793211081258,"version":"4.5.0"},"reference-count":18,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"2","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["J Clin Oncol"],"published-print":{"date-parts":[[2024,1,10]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in<\/jats:italic>\n                    JCO\n                    <jats:italic toggle=\"yes\">or elsewhere, for which the primary end point has already been reported.<\/jats:italic>\n                  <\/jats:p>\n                  <jats:p>\n                    Whether adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC) might prevent peritoneal metastases after curative surgery for high-risk colon cancer is an ongoing debate. This study aimed to determine 5-year oncologic outcomes of the randomized multicenter COLOPEC trial, which included patients with clinical or pathologic T4N0-2M0 or perforated colon cancer and randomly assigned (1:1) to either adjuvant systemic chemotherapy and HIPEC (n = 100) or adjuvant systemic chemotherapy alone (n = 102). HIPEC was performed using a one-time administration of oxaliplatin (460 mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    , 30 minutes, 42\u00b0C, concurrent fluorouracil\/leucovorin intravenously), either simultaneously (9%) or within 5-8 weeks (91%) after primary tumor resection. Outcomes were analyzed according to the intention-to-treat principle. Long-term data were available of all 202 patients included in the COLOPEC trial, with a median follow-up of 59 months (IQR, 54.5-64.5). No significant difference was found in 5-year overall survival rate between patients assigned to adjuvant HIPEC followed by systemic chemotherapy or only adjuvant systemic chemotherapy (69.6%\n                    <jats:italic toggle=\"yes\">v<\/jats:italic>\n                    70.9%, log-rank;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .692). Five-year peritoneal metastases-free survival rates were 63.9% and 63.2% (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .907) and 5-year disease-free survival was 55.7% and 52.3% (log-rank;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .875), respectively. No differences in quality-of-life outcomes were found. Our findings implicate that adjuvant HIPEC should still be performed in trial setting only.\n                  <\/jats:p>","DOI":"10.1200\/jco.22.02644","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T15:59:13Z","timestamp":1699027153000},"page":"140-145","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":49,"title":["Adjuvant Hyperthermic Intraperitoneal Chemotherapy in Patients With Locally Advanced Colon Cancer (COLOPEC): 5-Year Results of a Randomized Multicenter Trial"],"prefix":"10.1200","volume":"42","clinical-trial-number":[{"clinical-trial-number":"nct02231086","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9132-0821","authenticated-orcid":false,"given":"Emma Sophia","family":"Zwanenburg","sequence":"first","affiliation":[{"name":"Amsterdam UMC Location University of Amsterdam, Department of Surgery, Amsterdam, the 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