{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T04:00:12Z","timestamp":1793505612694,"version":"4.5.0"},"reference-count":18,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"2","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2024,1,10]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>In patients with peritoneal metastasis (PM) from gastric cancer (GC), chemotherapy is the treatment of choice. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are still being debated. This randomized, controlled, open-label, multicenter phase III trial (EudraCT 2006-006088-22; ClinicalTrials.gov identifier: NCT02158988 ) explored the impact on overall survival (OS) of HIPEC after CRS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PATIENTS AND METHODS<\/jats:title>\n                    <jats:p>\n                      Adult patients with GC and histologically proven PM were randomly assigned (1:1) to perioperative chemotherapy and CRS alone (CRS-A) or CRS plus HIPEC (CRS + H). HIPEC comprised mitomycin C 15 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      and cisplatin 75 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      in 5 L of saline perfused for 60 minutes at 42\u00b0C. The primary end point was OS; secondary endpoints included progression-free survival (PFS), other distant metastasis-free survival (MFS), and safety. Analyses followed the intention-to-treat principle.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Between March 2014 and June 2018, 105 patients were randomly assigned (53 patients to CRS-A and 52 patients to CRS + H). The trial stopped prematurely because of slow recruitment. In 55 patients, treatment stopped before CRS mainly due to disease progression\/death. Median OS was the same for both groups (CRS + H, 14.9 [97.2% CI, 8.7 to 17.7] months v CRS-A, 14.9 [97.2% CI, 7.0 to 19.4] months; P = .1647). The PFS was 3.5 months (95% CI, 3.0 to 7.0) in the CRS-A group and 7.1 months (95% CI, 3.7 to 10.5; P = .047) in the CRS + H group. The CRS + H group showed better MFS (10.2 months [95% CI, 7.7 to 14.7] v CRS-A, 9.2 months [95% CI, 6.8 to 11.5]; P = .0286). The incidence of grade \u22653 adverse events (AEs) was similar between groups (CRS-A, 38.1% v CRS + H, 43.6%; P = .79).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>This study showed no OS difference between CRS + H and CRS-A. PFS and MFS were significantly better in the CRS + H group, which needs further exploration. HIPEC did not increase AEs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.22.02867","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T15:59:14Z","timestamp":1698767954000},"page":"146-156","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":150,"title":["Effect of Hyperthermic Intraperitoneal Chemotherapy on Cytoreductive Surgery in Gastric Cancer With Synchronous Peritoneal Metastases: The Phase III GASTRIPEC-I Trial"],"prefix":"10.1200","volume":"42","clinical-trial-number":[{"clinical-trial-number":"nct02158988","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5820-6907","authenticated-orcid":false,"given":"Beate","family":"Rau","sequence":"first","affiliation":[{"name":"Department of Surgery, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hauke","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Johannes Gutenberg Universit\u00e4t Mainz Klinikum, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred","family":"Koenigsrainer","sequence":"additional","affiliation":[{"name":"Department of Surgery, Universit\u00e4tsklinikum T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7423-713X","authenticated-orcid":false,"given":"Ines","family":"Gockel","sequence":"additional","affiliation":[{"name":"Department of Surgery, Universit\u00e4tsklinikum Leipzig, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9967-744X","authenticated-orcid":false,"given":"Horst-Guenter","family":"Rau","sequence":"additional","affiliation":[{"name":"Emeritus Department of Surgery, Amper Kliniken AG, Dachau, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5937-052X","authenticated-orcid":false,"given":"Hendrik","family":"Seeliger","sequence":"additional","affiliation":[{"name":"Department of Surgery, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Lerchenmueller","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Gemeinschaftspraxis f\u00fcr H\u00e4matologie und Onkologie\u2014M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Reim","sequence":"additional","affiliation":[{"name":"Department of Surgery, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0037-8620","authenticated-orcid":false,"given":"Roger","family":"Wahba","sequence":"additional","affiliation":[{"name":"Department of General, Visceral, Cancer and Transplantation Surgery, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Angele","sequence":"additional","affiliation":[{"name":"Department of Surgery, Klinikum der Universit\u00e4t M\u00fcnchen\u2014Gro\u00dfhadern, M\u00fcnchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3368-0703","authenticated-orcid":false,"given":"Steffen","family":"Heeg","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Medical Center\u2014University of Freiburg, Faculty of Medicine, University of Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Keck","sequence":"additional","affiliation":[{"name":"Department of Surgery, Campus L\u00fcbeck, Universit\u00e4tsklinikum Schleswig-Holstein, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5474-2171","authenticated-orcid":false,"given":"Arved","family":"Weimann","sequence":"additional","affiliation":[{"name":"Department of Surgery, St Georg-Krankenhaus Leipzig, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Topp","sequence":"additional","affiliation":[{"name":"Department of Surgery, Bonifatius Hospital Lingen (f\u00fcr D\u00fcsseldorf), Lingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pompiliu","family":"Piso","sequence":"additional","affiliation":[{"name":"Department of Surgery, Krankenhaus Barmherzige Br\u00fcder Regensburg, Regensburg, 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