{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:49:42Z","timestamp":1792050582186,"version":"4.4.0"},"reference-count":48,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"16","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2024,6,1]]},"abstract":"<jats:sec><jats:title>PURPOSE<\/jats:title><jats:p> There are no well-established re-treatment options for local recurrence after primary curative radiation therapy for prostate cancer (PCa), as prospective studies with long-term follow-up are lacking. Here, we present results from a prospective study on focal salvage reirradiation with external-beam radiation therapy with a median follow-up of 7.2 years. <\/jats:p><\/jats:sec><jats:sec><jats:title>MATERIALS AND METHODS<\/jats:title><jats:p> From 2013 to 2017, 38 patients with biopsy-proven locally recurrent PCa &gt;2 years after previous treatment and absence of grade 2-3 toxicity from the first course of radiation were included. The treatment was 35 Gy in five fractions to the MRI-based target volume and 6 months of androgen-deprivation therapy starting 3 months before radiation. The Phoenix criteria defined biochemical recurrence-free survival (bRFS), and toxicity was scored according to Radiation Therapy Oncology Group criteria. <\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p> Median age was 70 years, and median time from primary radiation to prostate-specific antigen (PSA) recurrence was 83 months. The actuarial 2-year and 5-year bRFS were 81% (95% CI, 69 to 94) and 58% (95% CI, 49 to 74), respectively. The actuarial 5-year local recurrence-free survival was 93% (95% CI, 82 to 100), metastasis-free survival was 82% (95% CI, 69 to 95), and overall survival was 87% (95% CI, 76 to 98). Two patients (5%) had durable grade 3 genitourinary toxicity, one combined with GI grade 3 toxicity. A PSA doubling time \u22646 months at salvage, a Gleason score &gt;7, and a PSA nadir \u22650.1 ng\/mL predicted a worse outcome. <\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p> Reirradiation with EBRT for locally recurrent PCa after primary curative radiation therapy is clinically feasible and demonstrated a favorable outcome with acceptable toxicity in this prospective study with long-term follow-up. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.23.01391","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T20:00:00Z","timestamp":1713902400000},"page":"1934-1942","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":31,"title":["Salvage Reirradiation for Locally Recurrent Prostate Cancer: Results From a Prospective Study With 7.2 Years of Follow-Up"],"prefix":"10.1200","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6526-7174","authenticated-orcid":false,"given":"Christian","family":"Ekanger","sequence":"first","affiliation":[{"name":"Department of Oncology and Medical Physics, Haukeland University Hospital, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svein Inge","family":"Helle","sequence":"additional","affiliation":[{"name":"Department of Oncology and Medical Physics, Haukeland University Hospital, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Reis\u00e6ter","sequence":"additional","affiliation":[{"name":"Department of Radiology, Haukeland University Hospital, Bergen, Norway"},{"name":"Department of Clinical Medicine, University of Bergen, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7593-7549","authenticated-orcid":false,"given":"Liv Bolstad","family":"Hysing","sequence":"additional","affiliation":[{"name":"Department of Oncology and Medical Physics, Haukeland University Hospital, Bergen, Norway"},{"name":"Department of Technology and Physics, Faculty of Mathematics and Natural Sciences, University of Bergen, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4106-230X","authenticated-orcid":false,"given":"Rune","family":"Kv\u00e5le","sequence":"additional","affiliation":[{"name":"Department of Oncology and Medical Physics, Haukeland University Hospital, Bergen, Norway"},{"name":"Department of Research, Cancer Registry of Norway, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0420-2585","authenticated-orcid":false,"given":"Alfred","family":"Honor\u00e9","sequence":"additional","affiliation":[{"name":"Department of Urology, Haukeland University Hospital, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5914-0515","authenticated-orcid":false,"given":"Karsten","family":"Gravdal","sequence":"additional","affiliation":[{"name":"Department of Patohology, Haukeland University Hospital, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Pilskog","sequence":"additional","affiliation":[{"name":"Department of Oncology and Medical Physics, Haukeland University Hospital, Bergen, Norway"},{"name":"Department of Technology and Physics, Faculty of Mathematics and Natural Sciences, University of Bergen, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olav","family":"Dahl","sequence":"additional","affiliation":[{"name":"Department of Oncology and Medical Physics, Haukeland University Hospital, Bergen, Norway"},{"name":"Department of Clinical Science, University of Bergen, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"b1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"b2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.09.042"},{"key":"b3","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.06.100"},{"key":"b4","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2019.11.007"},{"key":"b5","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2022.07.011"},{"key":"b6","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2013.12.014"},{"key":"b7","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-018-2406-4"},{"key":"b8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2012.11774.x"},{"key":"b9","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28446"},{"key":"b10","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.09.046"},{"key":"b11","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000327"},{"key":"b12","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-022-04031-1"},{"key":"b13","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.03.031"},{"key":"b15","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000002758"},{"key":"b16","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol28040252"},{"key":"b17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2019.10.014"},{"key":"b18","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.11.010"},{"key":"b19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2020.07.014"},{"key":"b20","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.681448"},{"key":"b21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2011.10112.x"},{"key":"b22","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70380-8"},{"key":"b23","first-page":"1121","volume":"11","author":"Delgado A","year":"2021","journal-title":"Am J Cancer Res"},{"key":"b24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.04.029"},{"key":"b25","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(95)00060-C"},{"key":"b26","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(96)00075-X"},{"key":"b27","volume-title":"Modelling of bladder motion and investigation of correlation with toxicity in re-irradiation of prostate cancer [master thesis]","author":"Thu S","year":"2023"},{"key":"b28","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.2906"},{"key":"b29","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000124381.93689.b4"},{"key":"b30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.03.008"},{"key":"b31","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djg043"},{"key":"b32","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.10.011"},{"key":"b33","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2017.07.013"},{"key":"b34","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-8-170"},{"key":"b35","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.12.017"},{"key":"b36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2011.10422.x"},{"key":"b37","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2019.08.002"},{"key":"b38","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2023.41.16_suppl.5002"},{"key":"b39","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.02.2571"},{"key":"b40","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.08.005"},{"key":"b41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.10.042"},{"key":"b42","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2018.05.001"},{"key":"b43","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2023.109544"},{"key":"b44","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.09.028"},{"key":"b45","doi-asserted-by":"publisher","DOI":"10.1038\/ncpuro1296"},{"key":"b46","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13397"},{"key":"b47","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2020.01.002"},{"key":"b48","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2022.02.022"},{"key":"b49","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju132"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.23.01391","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T22:01:17Z","timestamp":1717020077000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.23.01391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,1]]},"references-count":48,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2024,6,1]]}},"alternative-id":["10.1200\/JCO.23.01391"],"URL":"https:\/\/doi.org\/10.1200\/jco.23.01391","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,1]]},"assertion":[{"value":"2023-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-24","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}