{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T11:04:24Z","timestamp":1793963064672,"version":"4.8.0"},"reference-count":37,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"19","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>Locally advanced, unresectable basal cell carcinoma (LA BCC) can be treated with radiation therapy (RT), but locoregional control (LRC) rates are unsatisfactory. Vismodegib is a hedgehog pathway inhibitor (HPI) active in BCC that may radiosensitize BCC. We evaluated the combination of vismodegib and RT for patients with LA BCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>In this multicenter, single-arm, phase II study, patients with unresectable LA BCC received 12 weeks of induction vismodegib, followed by 7 weeks of concurrent vismodegib and RT. The primary end point was LRC rate at 1 year after the end of treatment. Secondary end points included objective response, progression-free survival (PFS), overall survival (OS), safety, and patient-reported quality of life (PRQOL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Twenty-four patients received vismodegib; five were unable to complete 12 weeks of induction therapy. LRC was achieved in 91% (95% CI, 68 to 98) of patients at 1 year. The response rate was 63% (95% CI, 38 to 84) after induction vismodegib and 83% (95% CI, 59 to 96) after concurrent vismodegib and RT. With a median follow-up of 5.7 years, 1-year PFS and OS rates were 100% and 96%, and at 5 years PFS and OS rates were 78% and 83%, respectively. Distant metastasis or BCC-related death has not been observed. The most frequent treatment-related adverse events (AEs) were dysgeusia, fatigue, and myalgias occurring in 83%, 75%, and 75% of patients. No grade 4 to 5 treatment-related AEs occurred. PRQOL demonstrated clinically meaningful improvements in all subscales, with emotions and functioning improvements persisting for a year after the end of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>In patients with unresectable LA BCC, the combination of vismodegib and RT yielded high rates of LRC and PFS and durable improvements in PRQOL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.23.01708","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T16:00:28Z","timestamp":1713369628000},"page":"2327-2335","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":20,"title":["Phase II, Single-Arm Trial of Induction and Concurrent Vismodegib With Curative-Intent Radiation Therapy for Locally Advanced, Unresectable Basal Cell Carcinoma"],"prefix":"10.1200","volume":"42","clinical-trial-number":[{"clinical-trial-number":"nct01835626","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Christopher A.","family":"Barker","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6316-6548","authenticated-orcid":false,"given":"Suzanne","family":"Dufault","sequence":"additional","affiliation":[{"name":"Department of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5669-0627","authenticated-orcid":false,"given":"Sarah T.","family":"Arron","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of California San Francisco, San Francisco, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6885-3742","authenticated-orcid":false,"given":"Alan L.","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6576-4659","authenticated-orcid":false,"given":"Alain P.","family":"Algazi","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Francisco, San Francisco, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara A.","family":"Dunn","sequence":"additional","affiliation":[{"name":"Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9812-9432","authenticated-orcid":false,"given":"Audrey A.","family":"Humphries","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of California San Francisco, San Francisco, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carter","family":"Hultman","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of California San Francisco, San Francisco, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Lian","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Daniel","family":"Knott","sequence":"additional","affiliation":[{"name":"Department of Department of Otolaryngology\u2014Head and Neck Surgery, University of California San Francisco, San Francisco, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0779-7476","authenticated-orcid":false,"given":"Sue S.","family":"Yom","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of California San Francisco, San Francisco, CA"},{"name":"Department of Department of Otolaryngology\u2014Head and Neck Surgery, University of California San Francisco, San Francisco, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"b1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1708701"},{"key":"b2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19809"},{"key":"b3","doi-asserted-by":"publisher","DOI":"10.1016\/j.prro.2019.10.014"},{"key":"b4","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(87)90034-4"},{"key":"b5","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1991.01680100068006"},{"key":"b6","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2016.1274365"},{"key":"b7","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.07.018"},{"key":"b8","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15728"},{"key":"b9","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2018.3448"},{"key":"b10","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19092485"},{"key":"b11","doi-asserted-by":"publisher","DOI":"10.1038\/34201"},{"key":"b12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1113713"},{"key":"b13","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3286-5"},{"key":"b14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2014.12.006"},{"key":"b15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.09.075"},{"key":"b16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.01.052"},{"key":"b17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.11.032"},{"key":"b18","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.0326"},{"key":"b19","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13748"},{"key":"b20","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-015-0902-7"},{"key":"b21","doi-asserted-by":"publisher","DOI":"10.1016\/j.currproblcancer.2021.100736"},{"key":"b22","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2021.2208"},{"key":"b23","doi-asserted-by":"publisher","DOI":"10.1002\/onco.13959"},{"key":"b24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.05.020"},{"key":"b25","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17623"},{"key":"b26","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-0176"},{"key":"b27","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-007-9078-9"},{"key":"b28","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-006-0227-4"},{"key":"b29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.01.003"},{"key":"b30","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-12-1030"},{"key":"b31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065032"},{"key":"b32","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2013.1605"},{"key":"b33","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-1346"},{"key":"b34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.10.014"},{"key":"b35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2006.03108.x"},{"key":"b36","doi-asserted-by":"publisher","DOI":"10.1016\/S0007-1226(71)80042-5"},{"key":"b37","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3525"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.23.01708","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T18:00:36Z","timestamp":1719424836000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.23.01708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,1]]},"references-count":37,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2024,7,1]]}},"alternative-id":["10.1200\/JCO.23.01708"],"URL":"https:\/\/doi.org\/10.1200\/jco.23.01708","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,1]]},"assertion":[{"value":"2023-08-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-17","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}