{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:23:53Z","timestamp":1791919433637,"version":"4.3.4"},"reference-count":19,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"31","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n            <jats:title>PURPOSE<\/jats:title>\n            <jats:p>\n              The KUNPENG study aimed to evaluate the efficacy and safety of vebreltinib (also known as bozitinib, APL-101, PLB-1001, and CBT-101), a potent and highly selective inhibitor of c-mesenchymal-epithelial transition (\n              <jats:italic>MET<\/jats:italic>\n              ), in patients with locally advanced or metastatic non\u2013small cell lung cancer (NSCLC) harboring c-Met alterations.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS<\/jats:title>\n            <jats:p>\n              This multicenter, multicohort, open-label, single-arm, phase II trial enrolled patients with c-Met dysregulated, locally advanced or metastatic NSCLC from January 2020 to August 2022 across 17 centers. Cohort 1 included patients with\n              <jats:italic>MET<\/jats:italic>\n              exon 14 skipping (\n              <jats:italic>MET<\/jats:italic>\n              ex14)\u2013mutant NSCLC who had not previously received\n              <jats:italic>MET<\/jats:italic>\n              inhibitors. Participants were administered vebreltinib at a dosage of 200 mg twice a day in 28-day cycles. The primary end point was the objective response rate (ORR), and the key secondary end point was the duration of response (DoR), both evaluated by a blinded independent review committee according to the RECIST version 1.1.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>As of August 9, 2022, 52 patients had been enrolled in cohort 1, of whom 35 (67.3%) were treatment-na\u00efve. The ORR reached 75% (95% CI, 61.1 to 86). Among treatment-na\u00efve patients, the ORR was 77.1% (95% CI, 59.9 to 89.6), and in previously treated patients, it was 70.6% (95% CI, 44.0 to 89.7). The disease control rate was 96.2%, with a median DoR of 15.9 months, a median progression-free survival of 14.1 months, and a median overall survival of 20.7 months. The most common treatment-related adverse events were peripheral edema (82.7%), QT prolongation (30.8%), and elevated serum creatinine (28.8%).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION<\/jats:title>\n            <jats:p>\n              Vebreltinib has shown promising efficacy and a favorable safety profile in patients with\n              <jats:italic>MET<\/jats:italic>\n              ex14-mutant NSCLC.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1200\/jco.23.02363","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T20:03:20Z","timestamp":1722024200000},"page":"3680-3691","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":38,"title":["Vebreltinib for Advanced Non\u2013Small Cell Lung Cancer Harboring c-Met Exon 14 Skipping Mutation: A Multicenter, Single-Arm, Phase II KUNPENG Study"],"prefix":"10.1200","volume":"42","clinical-trial-number":[{"clinical-trial-number":"nct04258033","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0084-3908","authenticated-orcid":false,"given":"Jin-Ji","family":"Yang","sequence":"first","affiliation":[{"name":"Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8738-2053","authenticated-orcid":false,"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China"},{"name":"Division of Thoracic Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7078-7767","authenticated-orcid":false,"given":"Lin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medical Oncology, Hunan Cancer Hospital, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Hu","sequence":"additional","affiliation":[{"name":"Pulmonary and Critical Care Medicine, Zhongshan Hospital Affiliated to Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe-Hai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Hua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Shenzhen People's Hospital, Jinan University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine-Oncology, Fujian Cancer Hospital and Fujian Medical University Cancer Hospital, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7813-2885","authenticated-orcid":false,"given":"Qi-Ming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory, The Affiliated Cancer Hospital of Zhengzhou University &amp; Henan Cancer Hospital, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing), Department of Thoracic Oncology, Peking University Cancer Hospital &amp; Institute, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Lung Cancer, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Lung Cancer, Peking University Cancer Hospital &amp; Institute, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Lung Cancer, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9908-597X","authenticated-orcid":false,"given":"Ying","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Lung Cancer, Jilin Cancer Hospital, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4475-8617","authenticated-orcid":false,"given":"Ren-Hua","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Lung Cancer, Jiangsu Provincial People's Hospital Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-Ya","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He-Peng","family":"Shi","sequence":"additional","affiliation":[{"name":"Beijing Pearl Biotechnology Co, Ltd, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Zhe","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Clinical Operation, Beijing Pearl Biotechnology Co, Ltd, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4901-9203","authenticated-orcid":false,"given":"Di","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Medicine, Beijing Pearl Biotechnology Co, Ltd, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Long","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Pearl Biotechnology Co, Ltd, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3611-0258","authenticated-orcid":false,"given":"Yi-Long","family":"Wu","sequence":"additional","affiliation":[{"name":"Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_9_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.01626"},{"key":"e_1_3_9_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature25183"},{"key":"e_1_3_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2020.08.004"},{"key":"e_1_3_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2016.10.014"},{"key":"e_1_3_9_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000620"},{"key":"e_1_3_9_7_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-2061"},{"key":"e_1_3_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.101952"},{"key":"e_1_3_9_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2002787"},{"key":"e_1_3_9_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2004407"},{"key":"e_1_3_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00084-9"},{"key":"e_1_3_9_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2023.1962"},{"key":"e_1_3_9_13_2","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.AM2017-2096"},{"key":"e_1_3_9_14_2","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.AM2020-CT127"},{"key":"e_1_3_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.09.038"},{"key":"e_1_3_9_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0178676"},{"key":"e_1_3_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2017.04.015"},{"key":"e_1_3_9_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-023-10217-7"},{"key":"e_1_3_9_19_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.63.4600"},{"key":"e_1_3_9_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyab072"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.23.02363","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T21:59:29Z","timestamp":1730239169000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.23.02363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":19,"journal-issue":{"issue":"31","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1200\/JCO.23.02363"],"URL":"https:\/\/doi.org\/10.1200\/jco.23.02363","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"2023-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-23","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}