{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:25:29Z","timestamp":1789140329245,"version":"build-2803163510"},"reference-count":39,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"33","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2024,11,20]]},"abstract":"<jats:sec>\n            <jats:title>PURPOSE<\/jats:title>\n            <jats:p>\n              NRG-RTOG0617 demonstrated a detrimental effect of uniform high-dose radiation in stage III non\u2013small cell lung cancer. NRG-RTOG1106\/ECOG-ACRIN6697 (ClinicalTrials.gov identifier:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT01507428\">NCT01507428<\/jats:ext-link>\n              ), a randomized phase II trial, studied whether midtreatment\n              <jats:sup>18<\/jats:sup>\n              F-fluorodeoxyglucose positron emission tomography\/computed tomography (FDG-PET\/CT) can guide individualized\/adaptive dose-intensified radiotherapy (RT) to improve and predict outcomes in patients with this disease.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>MATERIALS AND METHODS<\/jats:title>\n            <jats:p>\n              Patients fit for concurrent chemoradiation were randomly assigned (1:2) to standard (60 Gy\/30 fractions) or FDG-PET\u2013guided adaptive treatment, stratified by substage, primary tumor size, and histology. All patients had midtreatment FDG-PET\/CT; adaptive arm patients had an individualized, intensified boost RT dose to residual metabolically active areas. The primary therapeutic end point was 2-year centrally reviewed freedom from local-regional progression (FFLP), defined as no progression in or near the planning target volume and\/or regional nodes. FFLP was analyzed on a modified intent-to-treat population at a one-sided\n              <jats:italic>Z<\/jats:italic>\n              -test significance level of 0.15. The primary imaging end point was centrally reviewed change in SUV\n              <jats:sub>peak<\/jats:sub>\n              from baseline to midtreatment; its association with FFLP was assessed using the two-sided Wald test on the basis of Cox regression.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>\n              Of 138 patients enrolled, 127 were eligible. Adaptive-arm patients received a mean 71 Gy in 30 fractions, with mean lung dose 17.9 Gy. There was no significant difference in centrally reviewed 2-year FFLP (59.5% and 54.6% in standard and adaptive arms;\n              <jats:italic>P<\/jats:italic>\n              = .66). There were no significant differences in protocol-specified grade 3 toxicities, survival, or progression-free survival (\n              <jats:italic>P<\/jats:italic>\n              &gt; .4). Median SUV\n              <jats:sub>peak<\/jats:sub>\n              and metabolic tumor volume (MTV) in the adaptive arm decreased 49% and 54%, from pre-RT to mid-RT PET. However, \u0394SUV\n              <jats:sub>peak<\/jats:sub>\n              and \u0394MTV were not associated with FFLP (hazard ratios, 0.997;\n              <jats:italic>P<\/jats:italic>\n              = .395 and .461).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION<\/jats:title>\n            <jats:p>Midtreatment PET-adapted RT dose escalation as given in this study was safe and feasible but did not improve efficacy outcomes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1200\/jco.24.00022","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T19:59:24Z","timestamp":1728071964000},"page":"3935-3946","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":45,"title":["Primary Results of NRG-RTOG1106\/ECOG-ACRIN 6697: A Randomized Phase II Trial of Individualized Adaptive (chemo)Radiotherapy Using Midtreatment\n            <sup>18<\/sup>\n            F-Fluorodeoxyglucose Positron Emission Tomography\/Computed Tomography in Stage III Non\u2013Small Cell Lung Cancer"],"prefix":"10.1200","volume":"42","clinical-trial-number":[{"clinical-trial-number":"nct01507428","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2652-098X","authenticated-orcid":true,"given":"Feng-Ming (Spring)","family":"Kong","sequence":"first","affiliation":[{"name":"University of Hong Kong Shenzhen Hospital, The University of Hong Kong, Shenzhen\/Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4672-1981","authenticated-orcid":true,"given":"Chen","family":"Hu","sequence":"additional","affiliation":[{"name":"NRG Oncology Statistics and Data Management Center, Philadelphia, PA"},{"name":"John Hopkins University, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8978-4419","authenticated-orcid":true,"given":"Daniel A.","family":"Pryma","sequence":"additional","affiliation":[{"name":"University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5084-0070","authenticated-orcid":true,"given":"Fenghai","family":"Duan","sequence":"additional","affiliation":[{"name":"US and ECOG-ACRIN Biostatistics Center, Brown University, Providence, RI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Matuszak","sequence":"additional","affiliation":[{"name":"University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8558-6394","authenticated-orcid":true,"given":"Ying","family":"Xiao","sequence":"additional","affiliation":[{"name":"University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall","family":"Ten Haken","sequence":"additional","affiliation":[{"name":"University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8342-8293","authenticated-orcid":true,"given":"Marilyn J.","family":"Siegel","sequence":"additional","affiliation":[{"name":"Mallinckrodt Institute of Radiology and Siteman Cancer Center at Washington University, Saint Louis, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Hanna","sequence":"additional","affiliation":[{"name":"US and ECOG-ACRIN Biostatistics Center, Brown University, Providence, RI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter J.","family":"Curran","sequence":"additional","affiliation":[{"name":"Piedmont Cancer Institute, Atlanta, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Dunphy","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphna","family":"Gelblum","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering, West Harrison, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3767-5648","authenticated-orcid":true,"given":"Morand","family":"Piert","sequence":"additional","affiliation":[{"name":"University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8174-5199","authenticated-orcid":true,"given":"Shruti","family":"Jolly","sequence":"additional","affiliation":[{"name":"University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1399-9904","authenticated-orcid":true,"given":"Clifford G.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Mallinckrodt Institute of Radiology and Siteman Cancer Center at Washington University, Saint Louis, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Quon","sequence":"additional","affiliation":[{"name":"US (Accrual for Stanford University), University of California Los Angeles, Los Angeles, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2521-0544","authenticated-orcid":true,"given":"Billy W.","family":"Loo","sequence":"additional","affiliation":[{"name":"Stanford University, Stanford, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyam","family":"Srinivas","sequence":"additional","affiliation":[{"name":"US (Accruals for CWRU Case Comprehensive Cancer Center), University of Pittsburgh Medical Center, Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6276-1505","authenticated-orcid":true,"given":"Gregory M.","family":"Videtic","sequence":"additional","affiliation":[{"name":"US (Accrual for CWRU Case Comprehensive Cancer Center), Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio L.","family":"Faria","sequence":"additional","affiliation":[{"name":"McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5949-6333","authenticated-orcid":true,"given":"Catherine","family":"Ferguson","sequence":"additional","affiliation":[{"name":"US (Accrual for Georgia Cares Minority Underserved), Augusta University Medical Center, Augusta, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal E.","family":"Dunlap","sequence":"additional","affiliation":[{"name":"The James Graham Brown Cancer Center at University of Louisville, Louisville, KY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2402-2154","authenticated-orcid":true,"given":"Vijayananda","family":"Kundapur","sequence":"additional","affiliation":[{"name":"Saskatoon Cancer Centre, Saskatoon, SK, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7312-1194","authenticated-orcid":true,"given":"Rebecca","family":"Paulus","sequence":"additional","affiliation":[{"name":"NRG Oncology Statistics and Data Management Center, Philadelphia, PA"},{"name":"American College of Radiology, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6246-5792","authenticated-orcid":true,"given":"Barry A.","family":"Siegel","sequence":"additional","affiliation":[{"name":"Mallinckrodt Institute of Radiology and Siteman Cancer Center at Washington University, Saint Louis, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9305-7396","authenticated-orcid":true,"given":"Jeffrey D.","family":"Bradley","sequence":"additional","affiliation":[{"name":"University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8675-9334","authenticated-orcid":true,"given":"Mitchell","family":"Machtay","sequence":"additional","affiliation":[{"name":"Penn State University and Cancer Institute, Milton S Hershey Medical Center, Hershey, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_11_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1809697"},{"key":"e_1_3_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30896-9"},{"key":"e_1_3_11_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(99)00087-0"},{"key":"e_1_3_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.09.004"},{"key":"e_1_3_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.02.010"},{"key":"e_1_3_11_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.27.1205"},{"key":"e_1_3_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.06.1935"},{"key":"e_1_3_11_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)71207-0"},{"key":"e_1_3_11_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.47.5947"},{"key":"e_1_3_11_11_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.10.3747"},{"key":"e_1_3_11_12_2","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2012.13.1.319"},{"key":"e_1_3_11_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.0982"},{"key":"e_1_3_11_14_2","doi-asserted-by":"crossref","unstructured":"Scheuermann JS Saffer JR Karp JS et al: Qualification of PET scanners for use in multicenter cancer clinical trials: The American College of Radiology Imaging Network experience. J Nucl Med 50:1187-1193 2009","DOI":"10.2967\/jnumed.108.057455"},{"key":"e_1_3_11_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.09.033"},{"key":"e_1_3_11_16_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.149"},{"key":"e_1_3_11_17_2","unstructured":"National Cancer Institute Cancer Therapy Evaluation Program: Common Terminology Criteria for Adverse Events (CTCAE) v4.0. 2010. https:\/\/ctep.cancer.gov\/protocoldevelopment\/electronic_applications\/ctc.htm#ctc_40"},{"key":"e_1_3_11_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2018.11.028"},{"key":"e_1_3_11_19_2","unstructured":"The R Project for Statistical Computing. https:\/\/www.r-project.org\/"},{"key":"e_1_3_11_20_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.108.057307"},{"key":"e_1_3_11_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2015.07.024"},{"key":"e_1_3_11_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2020.07.2070"},{"key":"e_1_3_11_23_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13246193"},{"key":"e_1_3_11_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.10.054"},{"key":"e_1_3_11_25_2","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2015.1061209"},{"key":"e_1_3_11_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.01.067"},{"key":"e_1_3_11_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2009.11.003"},{"key":"e_1_3_11_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.12.027"},{"key":"e_1_3_11_29_2","first-page":"126","article-title":"Dose escalation for unresectable locally advanced non-small cell lung cancer: End of the line?","volume":"5","author":"Hong JC","year":"2016","unstructured":"Hong JC, Salama JK: Dose escalation for unresectable locally advanced non-small cell lung cancer: End of the line? Transl Lung Cancer Res 5:126-133, 2016","journal-title":"Transl Lung Cancer Res"},{"key":"e_1_3_11_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/mp.12308"},{"key":"e_1_3_11_31_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20140234"},{"key":"e_1_3_11_32_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23849"},{"key":"e_1_3_11_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30013-9"},{"key":"e_1_3_11_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2018.09.019"},{"key":"e_1_3_11_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2023.109492"},{"key":"e_1_3_11_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2023.06.288"},{"key":"e_1_3_11_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"key":"e_1_3_11_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-019-04388-3"},{"key":"e_1_3_11_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-017-3762-9"},{"key":"e_1_3_11_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2018.10.006"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.24.00022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T23:00:05Z","timestamp":1731711605000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.24.00022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,20]]},"references-count":39,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2024,11,20]]}},"alternative-id":["10.1200\/JCO.24.00022"],"URL":"https:\/\/doi.org\/10.1200\/jco.24.00022","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,20]]},"assertion":[{"value":"2024-01-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-15","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}