{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:28:28Z","timestamp":1770816508131,"version":"3.50.1"},"reference-count":33,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"28","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n            <jats:title>PURPOSE<\/jats:title>\n            <jats:p>There have been no previous longitudinal assessments of health-related quality of life (HRQoL) during treatment for pediatric Hodgkin lymphoma (HL). The addition of brentuximab vedotin (BV) to a multidrug chemotherapy backbone demonstrated superior efficacy to standard chemotherapy for patients with pediatric high-risk HL in the AHOD 1331 trial. However, the impact on HRQoL is unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>PATIENTS AND METHODS<\/jats:title>\n            <jats:p>After treatment random assignment, 268 participants older than 11 years were enrolled in a prespecified, longitudinal, patient-reported outcomes substudy. HRQoL was assessed using the seven-item Child Health Ratings Inventories (CHRIs)\u2013Global scale before treatment (T1) and at cycle 2 (T2), cycle 5 (T3), and end of treatment (T4). A clinically meaningful increase in HRQoL was considered 7 points on the CHRIs-Global. Multivariable linear regression estimated associations between demographic\/clinical variables and HRQoL at T1. Linear mixed models estimated changes in HRQoL across the treatment arm.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>\n              Participant characteristics were balanced by treatment arm. Ninety-three percent of participants completed the CHRIs at T1, 92% at T2, 89% at T3, and 77% at T4. At T1, female sex and fever (\n              <jats:italic>P<\/jats:italic>\n              &lt; .05) were each associated with worse HRQoL. By T2, participants in the BV arm experienced a statistically and clinically significant improvement in HRQoL (\u03b2 = 7.3 [95% CI, 3.2 to 11.4];\n              <jats:italic>P<\/jats:italic>\n              \u2264 .001), which was greater than the change in the standard arm (difference in change \u03b2 = 5.1 [95% CI, \u22120.2 to 10.3];\n              <jats:italic>P<\/jats:italic>\n              = .057). The standard arm did not experience a statistically or clinically significant increase in HRQoL until T4 (\u03b2 = 9.3 [95% CI, 4.7 to 11.5];\n              <jats:italic>P<\/jats:italic>\n              &lt; .001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION<\/jats:title>\n            <jats:p>These data demonstrate successful collection of serial HRQoL from youth with high-risk pediatric HL and improvement in HRQoL over the course of initial therapy, sooner and to a greater extent in the group receiving the novel agent BV.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1200\/jco.24.00038","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T20:02:46Z","timestamp":1722024166000},"page":"3330-3338","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":5,"title":["Longitudinal Health-Related Quality of Life Among Patients With High-Risk Pediatric Hodgkin Lymphoma Treated on the Children's Oncology Group AHOD 1331 Study"],"prefix":"10.1200","volume":"42","clinical-trial-number":[{"clinical-trial-number":"nct02166463","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7042-5851","authenticated-orcid":false,"given":"AnnaLynn M.","family":"Williams","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Supportive Care in Cancer, University of Rochester Medical Center, Rochester, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8671-3401","authenticated-orcid":false,"given":"Angie Mae","family":"Rodday","sequence":"additional","affiliation":[{"name":"Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinglin","family":"Pei","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Florida, Gainesville, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9394-6206","authenticated-orcid":false,"given":"Tara O.","family":"Henderson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Chicago Pritzker School of Medicine, Comer Children's Hospital, Chicago, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8919-467X","authenticated-orcid":false,"given":"Frank G.","family":"Keller","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Emory University School of Medicine, Atlanta, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Punnett","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Hospital for Sick Children and University of Toronto, Toronto, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1473-3937","authenticated-orcid":false,"given":"Kara M.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Roswell Park Comprehensive Cancer Center, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon M.","family":"Castellino","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Emory University School of Medicine, Atlanta, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0282-6490","authenticated-orcid":false,"given":"Susan K.","family":"Parsons","sequence":"additional","affiliation":[{"name":"Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","reference":[{"key":"e_1_3_10_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-013-2114-y"},{"key":"e_1_3_10_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.21.1433"},{"key":"e_1_3_10_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021013167"},{"key":"e_1_3_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70258-X"},{"key":"e_1_3_10_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.01.044"},{"key":"e_1_3_10_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.03160"},{"key":"e_1_3_10_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-016-0515-6"},{"key":"e_1_3_10_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30215-7"},{"key":"e_1_3_10_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-278796"},{"key":"e_1_3_10_11_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.03681"},{"key":"e_1_3_10_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206660"},{"key":"e_1_3_10_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s41687-023-00653-0"},{"key":"e_1_3_10_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-005-1004-2"},{"key":"e_1_3_10_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.11.018"},{"key":"e_1_3_10_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30790-9"},{"key":"e_1_3_10_17_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.3324"},{"key":"e_1_3_10_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32765"},{"key":"e_1_3_10_19_2","volume-title":"Core Patient-Reported Outcomes in Cancer Clinical Trials Guidance for Industry","year":"2021","unstructured":"Core Patient-Reported Outcomes in Cancer Clinical Trials Guidance for Industry, in U.S. Department of Health and Human Services FaDA, 2021"},{"key":"e_1_3_10_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2021.06.012"},{"key":"e_1_3_10_21_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2021.741334"},{"key":"e_1_3_10_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.30580"},{"key":"e_1_3_10_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206125"},{"key":"e_1_3_10_24_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-07-2541"},{"key":"e_1_3_10_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-6337-2"},{"key":"e_1_3_10_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds243"},{"key":"e_1_3_10_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-010-9673-x"},{"key":"e_1_3_10_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-021-03059-3"},{"key":"e_1_3_10_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00038-005-4094-2"},{"key":"e_1_3_10_30_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph192215408"},{"key":"e_1_3_10_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djac166"},{"key":"e_1_3_10_32_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-11-26"},{"key":"e_1_3_10_33_2","unstructured":"Reference deleted"},{"key":"e_1_3_10_34_2","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2013.0035"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.24.00038","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T21:59:31Z","timestamp":1727387971000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.24.00038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":33,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1200\/JCO.24.00038"],"URL":"https:\/\/doi.org\/10.1200\/jco.24.00038","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"2024-01-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-18","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}