{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T03:42:04Z","timestamp":1782272524856,"version":"3.54.5"},"reference-count":56,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"36","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2024,12,20]]},"abstract":"<jats:sec>\n            <jats:title>PURPOSE<\/jats:title>\n            <jats:p>Caregivers of patients with primary malignant brain tumors (PMBT) experience significant psychological distress. We assessed the effect of a psychological intervention (NeuroCARE) on anxiety symptoms among PMBT caregivers.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS<\/jats:title>\n            <jats:p>We conducted a randomized trial of NeuroCARE versus usual care in PMBT caregivers with elevated anxiety (Generalized Anxiety Disorder-7 score \u22655) within 6 months of the patient's diagnosis. NeuroCARE was developed for PMBT caregivers and consists of six telehealth sessions with a behavioral health specialist. Participants completed surveys at baseline, 11-week (postintervention), and 16-week (1-month postintervention) time points. The primary outcome was 11-week anxiety symptoms (Hospital Anxiety and Depression Scale [HADS]-Anxiety Subscale). We also measured depression symptoms (HADS-Depression Subscale), quality of life (QOL; Caregiver QOL survey), caregiver burden (Caregiver Reaction Assessment), self-efficacy (Lewis Cancer Self-Efficacy Scale), coping (Measure of Current Status), and post-traumatic stress disorder (PTSD) symptoms (PTSD Checklist for DSM-5). We conducted analysis of covariance and linear mixed-effects regression analyses to examine intervention effects on study outcomes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>\n              We enrolled 120 caregivers (60\/group) between October 2019 and June 2022; 105 were evaluable for the primary outcome. At 11 weeks, NeuroCARE participants reported significantly lower anxiety symptoms than usual care participants (\n              <jats:italic>M<\/jats:italic>\n              , 8.87\n              <jats:italic>v<\/jats:italic>\n              10.69;\n              <jats:italic>P<\/jats:italic>\n              = .008). NeuroCARE caregivers also reported significantly lower depression symptoms (\n              <jats:italic>M<\/jats:italic>\n              , 6.08\n              <jats:italic>v<\/jats:italic>\n              7.77;\n              <jats:italic>P<\/jats:italic>\n              = .004), and better self-efficacy (\n              <jats:italic>M<\/jats:italic>\n              , 128.81\n              <jats:italic>v<\/jats:italic>\n              111.17;\n              <jats:italic>P<\/jats:italic>\n              &lt; .001) and coping (\n              <jats:italic>M<\/jats:italic>\n              , 32.25\n              <jats:italic>v<\/jats:italic>\n              25.65;\n              <jats:italic>P<\/jats:italic>\n              &lt; .001) at 11 weeks. Study groups did not differ significantly in 11-week QOL, caregiver burden, or PTSD symptoms. In longitudinal analyses, intervention effects on depression symptoms, self-efficacy, and coping were sustained.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION<\/jats:title>\n            <jats:p>A novel, population-specific psychological intervention led to improved anxiety and depression symptoms, self-efficacy, and coping among PMBT caregivers.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1200\/jco.24.00065","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T19:59:16Z","timestamp":1726516756000},"page":"4252-4262","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":13,"title":["NeuroCARE: A Randomized Controlled Trial of a Psychological Intervention for Caregivers of Patients With Primary Malignant Brain Tumors"],"prefix":"10.1200","volume":"42","clinical-trial-number":[{"clinical-trial-number":"nct04109209","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8428-0841","authenticated-orcid":true,"given":"Deborah A.","family":"Forst","sequence":"first","affiliation":[{"name":"Massachusetts General Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyx F.","family":"Podgurski","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1067-3164","authenticated-orcid":true,"given":"Sumita M.","family":"Strander","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8791-6506","authenticated-orcid":true,"given":"Jessica D.","family":"Whitman","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibani","family":"Datta","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kedie","family":"Pintro","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4355-5853","authenticated-orcid":true,"given":"Nora K.","family":"Horick","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3974-634X","authenticated-orcid":true,"given":"Kelcie D.","family":"Willis","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4479-0350","authenticated-orcid":true,"given":"Timothy S.","family":"Sannes","sequence":"additional","affiliation":[{"name":"University of Massachusetts Memorial Medical Center, Worcester, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0979-4076","authenticated-orcid":true,"given":"Joseph A.","family":"Greer","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3556-1495","authenticated-orcid":true,"given":"Areej","family":"El-Jawahri","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9740-624X","authenticated-orcid":true,"given":"Jamie M.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7268-5921","authenticated-orcid":true,"given":"Jennifer S.","family":"Temel","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_10_2_2","first-page":"103","article-title":"Mapping the nature of distress raised by patients with high-grade glioma and their family caregivers: A descriptive longitudinal study","volume":"7","author":"Philip J","year":"2020","unstructured":"Philip J, Collins A, Panozzo S, et al: Mapping the nature of distress raised by patients with high-grade glioma and their family caregivers: A descriptive longitudinal study. 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