{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T15:41:40Z","timestamp":1765294900751},"reference-count":19,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"4","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JGO"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> Cervical cancer is a leading cause of cancer-related mortality in low- and middle-income countries (LMICs) and screening in LMICs is extremely limited. We aimed to implement on-site high-risk human papillomavirus (hrHPV) DNA testing in cohorts of women from an urban factory and from a rural village. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> A total of 802 women were recruited for this study in partnership with La Liga Contra el Cancer through the establishment of women\u2019s health resource fairs at two locations in Honduras: a textile factory (n = 401) in the city of San Pedro Sula and the rural village of El Rosario (n = 401) in Yoro. Participants received a routine cervical examination during which three sterile cytobrushes were used to collect cervical samples for testing. hrHPV genotyping was performed using a hrHPV genotyping assay and a real-time polymerase chain reaction instrument. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> hrHPV status across all participants at both sites was 13% hrHPV positive and 67% hrHPV negative. When hrHPV status was compared across all three testing sites, hrHPV-positive rates were approximately equal among the factory (13%), village (12%), and confirmatory testing at Dartmouth-Hitchcock Medical Center (Lebanon, NH; 14%). hrHPV genotype was compared across sites, with HPV16 showing the highest infection rate (15%), followed by HPV59 (12%), and HPV68 (11%). There was a low prevalence of HPV18 observed in both populations compared with the hrHPV-positive population in the United States. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> In collaboration with oncologists and pathologists from La Liga Contra el Cancer, we were able to provide a continuum of care once health-fair testing was performed. We established a method and implementation plan for hrHPV testing that is sustainable in LMICs. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jgo.17.00035","type":"journal-article","created":{"date-parts":[[2017,8,28]],"date-time":"2017-08-28T19:59:23Z","timestamp":1503950363000},"page":"1-8","update-policy":"http:\/\/dx.doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":4,"title":["Implementation of Multicolor Melt Curve Analysis for High-Risk Human Papilloma Virus Detection in Low- and Middle-Income Countries: A Pilot Study for Expanded Cervical Cancer Screening in Honduras"],"prefix":"10.1200","author":[{"given":"Scott A.","family":"Turner","sequence":"first","affiliation":[{"name":"Scott A. Turner, Sophie J. Deharvengt, Kathleen Doyle Lyons, Linda Kennedy, and Gregory J. Tsongalis, Dartmouth-Hitchcock Medical Center, Lebanon; Ethan P.M. LaRochelle, Dartmouth College, Hanover, NH; Jorge Arturo Plata Espinal and Suyapa Bejarano, La Liga Contra el Cancer, San Pedro Sula, Honduras."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie J.","family":"Deharvengt","sequence":"additional","affiliation":[{"name":"Scott A. Turner, Sophie J. Deharvengt, Kathleen Doyle Lyons, Linda Kennedy, and Gregory J. Tsongalis, Dartmouth-Hitchcock Medical Center, Lebanon; Ethan P.M. LaRochelle, Dartmouth College, Hanover, NH; Jorge Arturo Plata Espinal and Suyapa Bejarano, La Liga Contra el Cancer, San Pedro Sula, Honduras."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen Doyle","family":"Lyons","sequence":"additional","affiliation":[{"name":"Scott A. Turner, Sophie J. Deharvengt, Kathleen Doyle Lyons, Linda Kennedy, and Gregory J. Tsongalis, Dartmouth-Hitchcock Medical Center, Lebanon; Ethan P.M. 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