{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:27:21Z","timestamp":1777505241119,"version":"3.51.4"},"reference-count":20,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"5","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JGO"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec><jats:title>PURPOSE<\/jats:title><jats:p> Limited information is available on multiple myeloma (MM), chronic lymphocytic leukemia (CLL), and non-Hodgkin lymphoma (NHL) management in Latin America. The primary objective of the Hemato-Oncology Latin America (HOLA) study was to describe patient characteristics and treatment patterns of Latin American patients with MM, CLL, and NHL. <\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p> This study was a multicenter, retrospective, medical chart review of patients with MM, CLL, and NHL in Latin America identified between January 1, 2006, and December 31, 2015. Included were adults with at least 1 year of follow-up (except in cases of death within 1 year of diagnosis) treated at 30 oncology hospitals (Argentina, 5; Brazil, 9; Chile, 1; Colombia, 5; Mexico, 6; Panama\/Guatemala, 4). <\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p> Of 5,140 patients, 2,967 (57.7%) had NHL, 1,518 (29.5%) MM, and 655 (12.7%) CLL. Median follow-up was 2.2 years for MM, 3.0 years for CLL, and 2.2 years for NHL, and approximately 26% died during the study observation period. Most patients had at least one comorbidity at diagnosis. The most frequent induction regimen was thalidomide-based chemotherapy for MM and chlorambucil with or without prednisone for CLL. Most patients with NHL had diffuse large B-cell lymphoma (DLBCL; 49.1%) or follicular lymphoma (FL; 19.5%). The majority of patients with DLBCL or FL received rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone. <\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p> The HOLA study generated an unprecedented level of high-quality, real-world evidence on characteristics and treatment patterns of patients with hematologic malignancies. Regional disparities in patient characteristics may reflect differences in ethnoracial identity and level of access to care. These data provide needed real-world evidence to understand the disease landscape in Latin America and may be used to inform clinical and health policy decision making. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jgo.19.00025","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T22:20:20Z","timestamp":1574893220000},"page":"1-19","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":36,"title":["Epidemiology of Hematologic Malignancies in Real-World Settings: Findings From the Hemato-Oncology Latin America Observational Registry Study"],"prefix":"10.1200","author":[{"given":"Vania","family":"Tietsche de Moraes Hungria","sequence":"first","affiliation":[{"name":"Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Chiattone","sequence":"additional","affiliation":[{"name":"Faculdade de Ciencias M\u00e9dicas\u2013Santa Casa de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Pavlovsky","sequence":"additional","affiliation":[{"name":"FUNDALEU, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina M.","family":"Abenoza","sequence":"additional","affiliation":[{"name":"Fundacion Santa Fe de Bogot\u00e1, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gladys P.","family":"Agreda","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Armenta","sequence":"additional","affiliation":[{"name":"ISSEMYM, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celso","family":"Arrais","sequence":"additional","affiliation":[{"name":"Hospital S\u00ecrio-Liban\u00eas, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Avenda\u00f1o Flores","sequence":"additional","affiliation":[{"name":"Medical Solution SA, Guatemala City, Guatemala"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Barroso","sequence":"additional","affiliation":[{"name":"Hospital Universitario Walter Cantidio, Fortaleza, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana L.","family":"Basquiera","sequence":"additional","affiliation":[{"name":"Hospital Privado Centro M\u00e9dico de C\u00f3rdoba, C\u00f3rdoba, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Cao","sequence":"additional","affiliation":[{"name":"Instituto Nacional del Cancer, Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria S.","family":"Cugliari","sequence":"additional","affiliation":[{"name":"Instituto de Oncolog\u00eda \u00c1ngel H. 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