{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T20:37:32Z","timestamp":1764103052502},"reference-count":25,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"5","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JGO"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec><jats:title>PURPOSE<\/jats:title><jats:p> There is limited knowledge of the long-term health effects of the Chernobyl nuclear power plant accident that occurred more than 30 years ago in Ukraine. This study describes trends in the incidence of solid organ malignancy in Ukraine and the five regions most affected by the radioactive fallout. <\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p> The National Cancer Registry of Ukraine was queried for age-standardized incidence rates (ASIRs) of solid organ malignancy in Ukraine and the regions of Kyiv, Chernihiv, Zhytomyr, Rivne, and Volyn covering the period of 1999 to 2016. Joinpoint analysis was used to calculate the average annual percentage of change. <\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p> The highest burdens of cancer incidence in Ukraine were seen in the lung, stomach, breast, and prostate. We observed significant increases in the ASIRs of colon (average annual percentage of change, 1.5 [95% CI, 1.3 to 1.7]), rectal (0.9 [95% CI, 0.6 to 1.2]), kidney (2.3 [95% CI, 1.8 to 2.9]), thyroid (4.2 [95% CI, 3.1 to 5.3]), breast (1 [95% CI, 0.6 to 1.4]), cervical (0.7 [95% CI, 0.3 to 1.2]), and prostate (3.9 [95% CI, 3.6 to 4.2]) cancers, with decreases in stomach (\u22122.4 [95% CI, \u22122.5 to \u22122.3]) and lung (\u22121.8 [95% CI, \u22122.1 to \u22121.5]) cancers. ASIRs in the affected regions were similar to nationwide rates, with the exception of those for Kyiv. <\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p> The incidence rates of many solid organ malignancies in Ukraine are rising. However, the rates of solid organ malignancy in the five regions most affected by fallout did not substantially differ from national patterns, with the exception of those for Kyiv. Ongoing monitoring of cancer incidence in Ukraine is necessary to understand how best to decrease disease burden nationwide and to elucidate the causes of regional variations in ASIRs, such as access to diagnostics and environmental exposures. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jgo.19.00099","type":"journal-article","created":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T19:56:19Z","timestamp":1566935779000},"page":"1-10","update-policy":"http:\/\/dx.doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":7,"title":["Trends in Solid Tumor Incidence in Ukraine 30 Years After Chernobyl"],"prefix":"10.1200","author":[{"given":"Krystle M.","family":"Leung","sequence":"first","affiliation":[{"name":"Brigham and Women\u2019s Hospital, Boston, MA"},{"name":"Harvard Medical School, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galyna","family":"Shabat","sequence":"additional","affiliation":[{"name":"National Cancer Institute, Kyiv, Ukraine"},{"name":"University of Turin, Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Lu","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital, Boston, MA"},{"name":"Harvard Medical School, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam C.","family":"Fields","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey","family":"Lukashenko","sequence":"additional","affiliation":[{"name":"National Cancer Institute, Kyiv, Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer S.","family":"Davids","sequence":"additional","affiliation":[{"name":"University of Massachusetts Medical School, Worcester, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelya","family":"Melnitchouk","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital, Boston, MA"},{"name":"Harvard Medical School, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","reference":[{"key":"B1","volume-title":"Health Effects of the Chernobyl Accident and Special Health Care Programmes: Report of the UN Chernobyl Forum Expert Group \u201cHealth\u201d","author":"Bennett B","year":"2006"},{"key":"B2","volume-title":"UNSCEAR 2008 Report Vol. II: Sources and Effects of Ionizing Radiation","author":"United Nations Scientific Committee on the Effects of Atomic Radiation","year":"2011"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1667\/RR3479.1"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyg205"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.2203\/dose-response.13-039.Jargin"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/00004032-199803000-00003"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2015.02.002"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-006-0001-5"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2011.01.510"},{"key":"B12","volume-title":"ENCR Scientific Meeting and General Assembly","author":"Ryzhov A","year":"2016"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2018.02.002"},{"key":"B14","first-page":"1","volume":"4","author":"Melnitchouk N","year":"2018","journal-title":"J Glob Oncol"},{"key":"B16","volume-title":"Cancer Incidence in Five Continents","author":"Bray F","year":"2017"},{"key":"B17","volume-title":"Cancer Incidence in Five Continents, CI5plus: IARC CancerBase No. 9","author":"Ferlay J","year":"2018"},{"key":"B18","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0095-4543(21)00940-4","volume":"19","author":"Dewar MA","year":"1992","journal-title":"Prim Care"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3466-y"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/30.1.181"},{"key":"B21","volume-title":"An Avoidable Tragedy: Combating Ukraine\u2019s Health Crisis. 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