{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T17:01:10Z","timestamp":1751734870495},"reference-count":32,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"6","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Global Oncology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>PURPOSE<\/jats:title><jats:p> Adult T-cell lymphoma\/leukemia (ATL) is a rare and aggressive peripheral T-cell malignancy caused by human T-cell lymphotropic virus-1 infection, which occurs in areas of high prevalence, predominantly in Japan and the Caribbean basin. Most ATL literature is derived from Japan and little is published about Caribbean patients. We describe the clinicopathologic characteristics and treatment outcomes of our Caribbean patients who have ATL at the State University of New York Downstate Medical Center and Kings County Hospital. <\/jats:p><\/jats:sec><jats:sec><jats:title>PATIENTS AND METHODS<\/jats:title><jats:p> We conducted a retrospective analysis of our patients with ATL who were diagnosed between 2005 and 2017. Medical records were reviewed for clinicopathologic data and treatment outcomes. The final analysis included acute and lymphomatous subtypes only. For the univariable analysis, outcomes were calculated by using a log-rank test, and survival curves were estimated by the Kaplan-Meier method. <\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p> We identified 63 patients with acute (55%) and lymphomatous (45%) subtypes, 95% of whom had Ann Arbor stage III to IV disease. The median age was 54 years, and the study population was predominantly female (65%). Most patients (82%) received first-line etoposide, cyclophosphamide, vincristine, doxorubicin, and prednisone (EPOCH) or cyclophosphamide, vincristine, doxorubicin, and prednisone (CHOP) chemotherapy (10%) with an overall response rate of 46%. The median overall survival was 5.5 months, and the median progression-free survival was 4 months. Incidence of atypical immunophenotype (32%) was higher than previously reported in the Japanese literature and was associated with worse survival ( P = .04). Abnormal cytogenetics correlated with shorter progression-free survival ( P &lt; .05). <\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p> We describe here the clinicopathologic characteristics and treatment outcomes of our Caribbean patients with aggressive ATL, which is largely chemotherapy resistant, and the challenges of treating a population with unmet medical needs. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jgo.19.00208","type":"journal-article","created":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T20:04:00Z","timestamp":1585944240000},"page":"548-556","update-policy":"http:\/\/dx.doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Characteristics and Outcomes of Caribbean Patients With Adult T-Cell Lymphoma\/Leukemia at Two Affiliated New York City Hospitals"],"prefix":"10.1200","author":[{"given":"Edwin","family":"Chiu","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Hematology and Medical Oncology, State University of New York (SUNY) Downstate Medical Center, Brooklyn, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bachar","family":"Samra","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology and Medical Oncology, State University of New York (SUNY) Downstate Medical Center, Brooklyn, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Tam","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology and Medical Oncology, State University of New York (SUNY) Downstate Medical Center, Brooklyn, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babak","family":"Baseri","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology and Medical Oncology, State University of New York (SUNY) Downstate Medical Center, Brooklyn, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pathology, SUNY Downstate Medical Center, Brooklyn, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Luhrs","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology and Medical Oncology, State University of New York (SUNY) Downstate Medical Center, Brooklyn, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Gonsky","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology and Medical Oncology, State University of New York (SUNY) Downstate Medical Center, Brooklyn, NY"},{"name":"Department of Medicine, Division of Hematology and Medical Oncology, New York City Health and Hospitals\/Kings County, Brooklyn, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Sawas","sequence":"additional","affiliation":[{"name":"Center for Lymphoid Malignancies, Columbia University Medical Center, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyn","family":"Taiwo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology and Medical Oncology, State University of New York (SUNY) Downstate Medical Center, Brooklyn, NY"},{"name":"Department of Medicine, Division of Hematology and Medical Oncology, New York City Health and Hospitals\/Kings County, Brooklyn, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gurinder","family":"Sidhu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology and Medical Oncology, State University of New York (SUNY) Downstate Medical Center, Brooklyn, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","reference":[{"key":"B1","unstructured":"Ohsima   K  ,  \n\t\t\t\t\t\t\tJaffe   ES  ,  \n\t\t\t\t\t\t\tYoshino   T  ,  et al  :  Adult T-cell leukaemia\/lymphoma, In Swerdlow SH, Campo E, Harris NL, et al (eds): WHO Classification of Tumours of Haematopoetic and Lymphoid Tissues, World Health Organization Classification of Tumours (ed 4). 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