{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T02:21:46Z","timestamp":1770776506764,"version":"3.50.0"},"reference-count":34,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"6","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Global Oncology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>PURPOSE<\/jats:title><jats:p> Despite being the most common pediatric solid tumors, incidence and outcome of CNS tumors in Chinese children have not been systematically reported. We addressed this knowledge gap by comparing the epidemiology of pediatric CNS tumors in Hong Kong and the United States. <\/jats:p><\/jats:sec><jats:sec><jats:title>PATIENTS AND METHODS<\/jats:title><jats:p> Data between 1999 and 2016 from a population-based cancer registry in Hong Kong, China, on patients &lt; 18 years old with CNS tumors (Hong Kong cohort) and from the US SEER Program (Asian\/Pacific Islander and all ethnicities) were compared. Incidence and overall survival (OS) by histology were evaluated. <\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p> During the study period, 526 children were newly diagnosed with CNS tumors in Hong Kong (crude incidence rate, 2.47 per 100,000; 95% CI, 2.26 to 2.69). Adjusted incidences were significantly lower in the Hong Kong (2.51; 95% CI, 2.30 to 2.74) than in the SEER (Asian\/Pacific Islander: 3.26; 95% CI, 2.97 to 3.57; P &lt; .001; all ethnicities: 4.10 per 100,000; 95% CI, 3.99 to 4.22; P &lt; .001) cohorts. Incidences of germ cell tumors (0.57 v 0.24; P &lt; .001) were significantly higher, but those of glial and neuronal tumors (0.94 v 2.61; P &lt; .001), ependymomas (0.18 v 0.31; P = .005), and choroid plexus tumors (0.08 v 0.16; P = .045) were significantly lower in Hong Kong compared with SEER (all ethnicities) cohorts. Compared with the SEER (Asian\/Pacific Islander) cohort, histology-specific incidences were similar except for a lower incidence of glial and neuronal tumors in Hong Kong (0.94 v 1.74; P &lt; .001). Among cohorts, OS differed only for patients with glial and neuronal tumors (5-year OS: Hong Kong, 52.5%; SEER [Asian\/Pacific Islander], 73.6%; SEER [all ethnicities], 79.9%; P &lt; .001). <\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p> We identified important ethnic differences in the epidemiology of CNS tumors in Chinese children. These results will inform the development of pediatric neuro-oncology services in China and aid further etiologic studies. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jgo.19.00378","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T20:06:48Z","timestamp":1589227608000},"page":"704-721","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":19,"title":["Incidence and Outcomes of CNS Tumors in Chinese Children: Comparative Analysis With the Surveillance, Epidemiology, and End Results Program"],"prefix":"10.1200","author":[{"given":"Anthony P. Y.","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Oncology, St Jude Children\u2019s Research Hospital, Memphis, TN"},{"name":"Department of Pediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew M. K.","family":"Shing","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Hong Kong Children\u2019s Hospital, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis T. L.","family":"Ku","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Hong Kong Children\u2019s Hospital, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Hong Kong Children\u2019s Hospital, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung-Wing","family":"Luk","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Hong Kong Children\u2019s Hospital, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siu-Cheung","family":"Ling","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Princess Margaret Hospital, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin K. F.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, Queen Mary Hospital, Hong Kong SAR, China"},{"name":"Division of Neurosurgery, Department of Surgery, Hong Kong Children\u2019s Hospital, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dora L. W.","family":"Kwong","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilson W. S.","family":"Ho","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, Queen Mary Hospital, Hong Kong SAR, China"},{"name":"Division of Neurosurgery, Department of Surgery, Hong Kong Children\u2019s Hospital, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho-Keung","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Anatomical and Cellular Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amar","family":"Gajjar","sequence":"additional","affiliation":[{"name":"Department of Oncology, St Jude Children\u2019s Research Hospital, Memphis, TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Yasui","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Control, St Jude Children\u2019s Research Hospital, Memphis, TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Godfrey C. F.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China"},{"name":"Department of Pediatrics and Adolescent Medicine, Hong Kong Children\u2019s Hospital, Hong Kong SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory T.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Control, St Jude Children\u2019s Research Hospital, Memphis, TN"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30761-7"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.27.0421"},{"key":"B3","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S1470-2045(19)30339-0","volume":"20","author":"Force LM","year":"2019","journal-title":"Lancet Oncol"},{"key":"B4","doi-asserted-by":"crossref","first-page":"iv1","DOI":"10.1093\/neuonc\/noy131","volume":"20","author":"Ostrom QT","year":"2018","journal-title":"Neuro-oncol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001656"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a011577"},{"key":"B7","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1093\/neuonc\/noz123","volume":"21","author":"Ostrom QT","year":"2019","journal-title":"Neuro-oncol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.60.6376"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2541"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22127"},{"key":"B11","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1136\/archdischild-2018-316181","volume":"104","author":"Cai J","year":"2019","journal-title":"Arch Dis Child"},{"key":"B12","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/pbc.24043","volume":"59","author":"Bao PP","year":"2012","journal-title":"Pediatr Blood Cancer"},{"key":"B13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/pbc.21939","volume":"53","author":"Bao PP","year":"2009","journal-title":"Pediatr Blood Cancer"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70029-4"},{"key":"B15","first-page":"285","volume":"26","author":"Yang L","year":"2014","journal-title":"Chin J Cancer Res"},{"key":"B16","unstructured":"The Government of the Hong Kong Special Administrative Region Census and Statistics Department:   2011 Population Census .   https:\/\/www.censtatd.gov.hk\/hkstat\/sub\/so170.jsp"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-007-0243-4"},{"key":"B19","unstructured":"WHO  :  International Classification of Diseases for Oncology (ICD-O): Third Edition, First Revision .  Geneva, Switzerland, WHO ,  2013"},{"key":"B22","volume-title":"SEER Cancer Statistics Review, 1975-2016, National Cancer Institute","author":"Howlader N","year":"2019"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1545-1"},{"key":"B24","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1634\/theoncologist.2000-0312","volume":"5","author":"Packer RJ","year":"2000","journal-title":"Oncologist"},{"key":"B25","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3171\/jns.1969.30.2.0146","volume":"30","author":"Araki C","year":"1969","journal-title":"J Neurosurg"},{"key":"B26","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/s00381-010-1126-x","volume":"26","author":"Makino K","year":"2010","journal-title":"Childs Nerv Syst"},{"key":"B27","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1002\/cncr.21430","volume":"104","author":"Wong T-T","year":"2005","journal-title":"Cancer"},{"key":"B28","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s00381-001-0547-y","volume":"18","author":"Cho K-T","year":"2002","journal-title":"Childs Nerv Syst"},{"key":"B29","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nature13296","volume":"511","author":"Wang L","year":"2014","journal-title":"Nature"},{"key":"B30","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1158\/1055-9965.EPI-14-0207","volume":"23","author":"Johnson KJ","year":"2014","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/not151"},{"key":"B32","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1016\/j.ejca.2006.05.009","volume":"42","author":"Peris-Bonet R","year":"2006","journal-title":"Eur J Cancer"},{"key":"B33","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/pbc.22585","volume":"56","author":"Schmidt LS","year":"2011","journal-title":"Pediatr Blood Cancer"},{"key":"B34","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/sj.bjc.6603278","volume":"95","author":"Raaschou-Nielsen O","year":"2006","journal-title":"Br J Cancer"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1215\/15228517-2008-097"},{"key":"B36","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1001\/jamaoncol.2018.1789","volume":"4","author":"Ostrom QT","year":"2018","journal-title":"JAMA Oncol"},{"key":"B37","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1093\/neuonc\/nox091","volume":"19","author":"Leece R","year":"2017","journal-title":"Neuro-oncol"}],"container-title":["JCO Global Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JGO.19.00378","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T07:31:31Z","timestamp":1653809491000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JGO.19.00378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1200\/JGO.19.00378"],"URL":"https:\/\/doi.org\/10.1200\/jgo.19.00378","relation":{},"ISSN":["2687-8941"],"issn-type":[{"value":"2687-8941","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"2020-02-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}