{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T06:09:05Z","timestamp":1759385345649},"reference-count":9,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"12","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JOP"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p> Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm resulting from the fusion of the BCR-ABL genes, forming the Philadelphia chromosome. The diagnosis is often suspected when there is leukocytosis with left shift and basophilia. Confirmation of the diagnosis requires a demonstration of BCR-ABL by polymerase chain reaction. Using data from the William Beaumont laboratory data registry, we conducted a retrospective review of all the orders for BCR-ABL tests sent to the clinical pathology laboratory between March 11, 2014 and September 12, 2014. We concluded that the presence of concurrent neutrophilia and basophilia has a sensitivity of 100% (95% CI, 69.15% to 100%) and specificity of 100% (95% CI, 93.15% to 100%) in the initial diagnosis of CML. Our results suggest that the presence of both neutrophilia and basophilia should be used as a threshold for the placement of orders for BCR-ABL in the initial diagnosis of CML in patients with leukocytosis with left shift and provide a basis for a reduction in health care spending. Restricting BCR-ABL tests to this population would save approximately $198 million annually in national health care spending. <\/jats:p>","DOI":"10.1200\/jop.2016.014449","type":"journal-article","created":{"date-parts":[[2016,9,14]],"date-time":"2016-09-14T02:39:23Z","timestamp":1473820763000},"page":"e1001-e1005","update-policy":"http:\/\/dx.doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":10,"title":["<i>BCR-ABL<\/i> Testing by Polymerase Chain Reaction in Patients With Neutrophilia: The William Beaumont Hospital Experience and the Case for Rational Laboratory Test Requests"],"prefix":"10.1200","volume":"12","author":[{"given":"Foluso","family":"Ogunleye","sequence":"first","affiliation":[{"name":"William Beaumont Hospital, Oakland University William Beaumont School of Medicine, Royal Oak, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"William Beaumont Hospital, Oakland University William Beaumont School of Medicine, Royal Oak, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Allen","sequence":"additional","affiliation":[{"name":"William Beaumont Hospital, Oakland University William Beaumont School of Medicine, Royal Oak, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Brennan","sequence":"additional","affiliation":[{"name":"William Beaumont Hospital, Oakland University William Beaumont School of Medicine, Royal Oak, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Huang","sequence":"additional","affiliation":[{"name":"William Beaumont Hospital, Oakland University William Beaumont School of Medicine, Royal Oak, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhou","family":"Yu","sequence":"additional","affiliation":[{"name":"William Beaumont Hospital, Oakland University William Beaumont School of Medicine, Royal Oak, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Huben","sequence":"additional","affiliation":[{"name":"William Beaumont Hospital, Oakland University William Beaumont School of Medicine, Royal Oak, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ishmael","family":"Jaiyesimi","sequence":"additional","affiliation":[{"name":"William Beaumont Hospital, Oakland University William Beaumont School of Medicine, Royal Oak, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2015.08.010"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/315550a0"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1126\/science.2408149"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-209262"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199907153410306"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199907153410306"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.d01-1982.x"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20257"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-11-467787"}],"container-title":["Journal of Oncology Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JOP.2016.014449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T10:48:44Z","timestamp":1653821324000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JOP.2016.014449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":9,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1200\/JOP.2016.014449"],"URL":"https:\/\/doi.org\/10.1200\/jop.2016.014449","relation":{},"ISSN":["1554-7477","1935-469X"],"issn-type":[{"value":"1554-7477","type":"print"},{"value":"1935-469X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"2016-09-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}