{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:15:58Z","timestamp":1770743758406,"version":"3.49.0"},"reference-count":35,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO Oncology Advances"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n            <jats:title>PURPOSE<\/jats:title>\n            <jats:p>NRG-RTOG 1203 reported that intensity-modulated radiation therapy (IMRT) reduced patient-reported GI toxicities in patients with cervical\/endometrial cancer receiving postoperative RT, compared with 3-dimensional conformal radiation therapy (3DRT). We conducted a secondary analysis of patient-reported sexual function (PR-SF) among treatment groups to identify factors associated with sexual dysfunction.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS AND MATERIALS<\/jats:title>\n            <jats:p>Patients on NRG-RTOG 1203 were randomly assigned to 3DRT versus IMRT and completed Patient-Reported Outcomes (PRO)-Common Terminology Criteria for Adverse Events (CTCAE) and FACT-Cx surveys at baseline, week 5 of RT, and at 4-6 weeks, 1 year, and 3 years after RT. Patient responses to FACT-Cx sexual function questions were analyzed. The between-arm frequency and severity of responses and their comparison with PRO-CTCAE GI toxicity were tested using chi-square tests. A repeated-measures logistic regression model was used to determine the impact of clinical and treatment factors on PR-SF.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>\n              Two hundred thirty-six patients completed PR-SF questions; 125 (53%) received 3DRT and 111 (47%) IMRT. There were no significant differences in PR-SF between groups (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &gt; .05). After RT, responses to \u201cI am afraid to have sex\u201d and \u201cI am interested in sex\u201d significantly improved over time (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              = .007 and\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              = .03, respectively). At 1 year after RT, women with interference from abdominal pain were more bothered by odor from the vagina versus women with no interference of abdominal pain (5%\n              <jats:italic toggle=\"yes\">v<\/jats:italic>\n              0%,\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              = .006). Additionally, at 1 year after RT, women with no severity of abdominal pain or no interference from abdominal pain liked their body appearance more versus women with at least some abdominal pain or some interference from abdominal pain (34%\n              <jats:italic toggle=\"yes\">v<\/jats:italic>\n              13%,\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              = .003 and 32%\n              <jats:italic toggle=\"yes\">v<\/jats:italic>\n              6%,\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              = .001, respectively).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION<\/jats:title>\n            <jats:p>PR-SF was similar between treatment groups. After RT, fear of sex declined and interest in sex improved over time. Women with GI toxicity after RT completion are at risk for worse sexual function.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1200\/oa-24-00088","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T19:59:09Z","timestamp":1747079949000},"source":"Crossref","is-referenced-by-count":2,"title":["Patient-Reported Outcomes During Pelvic Radiation Therapy: A Secondary Analysis on Sexual Function From NRG-RTOG 1203"],"prefix":"10.1200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0314-6972","authenticated-orcid":true,"given":"Kelsey L.","family":"Corrigan","sequence":"first","affiliation":[{"name":"University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7312-1194","authenticated-orcid":true,"given":"Rebecca","family":"Paulus","sequence":"additional","affiliation":[{"name":"NRG Oncology Statistics and Data Management Center, Philadelphia, PA"},{"name":"American College of Radiology, Philadelphia, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2081-0735","authenticated-orcid":true,"given":"Ann H.","family":"Klopp","sequence":"additional","affiliation":[{"name":"University of Texas MD Anderson Cancer Center, Houston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3393-0349","authenticated-orcid":true,"given":"Lari B.","family":"Wenzel","sequence":"additional","affiliation":[{"name":"University of California-Irvine, Irvine, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5140-502X","authenticated-orcid":true,"given":"Anamaria R.","family":"Yeung","sequence":"additional","affiliation":[{"name":"University of Florida, Gainesville, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1045-1425","authenticated-orcid":true,"given":"J. 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