{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T16:01:52Z","timestamp":1775145712339,"version":"3.50.1"},"reference-count":38,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO Oncol Adv"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>More research is needed on the acceptability and effectiveness of cigarette smoking cessation treatments for patients with cancer. This pilot comparative effectiveness trial contrasted varenicline therapy combined with cancer-focused counseling versus standard smoking cessation treatment to assess the reach, acceptability, and preliminary effectiveness of targeted treatment offered proactively to adult patients with cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Electronic health records identified adult patients via quarterly reports (January-September, 2024) with cancer diagnoses who smoked tobacco in the past year (N = 574) for tobacco use treatment outreach. Eligible patients were enrolled from March to November, 2024, in an effectiveness trial comparing standard smoking cessation treatment (2 weeks of nicotine patch + 3 counseling calls) with enhanced treatment (12 weeks of varenicline + 7 cancer-targeted counseling calls). Follow-up outcome calls were conducted 12 and 26 weeks after a target quit date. Participants reporting no smoking at 26 weeks postquit were asked to provide a saliva or breath sample to confirm abstinence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Among patients eligible at the time of phone outreach (n = 406), 52 (12.8%) were enrolled in the trial. In both Standard Care (n = 26) and Enhanced Care (n = 26), at least 23 (88.5%) participants completed some counseling and received study medications. Satisfaction ratings were higher in Enhanced than Standard Care. At 12 weeks postquit, self-reported 7-day point-prevalence abstinence was reported by six (23.1%) Standard Care and nine (34.6%) Enhanced Care participants (odds ratio [OR], 1.76 [95% CI, 0.52 to 5.97]). At 26-weeks postquit, two (7.7%) Standard Care and seven (26.9%) Enhanced Care participants had biochemically confirmed abstinence (OR, 4.4 [95% CI, 0.82 to 23.8]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>This pilot study produced evidence supporting the reach, acceptability, and potential effect sizes of enhanced and cancer-focused smoking cessation counseling and medication treatment for adult patients with cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/oa-25-00169","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T19:59:08Z","timestamp":1774036748000},"source":"Crossref","is-referenced-by-count":0,"title":["Reach, Acceptability, and Effectiveness of Proactive Outreach and Varenicline With Cancer-Focused Counseling for Patients With Cancer: A Pilot Randomized Comparative Effectiveness Trial"],"prefix":"10.1200","volume":"3","clinical-trial-number":[{"clinical-trial-number":"nct06218823","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6350-4247","authenticated-orcid":true,"given":"Jesse T.","family":"Kaye","sequence":"first","affiliation":[{"name":"Center for Tobacco Research and Intervention, University of Wisconsin School of Medicine and Public Health, Madison, WI"},{"name":"Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas M.","family":"Piasecki","sequence":"additional","affiliation":[{"name":"Center for Tobacco Research and Intervention, University of Wisconsin School of Medicine and Public Health, Madison, WI"},{"name":"Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3460-1691","authenticated-orcid":true,"given":"Michael C.","family":"Fiore","sequence":"additional","affiliation":[{"name":"Center for Tobacco Research and Intervention, University of Wisconsin School of Medicine and Public Health, Madison, WI"},{"name":"Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6179-6386","authenticated-orcid":true,"given":"Timothy B.","family":"Baker","sequence":"additional","affiliation":[{"name":"Center for Tobacco Research and Intervention, University of Wisconsin School of Medicine and Public Health, Madison, WI"},{"name":"Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3842-897X","authenticated-orcid":true,"given":"Mark E.","family":"Zehner","sequence":"additional","affiliation":[{"name":"Center for Tobacco Research and Intervention, University of Wisconsin School of Medicine and Public Health, Madison, WI"},{"name":"Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2682-4596","authenticated-orcid":true,"given":"Brian S.","family":"Williams","sequence":"additional","affiliation":[{"name":"Center for Tobacco Research and Intervention, University of Wisconsin School of Medicine and Public Health, Madison, WI"},{"name":"Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI"},{"name":"Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4502-6936","authenticated-orcid":true,"given":"Wendy S.","family":"Slutske","sequence":"additional","affiliation":[{"name":"Center for Tobacco Research and Intervention, University of Wisconsin School of Medicine and Public Health, Madison, WI"},{"name":"Department of Family Medicine and Community Health, University of Wisconsin School of Medicine and Public Health, Madison, WI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle E.","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Center for Tobacco Research and Intervention, University of Wisconsin School of Medicine and Public Health, Madison, WI"},{"name":"Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","reference":[{"key":"e_1_3_12_2_2","volume-title":"Treating Smoking in Cancer Patients: An Essential Component of Cancer Care","author":"U.S. National Cancer Institute","year":"2022","unstructured":"U.S. National Cancer Institute: Treating Smoking in Cancer Patients: An Essential Component of Cancer Care. Bethesda, MD, U.S. Department of Health and Human Services, National Institutes of Health, National Cancer Institute, 2022"},{"key":"e_1_3_12_3_2","volume-title":"The Health Consequences of Smoking\u201450 Years of Progress: A Report of the Surgeon General","author":"U.S. Department of Health and Human Services","year":"2014","unstructured":"U.S. Department of Health and Human Services: The Health Consequences of Smoking\u201450 Years of Progress: A Report of the Surgeon General. Atlanta, GA, Centers for Disease Control and Prevention, 2014"},{"key":"e_1_3_12_4_2","volume-title":"A Report of the Surgeon General","author":"U.S. Department of Health and Human Services: Smoking Cessation","year":"2020","unstructured":"U.S. Department of Health and Human Services: Smoking Cessation: A Report of the Surgeon General. Atlanta, GA, Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2020"},{"key":"e_1_3_12_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.1703"},{"key":"e_1_3_12_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2024.4890"},{"key":"e_1_3_12_7_2","volume-title":"Smoking Cessation and Mortality Risk in Cancer Survivorship: Real-World Data From a National Cancer Institute\u2013Designated Cancer Center","author":"Tohmasi S","year":"2025","unstructured":"Tohmasi S, Baker TB, Heiden BT, et al: Smoking Cessation and Mortality Risk in Cancer Survivorship: Real-World Data From a National Cancer Institute\u2013Designated Cancer Center. 2025. https:\/\/jnccn.org\/view\/journals\/jnccn\/23\/10\/article-e257059.xml"},{"key":"e_1_3_12_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1813913"},{"key":"e_1_3_12_9_2","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1002\/cncr.34052","article-title":"Providing cessation treatment to every oncology patient who smokes: An essential component of cancer care","volume":"128","author":"Fiore MC","year":"2022","unstructured":"Fiore MC, Baker TB, Nolan MB, et al: Providing cessation treatment to every oncology patient who smokes: An essential component of cancer care. Cancer 128:1162-1164, 2022","journal-title":"Cancer"},{"key":"e_1_3_12_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.9072"},{"key":"e_1_3_12_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.12164"},{"key":"e_1_3_12_12_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0509"},{"key":"e_1_3_12_13_2","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr.2019.04.01"},{"key":"e_1_3_12_14_2","volume-title":"A Clinical Practice Guideline for Treating Tobacco Use and Dependence: 2008 Update. A U.S. Public Health Service Report","author":"Fiore MC","year":"2008","unstructured":"Fiore MC, Jaen CR, Baker TB, et al: A Clinical Practice Guideline for Treating Tobacco Use and Dependence: 2008 Update. A U.S. Public Health Service Report. Rockville, MD, U.S. Department of Health and Human Services, U.S. Public Health Service, 2008"},{"key":"e_1_3_12_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2020.03.016"},{"key":"e_1_3_12_16_2","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/pon.4978","article-title":"A randomized controlled trial of 24 weeks of varenicline for tobacco use among cancer patients: Efficacy, safety, and adherence","volume":"28","author":"Schnoll R","year":"2019","unstructured":"Schnoll R, Leone F, Veluz-Wilkins A, et al: A randomized controlled trial of 24 weeks of varenicline for tobacco use among cancer patients: Efficacy, safety, and adherence. Psychooncology 28:561-569, 2019","journal-title":"Psychooncology"},{"key":"e_1_3_12_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-010-9507-8"},{"key":"e_1_3_12_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-022-07553-x"},{"key":"e_1_3_12_19_2","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1089\/heq.2020.0157","article-title":"Achieving equity in the reach of smoking cessation services within the NCI Cancer Moonshot-Funded Cancer Center cessation initiative","volume":"5","author":"D\u2019Angelo H","year":"2021","unstructured":"D\u2019Angelo H, Webb Hooper M, Burris JL, et al: Achieving equity in the reach of smoking cessation services within the NCI Cancer Moonshot-Funded Cancer Center cessation initiative. Health Equity 5:424-430, 2021","journal-title":"Health Equity"},{"key":"e_1_3_12_20_2","doi-asserted-by":"publisher","DOI":"10.2217\/cer-2020-0004"},{"key":"e_1_3_12_21_2","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1136\/thoraxjnl-2015-207904","article-title":"Proactive tobacco treatment offering free nicotine replacement therapy and telephone counselling for socioeconomically disadvantaged smokers: A randomised clinical trial","volume":"71","author":"Fu SS","year":"2016","unstructured":"Fu SS, van Ryn M, Nelson D, et al: Proactive tobacco treatment offering free nicotine replacement therapy and telephone counselling for socioeconomically disadvantaged smokers: A randomised clinical trial. Thorax 71:446-453, 2016","journal-title":"Thorax"},{"key":"e_1_3_12_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2022.107101"},{"key":"e_1_3_12_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/tbm\/ibac009"},{"key":"e_1_3_12_24_2","unstructured":"EQUATOR Network: CONSORT 2025 Statement: Updated guideline for reporting randomised trials. (n.d.). https:\/\/www.equator-network.org\/reporting-guidelines\/consort\/"},{"key":"e_1_3_12_25_2","doi-asserted-by":"crossref","first-page":"e081123","DOI":"10.1136\/bmj-2024-081123","article-title":"CONSORT 2025 statement: Updated guideline for reporting randomised trials","volume":"389","author":"Hopewell S","year":"2025","unstructured":"Hopewell S, Chan A-W, Collins GS, et al: CONSORT 2025 statement: Updated guideline for reporting randomised trials. BMJ 389:e081123, 2025","journal-title":"BMJ"},{"key":"e_1_3_12_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2016.07.016"},{"key":"e_1_3_12_27_2","unstructured":"Kaye JT Fiore MC McCarthy DE et al: Comparative effectiveness trial of tobacco cessation treatments among cancer patients who smoke. 2026. https:\/\/doi.org\/10.17605\/OSF.IO\/EM4HC"},{"key":"e_1_3_12_28_2","unstructured":"Kaye JT Baker T Fiore MC et al: Comparative effectiveness trial of tobacco cessation treatments among cancer patients who smoke - registration. 2025. https:\/\/doi.org\/10.17605\/OSF.IO\/FV6NR"},{"key":"e_1_3_12_29_2","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2025","unstructured":"R Core Team: R: A Language and Environment for Statistical Computing. 2025. https:\/\/www.R-project.org\/"},{"key":"e_1_3_12_30_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17176089"},{"key":"e_1_3_12_31_2","first-page":"CD015226","article-title":"Pharmacological and electronic cigarette interventions for smoking cessation in adults: Component network meta-analyses","volume":"9","author":"Lindson N","year":"2023","unstructured":"Lindson N, Theodoulou A, Ord\u00f3\u00f1ez-Mena JM, et al: Pharmacological and electronic cigarette interventions for smoking cessation in adults: Component network meta-analyses. Cochrane Database Syst Rev 9:CD015226, 2023","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_12_32_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.12251"},{"key":"e_1_3_12_33_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.14581"},{"key":"e_1_3_12_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpo.2023.100463"},{"key":"e_1_3_12_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/pon.6171"},{"key":"e_1_3_12_36_2","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1001\/jama.2015.19284","article-title":"Effects of nicotine patch vs varenicline vs combination nicotine replacement therapy on smoking cessation at 26 weeks: A randomized clinical trial","volume":"315","author":"Baker TB","year":"2016","unstructured":"Baker TB, Piper ME, Stein JH, et al: Effects of nicotine patch vs varenicline vs combination nicotine replacement therapy on smoking cessation at 26 weeks: A randomized clinical trial. JAMA 315:371-379, 2016","journal-title":"JAMA"},{"key":"e_1_3_12_37_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.00936"},{"key":"e_1_3_12_38_2","doi-asserted-by":"crossref","first-page":"e114","DOI":"10.1017\/cts.2025.77","article-title":"Patient-generated health data: Impact on promoting patient-centered point of care tobacco treatment in patients with cancer","volume":"9","author":"Liu J","year":"2025","unstructured":"Liu J, Baker TB, Chen J, et al: Patient-generated health data: Impact on promoting patient-centered point of care tobacco treatment in patients with cancer. J Clin Transl Sci 9:e114, 2025","journal-title":"J Clin Transl Sci"},{"key":"e_1_3_12_39_2","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2021.7333"}],"container-title":["JCO Oncology Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/OA-25-00169","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T15:21:20Z","timestamp":1775143280000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/OA-25-00169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1200\/OA-25-00169"],"URL":"https:\/\/doi.org\/10.1200\/oa-25-00169","relation":{},"ISSN":["2994-9750"],"issn-type":[{"value":"2994-9750","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"article-number":"e2500169"}}