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GGT has become the standard of care for many cancers such as breast, ovarian, colorectal, pancreatic, and metastatic prostate cancer, and it is imperative that patients be offered timely and equitable access to testing as it can inform patient-physician shared decision making for management of the current cancer as well as anticipatory guidance for disease progression. Additionally, GGT guides screening for and prevention of secondary malignancies for the patient and cascade testing for at-risk family members. Here, we present data supporting the notion that clinicians should offer all patients with prostate cancer the opportunity to undergo comprehensive GGT for pathogenic germline variants known to be associated with familial cancer and\/or known to have implications for treatment and management.<\/jats:p>","DOI":"10.1200\/op-24-00626","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T20:59:50Z","timestamp":1734641990000},"page":"747-753","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":12,"title":["Implementation of Universal Germline Genetic Testing Into Standard of Care for Patients With Prostate Cancer: The Time Is Now"],"prefix":"10.1200","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5767-0548","authenticated-orcid":true,"given":"Neal","family":"Shore","sequence":"first","affiliation":[{"name":"Carolina Urologic Research Center, Myrtle Beach, SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5916-6393","authenticated-orcid":true,"given":"Sarah M.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Labcorp Genetics Inc (formerly Invitae Corp), San Francisco, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9205-3756","authenticated-orcid":true,"given":"Edward D.","family":"Esplin","sequence":"additional","affiliation":[{"name":"Labcorp Genetics Inc (formerly Invitae Corp), San Francisco, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0031-9655","authenticated-orcid":true,"given":"Emmanuel S.","family":"Antonarakis","sequence":"additional","affiliation":[{"name":"University of Minnesota, Masonic Cancer Center, Minneapolis, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8890-2951","authenticated-orcid":true,"given":"Pedro C.","family":"Barata","sequence":"additional","affiliation":[{"name":"Case Western Reserve University, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5600-9993","authenticated-orcid":true,"given":"Tomasz M.","family":"Beer","sequence":"additional","affiliation":[{"name":"The Knight Cancer Institute, Oregon Health &amp; Science University, Portland, OR"},{"name":"Exact Sciences Corporation, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3259-2226","authenticated-orcid":false,"given":"Himisha","family":"Beltran","sequence":"additional","affiliation":[{"name":"Dana Faber Cancer Institute, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0206-3895","authenticated-orcid":true,"given":"Alan","family":"Bryce","sequence":"additional","affiliation":[{"name":"City of Hope Cancer Center, Goodyear, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Cookson","sequence":"additional","affiliation":[{"name":"Stephenson Cancer Center, OU Health, The University of Oklahoma, Oklahoma City, OK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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