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Here, we highlight impedances to the diagnosis and coding of cachexia, including the absence of standardized therapy, a lack of incentives for accurate coding, and overlapping clinical features with other conditions. We differentiate cachexia from related conditions like unintentional weight loss, sarcopenia, frailty, and protein-calorie malnutrition, outlining their distinct clinical features and inter-relations. We propose an approach to enhance diagnostic accuracy and coding for cachexia. This effort will enable better prevalence data, translation of mechanism-based therapy development, patient identification and stratification, and ultimately advanced diagnostics and US Food and Drug Administration\u2013approved treatments for cachexia.<\/jats:p>","DOI":"10.1200\/op-24-00781","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T19:59:17Z","timestamp":1736798357000},"page":"926-931","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":9,"title":["Call to Improve Coding of Cancer-Associated Cachexia"],"prefix":"10.1200","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0784-9248","authenticated-orcid":false,"given":"Marcus D.","family":"Goncalves","sequence":"first","affiliation":[{"name":"NYU Langone Health, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6608-660X","authenticated-orcid":false,"given":"Richard F.","family":"Dunne","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center, Rochester, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy C.","family":"Moore","sequence":"additional","affiliation":[{"name":"Lungevity Foundation, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Phillips","sequence":"additional","affiliation":[{"name":"Morrison Healthcare, Atlanta, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1127-9425","authenticated-orcid":false,"given":"Steven B.","family":"Heymsfield","sequence":"additional","affiliation":[{"name":"Pennington Biomedical Research Center, Baton Rouge, LA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7540-4913","authenticated-orcid":false,"given":"Justin C.","family":"Brown","sequence":"additional","affiliation":[{"name":"Pennington Biomedical Research Center, Baton Rouge, LA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4587-0950","authenticated-orcid":false,"given":"Erin E.","family":"Talbert","sequence":"additional","affiliation":[{"name":"University of Iowa, Iowa City, IA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7820-3727","authenticated-orcid":false,"given":"Tobias","family":"Janowitz","sequence":"additional","affiliation":[{"name":"Cold Spring Harbor Laboratory, Cold Spring Harbor, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.03.028"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70218-7"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(05)80001-3"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.2017.025221"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13086"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02232-8"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12307"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197402)33:2<568::AID-CNCR2820330236>3.0.CO;2-2"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/SPC.0000000000000011"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.45.2722"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12167"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1200\/OP.23.00043"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2015.06.002"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.7573\/dic.212265"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2014.08.2661"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.00611"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/693458"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-020-03522-9"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-019-1115-1"},{"key":"e_1_3_6_21_2","first-page":"718","article-title":"Unintentional weight loss in older adults","volume":"89","author":"Gaddey HL","year":"2014","unstructured":"Gaddey HL, Holder K: Unintentional weight loss in older adults. 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