{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:48:04Z","timestamp":1792036084484,"version":"4.4.0"},"reference-count":35,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"1","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Oncol Pract"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>Immediate side effects after chimeric antigen receptor (CAR) T-cell therapy are well documented and include cytokine release syndrome (CRS) and immune effector-cell\u2013associated neurotoxicity (ICANS). However, long-term patient-reported outcomes are understudied. Using a social determinants of health (SDoH) framework, we described the long-term health-related quality of life (HRQoL), cognitive function, and symptom burden of patients in sustained remission after CAR T-cell therapy and examined the relationship between acute CRS and ICANS and long-term cognitive function and symptom burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This cross-sectional study included adults in remission after CAR T-cell therapy for multiple myeloma or B-cell lymphoma who were within 1-5 years post-treatment. We used bivariate analyses to measure associations between clinical and SDoH variables and long-term outcomes and linear regression to examine the relationship between ICANS and CRS toxicity and longer-term outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Participants (n = 58) were a median of 67 years of age (22-88), 72% had lymphoma, 28% had multiple myeloma, and they were a median of 2 years (1-4.7) post-CAR T-cell infusion. Most of the participants reported good HRQoL. Over one third of participants reported mild-to-moderate impairment in physical function, social roles and activities, or pain domains. Higher income and employment were significantly associated with better physical HRQoL (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .05). Participants reported low symptom burden, with fatigue most commonly reported. Neither CRS nor ICANS toxicity predicted long-term cognitive function or symptom burden.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Patients in long-term remission after CAR T-cell therapy have good HRQoL and cognitive function with minimal symptom burden. Importantly, there was no relationship between CRS and ICANS and long-term symptom burden or cognitive function. Results support the long-term clinical benefit of CAR T-cell therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/op-24-00823","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:59:07Z","timestamp":1747151947000},"page":"131-140","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":5,"title":["Long-Term Quality of Life, Cognitive Function, and Symptom Burden Among Chimeric Antigen Receptor T-Cell Recipients and Associated Cytokine Release Syndrome and Neurotoxicity"],"prefix":"10.1200","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8503-9929","authenticated-orcid":false,"given":"Lucy","family":"Andersen","sequence":"first","affiliation":[{"name":"Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, PA"},{"name":"Johnson and Johnson Innovative Medicine, Raritan, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan J.","family":"Quinn","sequence":"additional","affiliation":[{"name":"Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Difilippo","sequence":"additional","affiliation":[{"name":"Cell Therapy and Transplant Program, Abramson Cancer Center and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred L.","family":"Garfall","sequence":"additional","affiliation":[{"name":"Cell Therapy and Transplant Program, Abramson Cancer Center and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA"},{"name":"Division of Hematology and Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Porter","sequence":"additional","affiliation":[{"name":"Cell Therapy and Transplant Program, Abramson Cancer Center and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA"},{"name":"Division of Hematology and Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5866-8279","authenticated-orcid":false,"given":"Salimah H.","family":"Meghani","sequence":"additional","affiliation":[{"name":"Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Deng","sequence":"additional","affiliation":[{"name":"Biobehavioral Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2021.07.007"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.soncn.2021.151216"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2019.09.037"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2022.05.015"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2022.03.023"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000201083"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019001026"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(24)00005-X"},{"key":"e_1_3_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2023.107074"},{"key":"e_1_3_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.soncn.2024.151614"},{"key":"e_1_3_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2022.04.008"},{"key":"e_1_3_8_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022007676"},{"key":"e_1_3_8_14_2","first-page":"61","article-title":"Paying research participants: Regulatory uncertainty, conceptual confusion, and a path forward","volume":"17","author":"Largent EA","year":"2017","unstructured":"Largent EA, Fernandez Lynch H: Paying research participants: Regulatory uncertainty, conceptual confusion, and a path forward. Yale J Health Policy Law Ethics 17:61-141, 2017","journal-title":"Yale J Health Policy Law Ethics"},{"key":"e_1_3_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.12.758"},{"key":"e_1_3_8_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s41687-017-0003-8"},{"key":"e_1_3_8_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s41687-023-00591-x"},{"key":"e_1_3_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.05.009"},{"key":"e_1_3_8_19_2","volume-title":"PROMIS Score Cut Points","author":"HealthMeasures","year":"2024","unstructured":"HealthMeasures: PROMIS Score Cut Points. NIH, Bethesda, MD, 2024"},{"key":"e_1_3_8_20_2","volume-title":"Meaningful Change for PROMIS","author":"HealthMeasures","year":"2024","unstructured":"HealthMeasures: Meaningful Change for PROMIS. NIH, Bethesda, MD, 2024"},{"key":"e_1_3_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2022.05.004"},{"key":"e_1_3_8_22_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2022-163194"},{"key":"e_1_3_8_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26596"},{"key":"e_1_3_8_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/jncics\/pkaa123"},{"key":"e_1_3_8_25_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2021.752868"},{"key":"e_1_3_8_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2023.09.011"},{"key":"e_1_3_8_27_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023020578"},{"key":"e_1_3_8_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.14100"},{"key":"e_1_3_8_29_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12113453"},{"key":"e_1_3_8_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apnu.2013.12.005"},{"key":"e_1_3_8_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-022-00629-1"},{"key":"e_1_3_8_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.10.478"},{"key":"e_1_3_8_33_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-17-0698"},{"key":"e_1_3_8_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-023-00754-1"},{"key":"e_1_3_8_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2024.01.074"},{"key":"e_1_3_8_36_2","article-title":"Black race linked to inferior outcomes among younger patients receiving CAR-T for ALL","author":"Amorosi D","year":"2021","unstructured":"Amorosi D: Black race linked to inferior outcomes among younger patients receiving CAR-T for ALL. Hematology\/Oncology, February 15, 2021","journal-title":"Hematology\/Oncology"}],"container-title":["JCO Oncology Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/OP-24-00823","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T22:59:23Z","timestamp":1768345163000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/OP-24-00823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1200\/OP-24-00823"],"URL":"https:\/\/doi.org\/10.1200\/op-24-00823","relation":{},"ISSN":["2688-1527","2688-1535"],"issn-type":[{"value":"2688-1527","type":"print"},{"value":"2688-1535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2024-10-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-22","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}