{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T08:58:05Z","timestamp":1793177885408,"version":"4.5.0"},"reference-count":14,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"10","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Oncol Pract"],"published-print":{"date-parts":[[2025,10]]},"abstract":"\n PURPOSE<\/jats:title>\n The Anal Cancer\/High-grade squamous intraepithelial lesions Outcomes Research (ANCHOR) trial demonstrated that treating precancerous anal HSIL reduces the incidence of anal cancer by 57% in people with HIV. It remains unclear how HSIL treatment or monitoring without treatment affects patient-reported health-related quality of life (HRQoL). We evaluated differences in HRQoL for individuals who were randomly assigned to active monitoring (AM) or treatment for anal HSIL.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n Using an index designed and validated for use in ANCHOR, HRQoL was assessed before random assignment (T1), 2-7 days (+3 days) after random assignment\/treatment (T2), and 28 days (\u00b17 days) after random assignment\/treatment (T3).<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n ANCHOR participants living with HIV (N = 124; mean [standard deviation, SD] age, 52.6 years [10.3]; n = 101 [81.5%] men; n = 65 [52.4%] White; n = 95 [76.6%] non-Hispanic; treatment n = 70 [56.4%]; and AM n = 54 [43.6%]) were included. Treatment arm participants had significant mean worsening from T1-T2 in physical symptoms (mean [SD] difference, 0.31 [0.51];\n P<\/jats:italic>\n = .0001) and impact on psychological functioning (mean [SD] difference, 0.25 [0.64];\n P<\/jats:italic>\n = .022) that significantly improved to T1 levels from T2-T3 (ie, mean [SD] difference, \u20130.25 [0.52];\n P<\/jats:italic>\n = .003; and mean [SD] difference, \u20130.07 [0.23];\n P<\/jats:italic>\n = .039, respectively). AM arm participants experienced significant mean improvement in impact on psychological functioning from T1-T3 (mean [SD], difference, \u20130.20 [0.50];\n P<\/jats:italic>\n = .017). After adjusting for T1, treatment arm participants had a larger mean improvement than AM arm participants in physical symptoms from T2-T3 (mean [SD] difference, \u20130.25 [0.52];\n P<\/jats:italic>\n = .024); no between-arm differences were observed for impact on physical or psychological functioning.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n Treatment arm participants experienced significant worsening in physical symptoms and impact on psychological functioning from T1-T2 but returned to prerandomization levels by T3, indicating that any immediate anal HSIL treatment-related impacts to HRQoL are temporary. Further research is needed to determine long-term impacts of anal HSIL treatment on HRQoL.<\/jats:p>\n <\/jats:sec>","DOI":"10.1200\/op-24-00830","type":"journal-article","created":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T15:59:10Z","timestamp":1741276750000},"page":"1475-1482","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":4,"title":["Health-Related Quality of Life for Persons Treated or Monitored for Anal High-Grade Squamous Intraepithelial Lesions (AMC-A01)"],"prefix":"10.1200","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4965-3913","authenticated-orcid":false,"given":"Thomas M.","family":"Atkinson","sequence":"first","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3965-5146","authenticated-orcid":false,"given":"Madhu","family":"Mazumdar","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Van Hyfte","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3536-2442","authenticated-orcid":false,"given":"Jeannette Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences, Little Rock, AR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6571-3587","authenticated-orcid":false,"given":"Yuelin","family":"Li","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2174-1604","authenticated-orcid":false,"given":"Kathleen A.","family":"Lynch","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, NY"},{"name":"School of Global Public Health, New York University, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0377-1754","authenticated-orcid":false,"given":"Andrew","family":"Webb","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Holland","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica I.","family":"Lubetkin","sequence":"additional","affiliation":[{"name":"CUNY School of Medicine, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Goldstone","sequence":"additional","affiliation":[{"name":"Laser Surgery Care, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark H.","family":"Einstein","sequence":"additional","affiliation":[{"name":"Montefiore Medical Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3526-0032","authenticated-orcid":false,"given":"Elizabeth A.","family":"Stier","sequence":"additional","affiliation":[{"name":"Boston Medical Center, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9416-473X","authenticated-orcid":false,"given":"Dorothy J.","family":"Wiley","sequence":"additional","affiliation":[{"name":"School of Nursing, University of California, Los Angeles, Los Angeles, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Mitsuyasu","sequence":"additional","affiliation":[{"name":"UCLA Center for Clinical AIDS Research and Education, Los Angeles, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Rosa-Cunha","sequence":"additional","affiliation":[{"name":"University of Miami, Miami, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6752-3530","authenticated-orcid":false,"given":"David M.","family":"Aboulafia","sequence":"additional","affiliation":[{"name":"Virginia Mason Medical Center, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shireesha","family":"Dhanireddy","sequence":"additional","affiliation":[{"name":"Harborview Medical Center, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey T.","family":"Schouten","sequence":"additional","affiliation":[{"name":"Virginia Mason Medical Center, Seattle, WA"},{"name":"Harborview Medical Center, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Levine","sequence":"additional","affiliation":[{"name":"Montefiore Medical Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2324-1141","authenticated-orcid":false,"given":"Edward M.","family":"Gardner","sequence":"additional","affiliation":[{"name":"Public Health Institute at Denver Health, Denver, CO"},{"name":"University of Colorado Hospital, Aurora, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hillary","family":"Dunlevy","sequence":"additional","affiliation":[{"name":"University of Colorado Hospital, Aurora, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis F.","family":"Barroso","sequence":"additional","affiliation":[{"name":"Atrium Health Wake Forest Baptist, Winston-Salem, 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