{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T11:24:31Z","timestamp":1767612271283,"version":"3.45.0"},"reference-count":23,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"11","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Oncol Pract"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>The recent improvement in the prognosis of blood cancers has focused attention toward fertility preservation. We aimed to provide real-world insights into sperm quality and rate of conception, both naturally and through assisted reproductive technology (ART), in men who stored their semen before treatments for hematologic cancers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIALS AND METHODS<\/jats:title>\n                    <jats:p>Patients with hematologic cancer who cryopreserved semen between 1987 and 2018 had a postbanking follow-up and survived for at least 5 years after therapies were included. A total of N = 464 patients were selected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Overall, n = 407 survived and n = 255 (63%) underwent a post-treatment sperm analysis, revealing azoospermia in 37% of them. Severe or very severe impairment of spermatogenesis was significantly more prevalent in men affected by leukemias than by lymphomas. About half of cancer survivors (n = 200) sought fatherhood. Seventy-three achieved a natural live birth (37%). Forty-six percent of individuals seeking pregnancy used their cryopreserved samples in ART cycles, resulting in at least one live birth in 52% of them. Overall, 120 of 200 men (60%; 95% CI, 53 to 67) interested in fatherhood successfully had a live birth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Treatments for hematologic cancer have a detrimental impact on semen quality. Semen preserved before therapies and ART are critical for fulfilling the common desire of parenthood in hematologic cancer survivors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/op-24-00888","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T15:59:48Z","timestamp":1744127988000},"page":"1695-1701","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Natural and Assisted Conceptions in Male Patients With Blood Cancers Who Stored Their Semen for Fertility Preservation"],"prefix":"10.1200","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9868-3043","authenticated-orcid":false,"given":"Marco","family":"Reschini","sequence":"first","affiliation":[{"name":"Infertility Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Sanzani","sequence":"additional","affiliation":[{"name":"Infertility Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Tondo","sequence":"additional","affiliation":[{"name":"Infertility Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6961-6895","authenticated-orcid":false,"given":"Mattia","family":"Volpi","sequence":"additional","affiliation":[{"name":"Infertility Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3674-5912","authenticated-orcid":false,"given":"Paola","family":"Vigano'","sequence":"additional","affiliation":[{"name":"Infertility Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0223-0032","authenticated-orcid":false,"given":"Edgardo","family":"Somigliana","sequence":"additional","affiliation":[{"name":"Infertility Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Italy"},{"name":"Urology Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0636-2876","authenticated-orcid":false,"given":"Francesca","family":"Filippi","sequence":"additional","affiliation":[{"name":"Infertility Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Boeri","sequence":"additional","affiliation":[{"name":"Infertility Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2020.0157"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21590"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.78.1914"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13010116"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/1758834016665078"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1240152"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.180061"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1252433"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.02714"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2016.04.002"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12894"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.4103\/aja202289"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2021.03.041"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-022-01712-8"},{"key":"e_1_3_7_16_2","volume-title":"Laboratory Manual for the Examination of Human Semen and Semen Cervical Mucus Interaction","author":"WHO","year":"1987","unstructured":"WHO: Laboratory Manual for the Examination of Human Semen and Semen Cervical Mucus Interaction. 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