{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T12:42:06Z","timestamp":1791636126274,"version":"4.3.4"},"reference-count":62,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"4","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Oncol Pract"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>Evaluate the longitudinal relationship between financial toxicity (FT), health-related quality of life (HR-QOL), and psychological distress for patients with cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Adults with cancer applying for foundation financial assistance or receiving treatment participated in a longitudinal survey study at any point in their cancer journey and 1, 3, and 6 months later. Validated surveys measured FT (Comprehensive Score for FT [COST]), HR-QOL (Functional Assessment of Cancer Therapy-General [FACT-G]), and psychological distress (Brief-Profile of Mood States [Brief-POMS]). Multilevel ordinal logistic and linear regression models assessed longitudinal relationships.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Out of 1,112 approached, 732 (66%) completed the enrollment survey with subsequent response rates of 66%, 58%, and 52% at 1, 3, and 6 months, respectively. Participants had a mean age of 68 years. Most were non-Hispanic White (86%), male (57%), Medicare beneficiaries (82%), and had hematologic malignancies (53%). Most common cancer types were multiple myeloma and prostate cancer. Most (80%) had FT at enrollment (grade 1+ or COST &lt;26), and FT was higher in earlier calendar months. Access to a financial counselor was associated with lower FT for those who desired a referral (adjusted odds ratio [aOR], 0.18). Previous (OR, 1.58) and current (OR, 1.73) intravenous chemotherapy were associated with higher FT. In multivariable multilevel models clustered by participants, higher FT was significantly associated with lower HR-QOL and greater psychological distress. The probability of any FT decreased from 79% at enrollment to 72% at 1 month and 68% at 3 and 6 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Patients with various cancer types had associations between higher FT, lower HR-QOL, and more psychological distress across repeated measures over 6-month intervals. FT screening should be repeated across the cancer care continuum, especially early in the calendar year. This will allow interventions to improve patients' emotional and physical well-being.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/op-24-00917","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T15:59:49Z","timestamp":1751299189000},"page":"675-685","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":6,"title":["Longitudinal Associations Between Financial Toxicity and Health-Related Quality of Life for Patients With Cancer"],"prefix":"10.1200","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5202-1231","authenticated-orcid":false,"given":"Austin","family":"Wesevich","sequence":"first","affiliation":[{"name":"Section of Hematology\/Oncology, Department of Medicine, University of Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Dadwani","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Pediatrics, University of Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8134-6094","authenticated-orcid":false,"given":"Donald","family":"Hedeker","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, University of Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2808-722X","authenticated-orcid":false,"given":"Daniel W.","family":"Golden","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Rush University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4587-5444","authenticated-orcid":false,"given":"Rohan R.","family":"Katipally","sequence":"additional","affiliation":[{"name":"Department of Radiation and Cellular Oncology, University of Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica E.","family":"Peek","sequence":"additional","affiliation":[{"name":"Section of General Internal Medicine, Department of Medicine, University of Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vineet M.","family":"Arora","sequence":"additional","affiliation":[{"name":"The Pritzker School of Medicine, Biological Sciences Division, University of Chicago"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/tbm\/ibab091"},{"key":"e_1_3_6_3_2","first-page":"80","article-title":"Financial toxicity, Part I: A new name for a growing problem","volume":"27","author":"Zafar SY","year":"2013","unstructured":"Zafar SY, Abernethy AP: Financial toxicity, Part I: A new name for a growing problem. 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