{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T08:55:47Z","timestamp":1783414547578,"version":"3.54.6"},"reference-count":16,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"2","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Oncol Pract"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>Effective methods to improve body composition and metabolic\/hormonal dysregulation are central to breast cancer care. We hypothesized that a nutrition regimen focused on food quality and an observed exercise regimen using high-load resistance training during or after cancer treatment would improve body composition and functional capacity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Forty-four women with breast cancer, including survivors on therapy and in surveillance, excluding chemotherapy, underwent a continuously monitored dose-escalated exercise regimen utilizing heavy weights and linear progression in an exercise oncology facility along with a diet focused on food quality and adequate protein intake. Dietary strategy was discussed during each exercise session and twice monthly meetings. Pre- and post-workout assessment of body composition, functional mobility, balance, activity levels, and quality of life were compared via paired\n                      <jats:italic toggle=\"yes\">T<\/jats:italic>\n                      -test and Wilcoxon signed-rank test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Forty-four women completed the protocol, with a median age of 54 years and BMI of 30.3. Most participants reported cancer-related symptoms (79.5%). Across compound exercises, composite load lifted increased by 36.5% (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001) and bilateral Y-balance scores increased 18% (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001). A 6.6% reduction in body fat was observed (1.8 kg;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001) alongside a 1.4% increase in muscle mass (0.5 kg;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .003). Resting metabolic rate increased by 0.8% (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .018). Significant improvements were uniformly demonstrated across quality-of-life scores (European Quality of Life 5-Dimension Score, Patient Health Questionnaire 9 Depression Scale, and Generalized Anxiety Disorder 7 questionnaires).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>A 3-month regimen of nutrition counseling and high-intensity resistance training promoted significant muscle mass gain and adipose tissue loss, alongside significant improvements across body composition, strength, mobility, and functional status, and patient-reported quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/op-24-00954","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T15:59:07Z","timestamp":1746633547000},"page":"255-262","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":6,"title":["EXERT-BCN: An Exercise Regimen Designed to Improve Body Composition, Functional Capacity, and Strength After Treatment for Breast Cancer With Nutrition Optimization"],"prefix":"10.1200","volume":"22","clinical-trial-number":[{"clinical-trial-number":"nct05978960","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"David J.","family":"Carpenter","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, WellStar Paulding Medical Center, Hiram, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Peluso","sequence":"additional","affiliation":[{"name":"Allegheny Health Network Cancer Institute Exercise Oncology and Resiliency Center, Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christie","family":"Hilton","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Allegheny Health Network, Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne B.","family":"Coopey","sequence":"additional","affiliation":[{"name":"Department of Surgery, Allegheny Health Network, Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janette","family":"Gomez","sequence":"additional","affiliation":[{"name":"Department of Surgery, Allegheny Health Network, Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1791-6790","authenticated-orcid":false,"given":"Jared","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Department of Exercise Science, Syracuse University, Syracuse, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4920-4595","authenticated-orcid":false,"given":"Sushil","family":"Beriwal","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Allegheny Health Network, Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parker N.","family":"Hyde","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, University of North Georgia, Dahlonega, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1879-7463","authenticated-orcid":false,"given":"Colin E.","family":"Champ","sequence":"additional","affiliation":[{"name":"Allegheny Health Network Cancer Institute Exercise Oncology and Resiliency Center, Pittsburgh, PA"},{"name":"Department of Radiation Oncology, Allegheny Health Network, Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1408"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/506868"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.0137"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.0245"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-022-01759-z"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.7001"},{"key":"e_1_3_6_8_2","first-page":"a21930922","article-title":"EXERT-BC: Prospective study of an exercise regimen after treatment for breast cancer","volume":"8","author":"Champ CE","year":"2024","unstructured":"Champ CE, Peluso C, Carenter DJ, et al: EXERT-BC: Prospective study of an exercise regimen after treatment for breast cancer. Sports Med Int Open 8:a21930922, 2024","journal-title":"Sports Med Int Open"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-020-00743-y"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.37780"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12966-019-0787-4"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-021-01542-6"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0000000000003996"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/02640414.2016.1210197"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.00687"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/2047487317713329"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-198806040-00006"}],"container-title":["JCO Oncology Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/OP-24-00954","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T22:59:30Z","timestamp":1770937170000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/OP-24-00954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1200\/OP-24-00954"],"URL":"https:\/\/doi.org\/10.1200\/op-24-00954","relation":{},"ISSN":["2688-1527","2688-1535"],"issn-type":[{"value":"2688-1527","type":"print"},{"value":"2688-1535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2024-11-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-20","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}