{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T18:19:21Z","timestamp":1789323561515,"version":"build-2803163510"},"reference-count":83,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"1","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Oncol Pract"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>Chemotherapy-induced peripheral neuropathy (CIPN) can have deleterious effects on mobility and quality of life in people with cancer. Vibration therapy shows promise as a CIPN intervention but is understudied. We investigated the feasibility and preliminary efficacy of low-intensity vibration (LIV) in cancer survivors with CIPN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We conducted a pilot randomized controlled trial in adult cancer survivors with persistent CIPN symptoms. Participants were randomly assigned to twice-daily LIV sessions (10 min\/session; 30 Hz, 0.4 g) for 12 weeks or usual care (UC). We assessed feasibility by accrual, retention, adherence, and adverse event (AE) reporting. We evaluated preliminary efficacy by changes in patient-reported CIPN symptoms (Functional Assessment of Cancer Therapy\/Gynecologic Oncology Group Neurotoxicity), pain (Brief Pain Inventory), fatigue (Patient-Reported Outcome Measurement Information System Fatigue), and physical functioning (Late-Life Function and Disability Instrument) and objectively measured physical functioning (chair stand time, gait speed), stability (postural sway), and mobility (Timed-Up-and-Go). Linear regression models were used to generate effect size estimates (Cohen's d).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>We accrued 95% of our target sample (n = 38, mean age: 62.6 \u00b1 9.9 years, 89% female, median time since chemotherapy completion: 18 [6-39] months), with 20 participants randomly assigned to LIV and 18 to UC. Trial retention was 97% and mean adherence to LIV was 77% \u00b1 18%. There were no serious AEs. Compared with UC, LIV participants reported greater improvements in sensory neuropathy symptoms (LIV, +1.4 \u00b1 3.3 points; UC, +0.2 \u00b1 2.8 points; Cohen's d = 0.45) and basic lower extremity function (LIV, +5.3 \u00b1 8.5 points; UC, \u20130.7 \u00b1 9.2 points; Cohen's d = 0.80), with moderate-to-large effect sizes for changes in stability, mobility, and gait (Cohen's d = 0.60-0.66).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>LIV is safe, feasible, and shows preliminary efficacy for CIPN symptom relief and improving physical functioning in cancer survivors with CIPN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/op-24-00961","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T15:59:39Z","timestamp":1747324779000},"page":"100-111","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":3,"title":["Low-Intensity Vibration to Reduce Symptoms and Improve Physical Functioning in Cancer Survivors With Chemotherapy-Induced Peripheral Neuropathy: A Pilot Randomized Trial"],"prefix":"10.1200","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0507-4669","authenticated-orcid":false,"given":"Stephanie M.","family":"Krasnow","sequence":"first","affiliation":[{"name":"Division of Oncological Sciences, Knight Cancer Institute, School of Medicine, Oregon Health &amp; Science University, Portland, OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0909-7999","authenticated-orcid":false,"given":"Clinton T.","family":"Rubin","sequence":"additional","affiliation":[{"name":"Stony Brook University, Stony Brook, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3674-3573","authenticated-orcid":false,"given":"Eric J.","family":"Roeland","sequence":"additional","affiliation":[{"name":"Division of Oncological Sciences, Knight Cancer Institute, School of Medicine, Oregon Health &amp; Science University, Portland, OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fay B.","family":"Horak","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medicine, Oregon Health &amp; Science University, Portland, OR"},{"name":"Clario APDM Precision Motion, Portland, OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6755-0902","authenticated-orcid":false,"given":"Sydnee A.","family":"Stoyles","sequence":"additional","affiliation":[{"name":"School of Nursing, Oregon Health &amp; Science University, Portland, OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5061-9889","authenticated-orcid":false,"given":"Nathan F.","family":"Dieckmann","sequence":"additional","affiliation":[{"name":"School of Nursing, Oregon Health &amp; Science University, Portland, OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendra N.","family":"Braun","sequence":"additional","affiliation":[{"name":"Division of Oncological Sciences, Knight Cancer Institute, School of Medicine, Oregon Health &amp; Science University, Portland, OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1706-8020","authenticated-orcid":false,"given":"Kerri M.","family":"Winters-Stone","sequence":"additional","affiliation":[{"name":"Division of Oncological Sciences, Knight Cancer Institute, School of Medicine, Oregon Health &amp; Science University, Portland, OR"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.0914"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0000000000000139"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-6352-3"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-016-3939-0"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.12788\/jcso.0086"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2014.09.020"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-018-3664-y"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-015-0810-y"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.01399"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/jfmk7040099"},{"key":"e_1_3_7_12_2","first-page":"187","article-title":"Whole-body vibration and rehabilitation of chronic diseases: A review of the literature","volume":"11","author":"Chanou K","year":"2012","unstructured":"Chanou K, Gerodimos V, Karatrantou K, et al: Whole-body vibration and rehabilitation of chronic diseases: A review of the literature. J Sports Sci Med 11:187-200, 2012","journal-title":"J Sports Sci Med"},{"key":"e_1_3_7_13_2","first-page":"263","article-title":"Whole-body vibration as a modality for the rehabilitation of peripheral neuropathies: Implications for cancer survivors suffering from chemotherapy-induced peripheral neuropathy","volume":"9","author":"Verhulst AL","year":"2015","unstructured":"Verhulst AL, Savelberg HH, Vreugdenhil G, et al: Whole-body vibration as a modality for the rehabilitation of peripheral neuropathies: Implications for cancer survivors suffering from chemotherapy-induced peripheral neuropathy. Oncol Rev 9:263, 2015","journal-title":"Oncol Rev"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40200-019-00476-1"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbmt.2020.01.004"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40200-015-0173-y"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.231.305"},{"key":"e_1_3_7_18_2","volume-title":"Mechanical Vibration and Shock. Evaluation of Human Exposure to Whole-Body Vibration","author":"ISO 2631-1:1997","year":"1997","unstructured":"ISO 2631-1:1997: Mechanical Vibration and Shock. Evaluation of Human Exposure to Whole-Body Vibration. Geneva, International Organization for Standardization, 1997"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsams.2013.01.004"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2009.05.005"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.080315"},{"key":"e_1_3_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsams.2013.01.004"},{"key":"e_1_3_7_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000000644"},{"key":"e_1_3_7_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0194720"},{"key":"e_1_3_7_25_2","first-page":"419","article-title":"A pilot study of low-intensity vibration training to reduce symptoms and improve gait and stability in cancer survivors with chemotherapy-induced peripheral neuropathy (NCT04170075)","volume":"38","author":"Winters-Stone K","year":"2023","unstructured":"Winters-Stone K, Braun K, Chan B, Krasnow S, et al: A pilot study of low-intensity vibration training to reduce symptoms and improve gait and stability in cancer survivors with chemotherapy-induced peripheral neuropathy (NCT04170075). J Bone Miner Res 38:419, 2023 (abstr)","journal-title":"J Bone Miner Res"},{"key":"e_1_3_7_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-020-01493-y"},{"key":"e_1_3_7_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2007.00794.x"},{"key":"e_1_3_7_28_2","doi-asserted-by":"publisher","DOI":"10.1177\/0163278705275340"},{"key":"e_1_3_7_29_2","doi-asserted-by":"publisher","DOI":"10.1054\/jpai.2003.1"},{"key":"e_1_3_7_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2007.09.005"},{"key":"e_1_3_7_31_2","volume-title":"Patient-Reported Outcomes Measurement Information System: PROMIS Fatigue Scoring Manual","year":"2019","unstructured":"Patient-Reported Outcomes Measurement Information System: PROMIS Fatigue Scoring Manual. 2019. https:\/\/www.healthmeasures.net\/images\/PROMIS\/manuals\/Scoring_Manuals_\/PROMIS_Fatigue_Scoring_Manual.pdf"},{"key":"e_1_3_7_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.04.011"},{"key":"e_1_3_7_33_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.2341"},{"key":"e_1_3_7_34_2","first-page":"119","article-title":"Psychometric evaluation of the PROMIS Fatigue measure in an ethnically and racially diverse population-based sample of cancer patients","volume":"58","author":"Reeve BB","year":"2016","unstructured":"Reeve BB, Pinheiro LC, Jensen RE, et al: Psychometric evaluation of the PROMIS Fatigue measure in an ethnically and racially diverse population-based sample of cancer patients. Psychol Test Assess Model 58:119-139, 2016","journal-title":"Psychol Test Assess Model"},{"key":"e_1_3_7_35_2","doi-asserted-by":"publisher","DOI":"10.1097\/NNR.0000000000000162"},{"key":"e_1_3_7_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.11.018"},{"key":"e_1_3_7_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gly230"},{"key":"e_1_3_7_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/49.2.M85"},{"key":"e_1_3_7_39_2","doi-asserted-by":"publisher","DOI":"10.1111\/jep.12158"},{"key":"e_1_3_7_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2006.00701.x"},{"key":"e_1_3_7_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afn100"},{"key":"e_1_3_7_42_2","first-page":"007","article-title":"Mobility lab to assess balance and gait with synchronized body-worn sensors","volume":"1","author":"Mancini M","year":"2011","unstructured":"Mancini M, King L, Salarian A, et al: Mobility lab to assess balance and gait with synchronized body-worn sensors. J Bioeng Biomed Sci 1:007, 2011","journal-title":"J Bioeng Biomed Sci"},{"key":"e_1_3_7_43_2","doi-asserted-by":"publisher","DOI":"10.1186\/1743-0003-9-59"},{"key":"e_1_3_7_44_2","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6579\/ab4023"},{"key":"e_1_3_7_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2019.01.025"},{"key":"e_1_3_7_46_2","first-page":"239","article-title":"The relevance of clinical balance assessment tools to differentiate balance deficits","volume":"46","author":"Mancini M","year":"2010","unstructured":"Mancini M, Horak FB: The relevance of clinical balance assessment tools to differentiate balance deficits. Eur J Phys Rehabil Med 46:239-248, 2010","journal-title":"Eur J Phys Rehabil Med"},{"key":"e_1_3_7_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/80.9.896"},{"key":"e_1_3_7_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2010.02820.x"},{"key":"e_1_3_7_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2007.05.007"},{"key":"e_1_3_7_50_2","doi-asserted-by":"publisher","DOI":"10.21105\/joss.02815"},{"key":"e_1_3_7_51_2","volume-title":"Statistical Power Analysis for Behavioral Sciences","author":"Cohen J","year":"1988","unstructured":"Cohen J: Statistical Power Analysis for Behavioral Sciences (ed 2). Lawrence Erlbaum Associates, Hillsdale, NJ, 1988","edition":"2"},{"key":"e_1_3_7_52_2","volume-title":"A Language and Environment for Statistical Computing","author":"R","year":"2022","unstructured":"R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria, 2022"},{"key":"e_1_3_7_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2021.07.010"},{"key":"e_1_3_7_54_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.71.3552"},{"key":"e_1_3_7_55_2","doi-asserted-by":"publisher","DOI":"10.3122\/jabfm.17.5.309"},{"key":"e_1_3_7_56_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2009.02914.x"},{"key":"e_1_3_7_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2020.02.009"},{"key":"e_1_3_7_58_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm4.10685"},{"key":"e_1_3_7_59_2","first-page":"318","article-title":"The effects of whole body vibration on mobility and balance in Parkinson disease: A systematic review","volume":"39","author":"Sharififar S","year":"2014","unstructured":"Sharififar S, Coronado RA, Romero S, et al: The effects of whole body vibration on mobility and balance in Parkinson disease: A systematic review. Iran J Med Sci 39:318-326, 2014","journal-title":"Iran J Med Sci"},{"key":"e_1_3_7_60_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/719082"},{"key":"e_1_3_7_61_2","doi-asserted-by":"publisher","DOI":"10.1177\/1479972315583049"},{"key":"e_1_3_7_62_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2024.1295776"},{"key":"e_1_3_7_63_2","doi-asserted-by":"publisher","DOI":"10.1179\/107902610x12886261091758"},{"key":"e_1_3_7_64_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12391"},{"key":"e_1_3_7_65_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4229"},{"key":"e_1_3_7_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2017.05.014"},{"key":"e_1_3_7_67_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-004-1637-y"},{"key":"e_1_3_7_68_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-12-171"},{"key":"e_1_3_7_69_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2015.6557"},{"key":"e_1_3_7_70_2","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.0301251"},{"key":"e_1_3_7_71_2","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.040129"},{"key":"e_1_3_7_72_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.060612"},{"key":"e_1_3_7_73_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2448"},{"key":"e_1_3_7_74_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25431"},{"key":"e_1_3_7_75_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2024.2354"},{"key":"e_1_3_7_76_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-018-4531-4"},{"key":"e_1_3_7_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2010.12.019"},{"key":"e_1_3_7_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2004.05.019"},{"key":"e_1_3_7_79_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc23-1858"},{"key":"e_1_3_7_80_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/32.2.137"},{"key":"e_1_3_7_81_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.22649.1"},{"key":"e_1_3_7_82_2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.14156"},{"key":"e_1_3_7_83_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-43985-9_9"},{"key":"e_1_3_7_84_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.160"}],"container-title":["JCO Oncology Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/OP-24-00961","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T22:59:49Z","timestamp":1768345189000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/OP-24-00961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":83,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1200\/OP-24-00961"],"URL":"https:\/\/doi.org\/10.1200\/op-24-00961","relation":{},"ISSN":["2688-1527","2688-1535"],"issn-type":[{"value":"2688-1527","type":"print"},{"value":"2688-1535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2024-11-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-10","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}