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ASCO Guidelines follow the<\/jats:italic>\n \n ASCO Conflict of Interest Policy for Clinical Practice Guidelines<\/jats:italic>\n <\/jats:ext-link>\n .\n <\/jats:p>\n \n \n Clinical Practice Guidelines and other guidance (\u201cGuidance\u201d) provided by ASCO is not a comprehensive or definitive guide to treatment options. It is intended for voluntary use by clinicians and should be used in conjunction with independent professional judgment. Guidance may not be applicable to all patients, interventions, diseases or stages of diseases. Guidance is based on review and analysis of relevant literature and is not intended as a statement of the standard of care. ASCO does not endorse third-party drugs, devices, services, or therapies and assumes no responsibility for any harm arising from or related to the use of this information. See complete disclaimer in\n Appendix 1<\/jats:xref>\n and\n 2<\/jats:xref>\n (online only) for more.\n <\/jats:italic>\n <\/jats:p>\n \n PURPOSE<\/jats:title>\n To develop a clinical practice guideline and recommendations for symptom management of patients with well-differentiated grade 1 to grade 3 metastatic gastroenteropancreatic neuroendocrine tumors.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n ASCO convened an Expert Panel to develop a clinical practice guideline by reviewing the literature for relevant guidelines, systematic reviews, randomized controlled trials (RCTs), and observational studies to develop recommendations for clinical practice.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n The literature review identified eight guidelines, 19 systematic reviews, and three RCTs that informed the development of guideline recommendations.<\/jats:p>\n <\/jats:sec>\n \n RECOMMENDATIONS<\/jats:title>\n Recommendations are included for carcinoid syndrome, carcinoid heart disease and carcinoid crisis, and functional pancreatic neuroendocrine tumor syndromes. Recommendations are provided for surgical management, liver-directed therapy, and systemic therapy options, as well as palliative care. Limited guidance is provided for sequencing of interventions.<\/jats:p>\n \n Additional information is available at\n www.asco.org\/gastrointestinal-cancer-guidelines<\/jats:ext-link>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1200\/op-25-00133","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T15:59:37Z","timestamp":1746806377000},"page":"19-35","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":26,"title":["Symptom Management for Well-Differentiated Gastroenteropancreatic Neuroendocrine Tumors: ASCO Guideline"],"prefix":"10.1200","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5745-2994","authenticated-orcid":true,"given":"Kimberly","family":"Perez","sequence":"first","affiliation":[{"name":"Dana-Farber Cancer Institute, Boston, 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