{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T09:59:49Z","timestamp":1784368789758,"version":"3.55.0"},"reference-count":14,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"7","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Oncol Pract"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>\n                      A provider's participation in a randomized clinical trial (RCT) may influence their use of the trial intervention outside of trial contexts. We explored the association between site-level participation in a trial evaluating a postradical prostatectomy (RP) genomic classifier (GC; Genomics in Michigan Impacting Observation or Radiation [G-MINOR], ClinicalTrials.gov identifier:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT02783950\">NCT02783950<\/jats:ext-link>\n                      ) and use of post-RP GC after completion of the trial's enrollment window.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The Michigan Urological Surgery Improvement Collaborative (MUSIC) data registry, in which G-MINOR was embedded, was queried for G-MINOR\u2013eligible patients outside of the trial context (nonparticipating sites, chronology). A logistic regression model compared time with a patient's receipt of post-RP GC testing at G-MINOR participating and nonparticipating sites, before and after the trial's enrollment window.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      A total of 7,144 patients (5,822 at G-MINOR sites, 1,322 non\u2013G-MINOR sites) met study inclusion criteria between October 2015 and October 2020. Post-RCT, GC testing peaked among G-MINOR sites at 0.122 tests per eligible patient-quarter; no testing was observed among nonparticipating sites. Adjusting for patient characteristics, an interaction term between site-level RCT participation and pre-\/postenrollment was statistically significant (hazard ratio, 21.9 [95% CI, 3.57 to 134];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Site-level participation in the G-MINOR RCT was significantly associated with a differential change in post-RCT GC use, where trial sites showed a greater post-RCT increase compared with nontrial sites. Whether this is caused by trial participation or represents a pre-existing intention to adopt an intervention remains unknown. Implementation and deimplementation considerations should be included in trial design.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/op-25-00475","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T19:59:07Z","timestamp":1757620747000},"page":"1304-1311","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":1,"title":["How Sticky Are Clinical Trial Interventions? Site-Level Clinical Trial Participation and Differential Post-Trial Use of a Genomic Test"],"prefix":"10.1200","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0692-2909","authenticated-orcid":true,"given":"Patrick","family":"Lewicki","sequence":"first","affiliation":[{"name":"Department of Urology, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9940-4109","authenticated-orcid":true,"given":"Ralph","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3928-9476","authenticated-orcid":true,"given":"Udit","family":"Singhal","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6355-0710","authenticated-orcid":true,"given":"Stephanie","family":"Daignault-Newton","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Michigan, Ann Arbor, MI"},{"name":"Department of Biostatistics, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Ginsburg","sequence":"additional","affiliation":[{"name":"Department of Urology, Wayne State University, Detroit, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tudor","family":"Borza","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Schipper","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Michigan, Ann Arbor, MI"},{"name":"Department of Radiation Oncology, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Cher","sequence":"additional","affiliation":[{"name":"Department of Urology, Wayne State University, Detroit, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1140-0603","authenticated-orcid":true,"given":"Todd","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4917-2984","authenticated-orcid":true,"given":"Kristian","family":"Stensland","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Michigan, Ann Arbor, MI"},{"name":"Department of Learning Health Sciences, University of Michigan, Ann Arbor, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Michigan Urological Surgery Improvement Collaborative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15199"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.23.2759"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp2307585"},{"key":"e_1_3_7_5_2","volume-title":"Pew. The Role of Lab-Developed Tests in the in Vitro Diagnostics Market","year":"2025","unstructured":"Pew. The Role of Lab-Developed Tests in the in Vitro Diagnostics Market, 2025. https:\/\/pew.org\/3vuO3qC"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.943860"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.11.021"},{"key":"e_1_3_7_8_2","volume-title":"CMS Local Coverage Determination: Moldx-Cdd: Decipher\u00ae Prostate Cancer Classifier Assay","author":"CMS","year":"2015","unstructured":"CMS: CMS Local Coverage Determination: Moldx-Cdd: Decipher\u00ae Prostate Cancer Classifier Assay. 2015. https:\/\/localcoverage.cms.gov\/mcd_archive\/view\/lcd.aspx?lcdInfo=36341"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2024.09.011"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31553-1"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30456-3"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-149-4-200808190-00012"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13012-022-01247-y"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0b013e3182408812"},{"key":"e_1_3_7_15_2","volume-title":"Decipher Assist FAQ","year":"2024","unstructured":"Decipher Assist FAQ. 2024. https:\/\/decipherbio.com\/wp-content\/uploads\/2024\/01\/Decipher_Assist_FAQ_and_Application.pdf"}],"container-title":["JCO Oncology Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/OP-25-00475","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T21:59:35Z","timestamp":1784325575000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/OP-25-00475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1200\/OP-25-00475"],"URL":"https:\/\/doi.org\/10.1200\/op-25-00475","relation":{},"ISSN":["2688-1527","2688-1535"],"issn-type":[{"value":"2688-1527","type":"print"},{"value":"2688-1535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2025-05-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-20","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}