{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:45:46Z","timestamp":1792017946893,"version":"4.4.0"},"reference-count":54,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"10","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Oncol Pract"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>To develop and evaluate real-world interventions to move guidelines on timely palliative care utilization into practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A knowledge-to-action cycle theory\u2013informed, process improvement project facilitated implementation of a clinical practice guideline by (1) systematically screening clinic patients for unmet palliative care needs and alerting the oncologist, (2) using a dedicated community-based palliative care nurse for each referral, and (3) using Shared-care letters (structured communication between oncologist, family physician, and patient) to enhance information exchange and awareness of patients' needs. Implementation occurred for advanced colorectal cancer (CRC) within the GI clinics of the Tom Baker Cancer Center, Calgary, AB, Canada, and the neighboring city's Cross Cancer Institute, Edmonton, AB, Canada acted as control. The primary outcome was the proportion of adult decedents with CRC who received early specialist palliative care (SPC; defined as &gt;90 days before death), evaluated using a pragmatic, controlled, before-and-after study. Eligible decedents in each city were identified using provincial cancer registry data and linked with administrative data identifying palliative care consultation, homecare, hospice, or inpatient unit usage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The cohort included 695 decedents: 341 baseline period (153 control, 188 intervention, April 2017-December 2018) and 354 implementation period (145 control, 209 intervention, April 2019-December 2020); the mean age was 66.5 years, 60% was male, and 95.2% was urban-dwelling. In the intervention arm, the proportion of decedents who received palliative care &gt;90 days before death increased from 44.7% at baseline to 57.4% after implementation; in the control arm, the proportion decreased from 47.7% to 44.1% (17.7% difference in differences [95% CI, 3.1-32.4];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .018).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>This intervention effectively increased early SPC utilization and provides a pragmatic approach to achieve and measure system-level change.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/op-25-00492","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T20:59:35Z","timestamp":1765573175000},"page":"1719-1729","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Real-World Study of the Implementation of Early and Systematic Palliative Care for Advanced Colorectal Cancer Care\u2014The Palliative Care Early and Systematic Project"],"prefix":"10.1200","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0865-4231","authenticated-orcid":true,"given":"Jessica E.","family":"Simon","sequence":"first","affiliation":[{"name":"Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7519-4335","authenticated-orcid":true,"given":"Sharon M.","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Oncology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1497-8539","authenticated-orcid":false,"given":"Patricia A.","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2615-3019","authenticated-orcid":true,"given":"Marc","family":"Kerba","sequence":"additional","affiliation":[{"name":"Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada"},{"name":"Department of Family Practice, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madalene","family":"Earp","sequence":"additional","affiliation":[{"name":"Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada"},{"name":"Island Health, Victoria, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Piquette","sequence":"additional","affiliation":[{"name":"Alberta Health Services, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Vandale","sequence":"additional","affiliation":[{"name":"Alberta Health Services, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8088-5755","authenticated-orcid":true,"given":"Patricia","family":"Biondo","sequence":"additional","affiliation":[{"name":"Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Akude","sequence":"additional","affiliation":[{"name":"Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7967-159X","authenticated-orcid":true,"given":"Aynharan","family":"Sinnarajah","sequence":"additional","affiliation":[{"name":"Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada"},{"name":"Department of Medicine, Queens University, Kingston, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.24.00542"},{"key":"e_1_3_8_3_2","first-page":"e13620","article-title":"Effects of early palliative care on patients with incurable cancer: A meta-analysis and systematic review","volume":"31","author":"Huo B","year":"2022","unstructured":"Huo B, Song Y, Chang L, et al: Effects of early palliative care on patients with incurable cancer: A meta-analysis and systematic review. 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