{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T03:58:01Z","timestamp":1783569481765,"version":"3.55.0"},"reference-count":20,"publisher":"American Society of Clinical Oncology (ASCO)","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Oncol Pract"],"abstract":"\n PURPOSE<\/jats:title>\n \n Germline genetic testing is critical for guiding cancer treatment, identifying hereditary syndromes, and enabling cascade testing for at-risk relatives. However, barriers such as limited access to genetic counselors and long wait times may hinder its implementation. This study evaluates the Rapid Access Cancer Genetic Testing Program (\n Rapid<\/jats:italic>\n ), a streamlined workflow incorporating a pretest video education (VE) process navigation by genetic testing coordinators (GTCs), and targeted involvement of genetic counselors and physicians for patients with pathogenic or likely pathogenic (P\/LP) results.\n <\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n \n A retrospective review of 2,767 oncology patients who participated in\n Rapid<\/jats:italic>\n between May 2021 and May 2023 was conducted. Eligible patients had breast, prostate, pancreatic, ovarian, or colorectal cancer and met National Comprehensive Cancer Network testing guidelines.\n Rapid<\/jats:italic>\n visits included VE, pedigree collection, consenting, and genetic testing coordination by GTCs. Patients with P\/LP results were seen for follow-up by genetic counselors and cancer genetics physicians.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n Of the 2,767 patients, 89.1% consented to genetic testing, and 87.9% completed testing. Among those tested, 13.2% had P\/LP variants, with those in\n BRCA2, BRCA1,<\/jats:italic>\n and\n CHEK2<\/jats:italic>\n being the most frequently identified. Disparities in testing completion were observed, with older age (\u226550 years), Black or African American race, and pancreatic cancer diagnosis associated with lower odds of testing. Pancreatic and prostate cancer diagnoses, as well as recessive genetic findings, were associated with lower follow-up rates.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n \n Rapid<\/jats:italic>\n demonstrated high genetic testing uptake and effective integration into oncology workflows, enabling timely treatment decisions. Although the program optimized resource use and reduced barriers, disparities in testing remain. Future efforts should address these inequities and evaluate the long-term impact of genetic testing on patient outcomes.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1200\/op-25-01367","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T19:59:09Z","timestamp":1778183949000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Video Education With Clinical Genetic Testing Coordinators for the\n Rapid<\/i>\n Evaluation of Patients With Cancers: Real-World Evidence"],"prefix":"10.1200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7724-3471","authenticated-orcid":true,"given":"Jill E.","family":"Stopfer","sequence":"first","affiliation":[{"name":"Division of Cancer Genetics and Prevention, Dana-Farber Cancer Institute, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9800-1954","authenticated-orcid":true,"given":"Miki","family":"Horiguchi","sequence":"additional","affiliation":[{"name":"Department of Data Science, Dana-Farber Cancer Institute, Boston, MA"},{"name":"Department of Biostatistics, T.H. Chan School of Public Health, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7037-3430","authenticated-orcid":true,"given":"Anu","family":"Chittenden","sequence":"additional","affiliation":[{"name":"Division of Cancer Genetics and Prevention, Dana-Farber Cancer Institute, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen G.","family":"Tso","sequence":"additional","affiliation":[{"name":"Division of Cancer Genetics and Prevention, Dana-Farber Cancer Institute, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7456-0113","authenticated-orcid":true,"given":"Sophie R.","family":"Cahill","sequence":"additional","affiliation":[{"name":"Division of Cancer Genetics and Prevention, Dana-Farber Cancer Institute, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4798-1365","authenticated-orcid":true,"given":"Ryan M.","family":"Buehler","sequence":"additional","affiliation":[{"name":"Division of Cancer Genetics and Prevention, Dana-Farber Cancer Institute, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey K.","family":"D'Atri","sequence":"additional","affiliation":[{"name":"Division of Cancer Genetics and Prevention, Dana-Farber Cancer Institute, Boston, MA"},{"name":"Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9449-3982","authenticated-orcid":true,"given":"Judy E.","family":"Garber","sequence":"additional","affiliation":[{"name":"Division of Cancer Genetics and Prevention, Dana-Farber Cancer Institute, Boston, MA"},{"name":"Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA"},{"name":"Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1598-6752","authenticated-orcid":true,"given":"Huma Q.","family":"Rana","sequence":"additional","affiliation":[{"name":"Division of Cancer Genetics and Prevention, Dana-Farber Cancer Institute, Boston, MA"},{"name":"Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA"},{"name":"Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1237"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706450"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2021.0001"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/EDBK_280607"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.76.2369"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.02.011"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2019.04.013"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.24480"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2014.68"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-005-4065-z"},{"key":"e_1_3_7_12_2","article-title":"Pretest genetic education video versus genetic counseling for men considering prostate cancer germline testing: A patient-choice study to address urgent practice needs","author":"Russo J","unstructured":"Russo J, McDougall C, Bowler N, et al: Pretest genetic education video versus genetic counseling for men considering prostate cancer germline testing: A patient-choice study to address urgent practice needs. JCO Precis Oncol 10.1200\/PO.21.00238","journal-title":"JCO Precis Oncol"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2016.07.094"},{"key":"e_1_3_7_14_2","article-title":"Using a Chatbot to assess hereditary cancer risk","author":"Welch BM","unstructured":"Welch BM, Allen CG, Ritchie JB, et al: Using a Chatbot to assess hereditary cancer risk. JCO Clin Cancer Inform 10.1200\/CCI.20.00014","journal-title":"JCO Clin Cancer Inform"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1200\/OP.23.00007"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1200\/OP-24-00809"},{"key":"e_1_3_7_17_2","unstructured":"Stopfer JE Garber JE Rana HQ. DFCI Genetic Testing Video [video]. 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