{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:58:59Z","timestamp":1791413939679,"version":"4.3.3"},"reference-count":21,"publisher":"American Society of Clinical Oncology (ASCO)","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Oncol Pract"],"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>The National Comprehensive Cancer Network recommends germline genetic testing for patients with prostate cancer and high-risk features or a suggestive family history. In 2024, the University of Colorado Urological Oncology Multidisciplinary Clinic (MDC) transitioned from a referral-based to a mainstream genetic testing model to streamline access and improve completion rates. We report the impact of this implementation on genetic testing uptake and subsequent genetic counseling recommendations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The impact of a quality improvement initiative implemented in 2024 was assessed by comparing patients with prostate cancer evaluated at the urologic oncology MDC in consecutive years. In 2024, patients seen in MDC who met criteria for genetic testing were offered testing with a mainstream genetic testing model. These patients were then compared with eligible patients who were seen in 2023 when a traditional referral-based testing model was used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      A total of 432 patients were evaluated (190 in 2023, 242 in 2024). Of those, 112 patients in 2023 and 115 patients in 2024 met eligibility criteria. Completion of genetic testing increased significantly from 30% (34\/112) in 2023 to 72% (83\/115) in 2024 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001). Among patients tested with the mainstream model in 2024, pathogenic variants were identified in 10 (12%) individuals. Seven of 10 patients with pathogenic variants completed post-test genetic counseling, where cascade testing and preventive screening recommendations were discussed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Transitioning to a provider-initiated, mainstream genetic testing model significantly improved pretest genetic testing completion rates within a multidisciplinary prostate cancer clinic. This integrated approach enhanced care coordination and expedited genetic evaluation, potentially representing a scalable framework to expand precision oncology and hereditary cancer risk assessment in prostate cancer management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/op-25-01428","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T19:59:06Z","timestamp":1779998346000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Improving Genetic Testing Uptake in Prostate Cancer: Outcomes From a Multidisciplinary Clinic Evaluation"],"prefix":"10.1200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4371-572X","authenticated-orcid":true,"given":"Laura S.","family":"Graham","sequence":"first","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine, University of Colorado Anschutz Medical Center, Aurora, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0473-4058","authenticated-orcid":true,"given":"Aditya","family":"Mantha","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Colorado, Aurora, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0524-2810","authenticated-orcid":true,"given":"Chiagozie","family":"Paul-Onyia","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Colorado, Aurora, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Ku","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine, University of Colorado Anschutz Medical Center, Aurora, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breana","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery, University of Colorado Anschutz Medical Center, Aurora, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6053-7200","authenticated-orcid":true,"given":"Marie E.","family":"Wood","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Internal Medicine, University of Colorado Anschutz Medical Center, Aurora, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"e_1_3_5_2_2","volume-title":"Prostate Cancer, StatPearls","author":"Leslie SW","year":"2025","unstructured":"Leslie SW, Soon-Sutton TL, Skelton WP: Prostate Cancer, StatPearls. Treasure Island (FL), StatPearls Publishing LLC, 2025"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.811044"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-022-02136-3"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S16747"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200007133430201"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.17703"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.315739.118"},{"key":"e_1_3_5_9_2","volume-title":"Board PDQCGE: Genetics of Prostate Cancer (PDQ\u00ae): Health Professional Version, PDQ Cancer Information Summaries","year":"2002","unstructured":"Board PDQCGE: Genetics of Prostate Cancer (PDQ\u00ae): Health Professional Version, PDQ Cancer Information Summaries. Bethesda (MD), National Cancer Institute (US), 2002"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1603144"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-1683(20)36211-X"},{"key":"e_1_3_5_12_2","unstructured":"Cheng HH Giri VN Goggins M et al: Genetic\/familial high-risk assessment: Breast ovarian pancreatic and prostate (version 2.2026): Featured updates to the NCCN guidelines. Huntington NY: Harborside Press. J Natl Compr Canc Netw 24:9 2025"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","unstructured":"Carlo MI Giri VN Paller CJ et al: Evolving intersection between inherited cancer genetics and therapeutic clinical trials in prostate cancer: A white paper from the Germline Genetics Working Group of the prostate cancer clinical trials consortium. JCO Precis Oncol 10.1200\/PO.18.00060","DOI":"10.1200\/PO.18.00060"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.01035"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-023-00676-0"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.08.019"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000001404"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/jgc4.1947"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13053-022-00213-5"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctarc.2022.100588"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1200\/OP.22.00634"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2023.3748"}],"container-title":["JCO Oncology Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/OP-25-01428","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T19:59:09Z","timestamp":1780430349000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/OP-25-01428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,28]]},"references-count":21,"alternative-id":["10.1200\/OP-25-01428"],"URL":"https:\/\/doi.org\/10.1200\/op-25-01428","relation":{},"ISSN":["2688-1527","2688-1535"],"issn-type":[{"value":"2688-1527","type":"print"},{"value":"2688-1535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,28]]},"assertion":[{"value":"2025-12-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-06","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"OP-25-01428"}}