{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T20:24:20Z","timestamp":1787603060609,"version":"build-2736575974"},"reference-count":22,"publisher":"American Society of Clinical Oncology (ASCO)","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Oncol Pract"],"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>\n                      Racial disparities in prostate cancer clinical trial participation persist. Sociodemographic and psychosocial predictors of willingness to discuss trials are often studied in separate models that do not account for intercorrelations. Using consent-time data from the Partnering Around Cancer Clinical Trials (PACCT) study (ClinicalTrials.gov identifier:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT02906241\">NCT02906241<\/jats:ext-link>\n                      ), we examined multidimensional group-based medical mistrust (GBMM) and related factors within one structural equation model (SEM).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We conducted a cross-sectional secondary analysis of patient-reported data at consent from 286 Black and White men with prostate cancer enrolled in PACCT phases I and II (November 2016-February 2021) at two National Cancer Institute-designated centers. Willingness and general trust in physicians were observed variables; GBMM was a latent construct (suspicion, disparities, lack of support subscales). Models used robust maximum likelihood in lavaan (239 of 286 with complete SEM data).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Higher GBMM (\u03b2 = \u2212.247;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .028) and older age (\u03b2 = \u2212.217;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .004) were associated with lower willingness; higher education (\u03b2 = .176;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .019) was associated with higher willingness. Black (\n                      <jats:italic toggle=\"yes\">v<\/jats:italic>\n                      White) race was associated with higher GBMM (\u03b2 = .555;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001) and had a significant indirect association with willingness through GBMM (\u03b2 = \u2212.137;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .035), not a significant direct path. Higher income was associated with greater GBMM (\u03b2 = .221;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .020) and lower physician trust (\u03b2 = \u2212.268;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .002) but not with willingness.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Willingness to discuss trials reflected an interconnected pattern in which multidimensional GBMM was central. Findings are exploratory and associational and support patient-centered trial communication where mistrust may be salient, tailored discussions for older patients, and accessible information where comprehension needs may apply. Longitudinal evaluation of PACCT interventions is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/op-26-00036","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T19:59:09Z","timestamp":1787601549000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Interconnectedness of Factors Affecting Patient Willingness to Discuss Prostate Cancer Clinical Trials With Physicians"],"prefix":"10.1200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9882-0362","authenticated-orcid":true,"given":"Janaka S.S.","family":"Liyanage","sequence":"first","affiliation":[{"name":"Biostatistics and Bioinformatics Core, Karmanos Cancer Institute, Detroit, MI"},{"name":"Department of Oncology, Wayne State University School of Medicine, Detroit, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4850-5054","authenticated-orcid":true,"given":"Vy","family":"Ong","sequence":"additional","affiliation":[{"name":"Biostatistics and Bioinformatics Core, Karmanos Cancer Institute, Detroit, MI"},{"name":"Department of Oncology, Wayne State University School of Medicine, Detroit, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8910-7079","authenticated-orcid":true,"given":"Lauren M.","family":"Hamel","sequence":"additional","affiliation":[{"name":"Department of Oncology, Wayne State University School of Medicine, Detroit, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8137-6098","authenticated-orcid":true,"given":"Susan","family":"Eggly","sequence":"additional","affiliation":[{"name":"Department of Oncology, Wayne State University School of Medicine, Detroit, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7908-1215","authenticated-orcid":true,"given":"Michael A.","family":"Carducci","sequence":"additional","affiliation":[{"name":"The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4935-8786","authenticated-orcid":true,"given":"Dina G.","family":"Lansey","sequence":"additional","affiliation":[{"name":"The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1381-2713","authenticated-orcid":true,"given":"Elisabeth I.","family":"Heath","sequence":"additional","affiliation":[{"name":"Department of Oncology, Wayne State University School of Medicine, Detroit, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0232-348X","authenticated-orcid":true,"given":"Tanina F.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Oncology, Wayne State University School of Medicine, Detroit, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8907-6751","authenticated-orcid":true,"given":"Terrance L.","family":"Albrecht","sequence":"additional","affiliation":[{"name":"Department of Oncology, Wayne State University School of Medicine, Detroit, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Manning","sequence":"additional","affiliation":[{"name":"Department of Psychology, Oakland University, Rochester, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1120-073X","authenticated-orcid":true,"given":"Seongho","family":"Kim","sequence":"additional","affiliation":[{"name":"Biostatistics and Bioinformatics Core, Karmanos Cancer Institute, Detroit, MI"},{"name":"Department of Oncology, Wayne State University School of Medicine, Detroit, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol31090396"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","unstructured":"McKay RR Gold T Zarif JC et al: Tackling diversity in prostate cancer clinical trials: A report from the Diversity Working Group of the IRONMAN Registry. 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