{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:58:07Z","timestamp":1790629087295,"version":"4.1.0"},"reference-count":70,"publisher":"American Society of Clinical Oncology (ASCO)","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Oncol Pract"],"abstract":"<jats:sec>\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Cardiovascular disease (CVD) is a leading noncancer cause of death among patients with prostate cancer (PC). Population-based risk calculators do not account for treatment-related effects of androgen-deprivation therapy (ADT) and androgen receptor pathway inhibitors (ARPis), and they have not been validated across PC treatment states.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Observations<\/jats:title>\n                    <jats:p>This Prostate Cancer Foundation\u2013sponsored clinician-industry consensus and narrative review proposes a pragmatic identification and triage schema for point-of-care use. The schema supports rapid risk capture, tier assignment, and referral or risk-factor optimization triggers; it does not provide cardiovascular therapeutic algorithms. We synthesize evidence on baseline cardiometabolic burden, ADT-associated adiposity and muscle-strength changes, plaque progression, ARPi-associated hypertension and cardiac events, suboptimal real-world risk-factor control, and social-needs barriers. Patients are classified as high risk when they have prior major cardiovascular events or established clinical atherosclerotic CVD; intermediate risk when they have no prior event but at least two uncontrolled or adverse risk factors; and low risk when neither criterion is met. We clarify cutpoints, the rationale for operational thresholding, essential versus optional intake elements, and capacity-sensitive referral pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Relevance<\/jats:title>\n                    <jats:p>The proposed three-tier schema should be viewed as a hypothesis-generating checklist for oncology, urology, radiation oncology, primary care, and cardiovascular teams. Prospective validation, workflow testing, calibration of referral thresholds, and inclusion of patient and clinic-staff stakeholders are required before broad implementation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/op-26-00312","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:59:08Z","timestamp":1790625548000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Cardiovascular Risk Triage Schema for Patients With Prostate Cancer Treated With Hormone Therapy"],"prefix":"10.1200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0253-1174","authenticated-orcid":true,"given":"Avirup","family":"Guha","sequence":"first","affiliation":[{"name":"Georgia Cancer Center, Medical College of Georgia at Augusta University, Augusta, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9935-8904","authenticated-orcid":true,"given":"Ana","family":"Barac","sequence":"additional","affiliation":[{"name":"Inova Schar Heart and Vascular Institute and Inova Schar Cancer Institute, Inova Health System, Fairfax, VA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael James","family":"Ryan","sequence":"additional","affiliation":[{"name":"Pfizer Inc, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randala","family":"Hamdan","sequence":"additional","affiliation":[{"name":"Pfizer Inc, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geeta","family":"Devgan","sequence":"additional","affiliation":[{"name":"Pfizer Inc, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2653-4110","authenticated-orcid":true,"given":"Catherine H.","family":"Marshall","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5746-6555","authenticated-orcid":true,"given":"Silke","family":"Gillessen","sequence":"additional","affiliation":[{"name":"Oncology Institute of Southern Switzerland, EOC, Bellinzona and Universit\u00e0 della Svizzera Italiana, Lugano, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3933-9207","authenticated-orcid":true,"given":"Stacy","family":"Loeb","sequence":"additional","affiliation":[{"name":"Department of Urology and Population Health, New York University Langone Health and Manhattan Veterans Affairs, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0581-7963","authenticated-orcid":true,"given":"Rana R.","family":"McKay","sequence":"additional","affiliation":[{"name":"Moores Cancer Center, University of California San Diego, La Jolla, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0031-9655","authenticated-orcid":true,"given":"Emmanuel S.","family":"Antonarakis","sequence":"additional","affiliation":[{"name":"University of Minnesota Masonic Cancer Center, Minneapolis, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7392-8916","authenticated-orcid":true,"given":"Zachary","family":"Klaassen","sequence":"additional","affiliation":[{"name":"Department of Urology, Medical College of Georgia at Augusta University (Wellstar MCG Health), Augusta, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenakshi","family":"Davuluri","sequence":"additional","affiliation":[{"name":"Bayer HealthCare Pharmaceuticals Inc, Whippany, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0206-3895","authenticated-orcid":true,"given":"Alan H.","family":"Bryce","sequence":"additional","affiliation":[{"name":"City of Hope Cancer Center, Goodyear, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8077-4975","authenticated-orcid":true,"given":"Yun Rose","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, City of Hope, Duarte, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nader","family":"El-Chaar","sequence":"additional","affiliation":[{"name":"Astellas Pharma Global Development, Inc, Northbrook, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Braun","sequence":"additional","affiliation":[{"name":"Astellas Pharma Global Development, Inc, Northbrook, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0380-9465","authenticated-orcid":true,"given":"Maha","family":"Hussain","sequence":"additional","affiliation":[{"name":"Robert H. 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