{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:46:10Z","timestamp":1791639970732,"version":"4.3.4"},"reference-count":34,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"7","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Oncol Pract"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>Excess weight is a key modifiable risk factor for breast cancer. Glucagon-like peptide-1 receptor agonists (GLP-1) promote weight loss and improve metabolic health, but their effect on breast cancer risk remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study from January 1, 2022, to June 30, 2025, using electronic health records. We identified 217,624 unique women who underwent breast imaging; restricting to ages 45-80 years with a BMI \u226525 and a documented imaging outcome (n = 111,646; median age 61 years). The primary outcome was breast cancer detection. GLP-1 use was defined as a first prescription before the examination date and assessed in relation to race, ethnicity, age, and type 2 diabetes. To address potential confounding between these covariates and GLP-1 exposure, we performed one-to-one, case-control matching using propensity scores on the basis of age, race, ethnicity, highest BMI, breast density, and history of type 2 diabetes. The propensity matching to the GLP-1 use group was performed using the greedy nearest neighbor approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      GLP-1 exposure was associated with a lower incidence of breast cancer (odds ratio [OR], 0.649 [95% CI, 0.569 to 0.741];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .0001). In the matched logistic regression (30,528 observations; 600 cancer cases), GLP-1 exposure was associated with a lower breast cancer incidence (OR, 0.695 [95% CI, 0.590 to 0.819];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>In this large observational study of women undergoing breast imaging at a major academic center and affiliated sites, GLP-1 treatment was associated with a lower incidence of breast cancer, independent of age, race, ethnicity, BMI, breast density, and diabetes. The findings support the need for prospective trials investigating GLP-1 agonists for breast cancer prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/op-26-00485","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T12:00:14Z","timestamp":1780401614000},"page":"1341-1348","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":7,"title":["GLP-1 Agonists Are Associated With a Significant Reduction in Breast Cancer Incidence in Women"],"prefix":"10.1200","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7209-4216","authenticated-orcid":true,"given":"Elizabeth S.","family":"McDonald","sequence":"first","affiliation":[{"name":"Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura B.","family":"Gillis","sequence":"additional","affiliation":[{"name":"American College of Radiology, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3772-9669","authenticated-orcid":true,"given":"Peter E.","family":"Gabriel","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Perelman School of Medicine at the University of Pennsylvania"},{"name":"Cancer Informatics Shared Resource, Abramson Cancer Center, University of Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kham M.","family":"Xapakdy","sequence":"additional","affiliation":[{"name":"Penn Medicine, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3209-1034","authenticated-orcid":true,"given":"Anthony J.","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6646-433X","authenticated-orcid":true,"given":"Abigail G.","family":"Doucette","sequence":"additional","affiliation":[{"name":"Cancer Informatics Shared Resource, Abramson Cancer Center, University of Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell D.","family":"Schnall","sequence":"additional","affiliation":[{"name":"Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9723-3876","authenticated-orcid":true,"given":"John B.","family":"Buse","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0529-7654","authenticated-orcid":true,"given":"Etta D.","family":"Pisano","sequence":"additional","affiliation":[{"name":"Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA"},{"name":"American College of Radiology, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu042"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-019-0787-1"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpt.2023.03.002"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.14694\/EdBook_AM.2013.33.52"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.3520"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.1771"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-018-1056-1"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj494"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.1095"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2017.10.010"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-26-0018"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076192"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.24945"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2024.04.041"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-025-01110-1"},{"key":"e_1_3_6_17_2","first-page":"258","article-title":"The benefits of GLP-1 drugs beyond obesity","volume":"385","author":"Drucker DJ","year":"2024","unstructured":"Drucker DJ: The benefits of GLP-1 drugs beyond obesity. 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