{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:09:20Z","timestamp":1789416560997,"version":"build-2803163510"},"reference-count":33,"publisher":"American Society of Clinical Oncology (ASCO)","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Oncol Pract"],"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>Multicancer detection (MCD) tests aim to detect different cancer types using a single test. However, evidence on their potential for screening asymptomatic populations remains limited. We consolidated evidence from prospective cohort studies evaluating blood-based MCD tests in primarily asymptomatic adults to contextualize upcoming randomized controlled trial results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIALS AND METHODS<\/jats:title>\n                    <jats:p>We updated and extended a prior review (to September 2023), conducting comprehensive Medline\/Embase searches to February 1, 2026. Key outcomes included cancers detected and not detected by MCD tests, false-positive MCD tests, and diagnostic investigation pathways. Risk of bias (RoB) was assessed using a modified Quality Assessment of Diagnostic Accuracy Studies-2 tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>From 2,723 screened records (244 previously shortlisted to 2023, 2,479 records for 2023-2026), we included 18 articles (12 studies, nine MCD tests); of these, 11 articles had not appeared in prior reviews. Cancer detection rates varied widely between studies, for example, new MCD\u2013test\u2013detected invasive cancers diagnosed \u226412 months post-test ranging from 18.8 (95% CI, 11.0 to 30.1) to 43.8 (95% CI, 29.4 to 62.8) per 10,000 tested, with MCD\u2013test\u2013detected invasive stage I to II cancers ranging from 9.0 (95% CI, 4.2 to 17.2) to 21.0 (95% CI, 11.6 to 35.5) per 10,000 tested. False-positives exceeded MCD\u2013test\u2013detected cancers (eg, approximately 1.6-fold in PATHFINDER, 1.5-fold K-DETEK, 4.2-fold DETECT-A, 8.1-fold SeekInCare studies). Diagnostic investigation pathways were prespecified\/suggested in four of eight interventional studies. Where reported, the median time to diagnostic resolution varied from &lt;0.1 months to 4 months for MCD\u2013test\u2013detected cancers, with substantially higher 75th percentiles (3.1-7 months), and similar patterns were observed for false-positive MCD tests. No study was judged to have overall low RoB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Substantial heterogeneity in cancer yield metrics likely reflects differences in MCD technologies, diagnostic pathways, follow-up duration, and background standard-of-care screening. Long-term follow-up, randomized trials, fully-paired test comparisons, and implementation research are essential to determine the potential of MCD tests for population screening.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/op-26-00570","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T19:59:06Z","timestamp":1789415946000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Multicancer Detection Tests for Population-Wide Screening of Asymptomatic Individuals: A Systematic Review"],"prefix":"10.1200","author":[{"given":"Suzanne","family":"Hughes","sequence":"first","affiliation":[{"name":"The Daffodil Centre, The University of Sydney, and Cancer Council NSW, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2244-1486","authenticated-orcid":true,"given":"Priscilla","family":"Chan","sequence":"additional","affiliation":[{"name":"The Daffodil Centre, The University of Sydney, and Cancer Council NSW, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea","family":"Carle Harrison","sequence":"additional","affiliation":[{"name":"The Daffodil Centre, The University of Sydney, and Cancer Council NSW, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Yuill","sequence":"additional","affiliation":[{"name":"The Daffodil Centre, The University of Sydney, and Cancer Council NSW, Sydney, New South Wales, Australia"},{"name":"The Cancer Elimination Collaboration, The University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Barron","sequence":"additional","affiliation":[{"name":"The Daffodil Centre, The University of Sydney, and Cancer Council NSW, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8902-6869","authenticated-orcid":true,"given":"Qingwei","family":"Luo","sequence":"additional","affiliation":[{"name":"The Daffodil Centre, The University of Sydney, and Cancer Council NSW, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4796-6852","authenticated-orcid":true,"given":"Sibel","family":"Saya","sequence":"additional","affiliation":[{"name":"Department of General Practice &amp; Primary Care, University of Melbourne, Melbourne, Victoria, Australia"},{"name":"Collaborative Centre for Cancer Genomic Medicine, University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2493-9974","authenticated-orcid":true,"given":"Javiera","family":"Martinez-Gutierrez","sequence":"additional","affiliation":[{"name":"Department of General Practice &amp; Primary Care, University of Melbourne, Melbourne, Victoria, Australia"},{"name":"Collaborative Centre for Cancer Genomic Medicine, University of Melbourne, Melbourne, Victoria, Australia"},{"name":"Department of Family Medicine, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1509-8744","authenticated-orcid":true,"given":"Peter","family":"Sasieni","sequence":"additional","affiliation":[{"name":"Wolfson Institute of Population Health, Queen Mary University of London, London, England"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0280-0883","authenticated-orcid":true,"given":"Natalie","family":"Taylor","sequence":"additional","affiliation":[{"name":"Implementation to Impact (i2i), School of Population Health, University of New South Wales, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6443-6618","authenticated-orcid":true,"given":"Karen","family":"Canfell","sequence":"additional","affiliation":[{"name":"The Cancer Elimination Collaboration, The University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5274-6336","authenticated-orcid":false,"given":"Jon","family":"Emery","sequence":"additional","affiliation":[{"name":"Department of General Practice &amp; Primary Care, University of Melbourne, Melbourne, Victoria, Australia"},{"name":"Collaborative Centre for Cancer Genomic Medicine, University of Melbourne, Melbourne, Victoria, Australia"},{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3641-952X","authenticated-orcid":true,"given":"Nehmat","family":"Houssami","sequence":"additional","affiliation":[{"name":"The Daffodil Centre, The University of Sydney, and Cancer Council NSW, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0585-2312","authenticated-orcid":true,"given":"Julia","family":"Steinberg","sequence":"additional","affiliation":[{"name":"The Daffodil Centre, The University of Sydney, and Cancer Council NSW, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of MCD Spotlight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpo.2026.100708"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/18758592241308754"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(22)00090-1"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-025-01033-x"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.3310\/DLMT1294"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.7326\/ANNALS-25-01877"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14194818"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-8-201110180-00009"},{"key":"e_1_3_8_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb9601"},{"key":"e_1_3_8_11_2","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-23-0451"},{"key":"e_1_3_8_12_2","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-24-0107"},{"key":"e_1_3_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01700-2"},{"key":"e_1_3_8_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13143501"},{"key":"e_1_3_8_15_2","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-24-0468"},{"key":"e_1_3_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(24)00645-4"},{"key":"e_1_3_8_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2024.1860"},{"key":"e_1_3_8_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/21501319251329290"},{"key":"e_1_3_8_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-64094-7"},{"key":"e_1_3_8_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-025-03929-y"},{"key":"e_1_3_8_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/20565623.2024.2395244"},{"key":"e_1_3_8_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2025.04.001"},{"key":"e_1_3_8_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-50304-y"},{"key":"e_1_3_8_24_2","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-20-0322"},{"key":"e_1_3_8_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/14737159.2021.2013201"},{"key":"e_1_3_8_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-025-03735-2"},{"key":"e_1_3_8_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.35709"},{"key":"e_1_3_8_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2025.103733"},{"key":"e_1_3_8_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2022.03.006"},{"key":"e_1_3_8_30_2","volume-title":"GRAIL PATHFINDER 2 Results Show Galleri\u00ae Multi-Cancer Early Detection Blood Test Increased Cancer Detection More than Seven-fold when Added to USPSTF A and B Recommended Screenings","author":"GRAIL","year":"2025","unstructured":"GRAIL: GRAIL PATHFINDER 2 Results Show Galleri\u00ae Multi-Cancer Early Detection Blood Test Increased Cancer Detection More than Seven-fold when Added to USPSTF A and B Recommended Screenings. 2025. https:\/\/grail.com\/press-releases\/grail-pathfinder-2-results-show-galleri-multi-cancer-early-detection-blood-test-increased-cancer-detection-more-than-seven-fold-when-added-to-uspstf-a-and-b-recommended-screenings\/"},{"key":"e_1_3_8_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djag001"},{"key":"e_1_3_8_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/93.14.1054"},{"key":"e_1_3_8_33_2","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X251351639"},{"key":"e_1_3_8_34_2","article-title":"Prognostic significance of blood-based multicancer detection in circulating tumor DNA: Five-year outcomes analysis","author":"Swanton C","unstructured":"Swanton C, Bryce A, Cohn AL, et al: Prognostic significance of blood-based multicancer detection in circulating tumor DNA: Five-year outcomes analysis. JCO Precis Oncol 10.1200\/PO-25-00725","journal-title":"JCO Precis Oncol"}],"container-title":["JCO Oncology Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/OP-26-00570","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T19:59:08Z","timestamp":1789415948000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/OP-26-00570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,14]]},"references-count":33,"alternative-id":["10.1200\/OP-26-00570"],"URL":"https:\/\/doi.org\/10.1200\/op-26-00570","relation":{},"ISSN":["2688-1527","2688-1535"],"issn-type":[{"value":"2688-1527","type":"print"},{"value":"2688-1535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,14]]},"assertion":[{"value":"2026-05-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-30","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"OP-26-00570"}}