{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:22:26Z","timestamp":1780392146145,"version":"3.54.1"},"reference-count":32,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"7","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Oncology Practice"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec><jats:title>PURPOSE:<\/jats:title><jats:p> This study assessed the long-term quality of life (QOL) of patients with aggressive lymphoma subtypes treated with autologous hematopoietic cell transplant (autoHCT) compared with those without history of transplant. <\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS:<\/jats:title><jats:p> Patient-reported QOL measures were prospectively gathered from patients enrolled in the Iowa\/Mayo Specialized Program of Research Excellence Molecular Epidemiology Resource cohort with aggressive lymphoma subtypes. QOL was measured using the Functional Assessment of Cancer Therapy-General (FACT-G), Functional Assessment of Chronic Illness Therapy\u2013Fatigue Scale, State-Trait Anxiety Inventory (STAI), and Profile of Mood States instruments and with a numeric rating scale for overall QOL and spiritual QOL. The autoHCT group and no HCT groups were compared at 3 years (FU3) and 6 years (FU6) after lymphoma diagnosis. <\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p> In total, 980 patients with lymphoma (106 autoHCT and 874 no HCT) diagnosed between 2002 and 2013 were included for analysis. The mean FACT-G total score was similar in the autoHCT and no HCT groups at FU3 (89.9 v 90.1, P = .64) and also at FU6 (91.5 v 89.6, P = .44). No differences between the autoHCT and no HCT groups were identified in the FACT subscales. The STAI identified lower anxiety in the autoHCT group by mean STAI1 (state) at FU3 (30.1 v 33.4, P &lt; .01) and by mean STAI2 (trait) at FU6 (30.1 v 33.5, P = .02). No other clinically meaningful differences were identified between the two groups using the other QOL instruments. <\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION:<\/jats:title><jats:p> Patients remaining in remission at 3 and 6 years after diagnosis had a high level of QOL with no significant differences associated with history of treatment with autoHCT. <\/jats:p><\/jats:sec>","DOI":"10.1200\/op.21.00694","type":"journal-article","created":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T19:59:17Z","timestamp":1653076757000},"page":"e1069-e1080","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":3,"title":["Long-Term Health-Related Quality of Life of Autologous Hematopoietic Cell Transplantation Patients and Nontransplant Patients With Aggressive Lymphoma: A Prospective Cohort Analysis"],"prefix":"10.1200","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4964-167X","authenticated-orcid":false,"given":"Christopher S.","family":"Strouse","sequence":"first","affiliation":[{"name":"Division of Hematology, Oncology, and Blood and Marrow Transplantation, University of Iowa, Iowa City, IA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa C.","family":"Larson","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawna L.","family":"Ehlers","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9641-5627","authenticated-orcid":false,"given":"Kathleen J.","family":"Yost","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1867-0526","authenticated-orcid":false,"given":"Matthew J.","family":"Maurer","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1244-6758","authenticated-orcid":false,"given":"Stephen M.","family":"Ansell","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Inwards","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick B.","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4675-4903","authenticated-orcid":false,"given":"Ivana N.","family":"Micallef","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5084-0698","authenticated-orcid":false,"given":"Brian K.","family":"Link","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology, and Blood and Marrow Transplantation, University of Iowa, Iowa City, IA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7891-9891","authenticated-orcid":false,"given":"Umar","family":"Farooq","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology, and Blood and Marrow Transplantation, University of Iowa, Iowa City, IA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7482-178X","authenticated-orcid":false,"given":"James R.","family":"Cerhan","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4518-2309","authenticated-orcid":false,"given":"Carrie A.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"b1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08938-9"},{"key":"b2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2010.07.008"},{"key":"b3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-06-225631"},{"key":"b4","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704561"},{"key":"b5","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.304"},{"key":"b6","doi-asserted-by":"publisher","DOI":"10.1188\/04.ONF.937-944"},{"key":"b7","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705664"},{"key":"b8","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.40.6249"},{"key":"b9","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13104"},{"key":"b10","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2011.613132"},{"key":"b11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2005.00438.x"},{"key":"b12","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyx119"},{"key":"b13","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.3.570"},{"key":"b14","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.711830"},{"key":"b15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2007.01.016"},{"key":"b16","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.7670"},{"key":"b17","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-014-0187-z"},{"key":"b18","volume-title":"Manual for the State-Trait Anxiety Inventory","author":"Spielberger C","year":"1983"},{"key":"b19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1758-0854.2009.01017.x"},{"key":"b20","doi-asserted-by":"publisher","DOI":"10.1207\/s15327752jpa4703_14"},{"key":"b21","doi-asserted-by":"publisher","DOI":"10.1002\/pon.564"},{"key":"b22","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2016.05.013"},{"key":"b23","doi-asserted-by":"publisher","DOI":"10.1586\/erp.11.9"},{"key":"b24","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2522"},{"key":"b25","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/aft078"},{"key":"b26","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-013-1980-1"},{"key":"b27","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(98)00136-1"},{"key":"b28","doi-asserted-by":"publisher","DOI":"10.3109\/10428191003587263"},{"key":"b29","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19991101)86:9<1768::AID-CNCR19>3.0.CO;2-O"},{"key":"b30","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2010.513749"},{"key":"b31","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2019.09.007"},{"key":"b32","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.57.6801"}],"container-title":["JCO Oncology Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/OP.21.00694","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T22:01:40Z","timestamp":1657663300000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/OP.21.00694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1200\/OP.21.00694"],"URL":"https:\/\/doi.org\/10.1200\/op.21.00694","relation":{},"ISSN":["2688-1527","2688-1535"],"issn-type":[{"value":"2688-1527","type":"print"},{"value":"2688-1535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"2021-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-11","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}