{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T17:58:58Z","timestamp":1780509538406,"version":"3.54.1"},"reference-count":92,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"3","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Oncol Pract"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:p>Classic Hodgkin lymphoma (cHL) is highly curable at all stages. Research efforts over the past few decades have largely focused on interim PET-adapted strategies for therapy de-escalation or intensification. The overarching goals have been to increase cure rates, minimize potential therapy-related effects, and optimize survivorship. Better understanding of the biology of cHL has led to the development and approval of effective novel agents including the antibody-drug conjugate brentuximab vedotin and the checkpoint inhibitor immunotherapies. In this review, we discuss recent trial results and how these agents are integrated into clinical practice with the goal of further optimizing outcomes.<\/jats:p>","DOI":"10.1200\/op.24.00277","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T20:01:16Z","timestamp":1726171276000},"page":"300-312","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":4,"title":["Integrating Novel Agents Into the Clinical Management of Classic Hodgkin Lymphoma"],"prefix":"10.1200","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4128-2537","authenticated-orcid":true,"given":"Joseph G.","family":"Schroers-Martin","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Oncology, Stanford University Medical Center, Stanford, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3219-2292","authenticated-orcid":true,"given":"Ranjana","family":"Advani","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Oncology, Stanford University Medical Center, Stanford, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1510093"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2022.0021"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy080"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-02-699850"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-07-861641"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206125"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-282780"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.77.3994"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022019386"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023010334"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408648"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.00964"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.68.6394"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022008420"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.01281"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.00108"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.02355"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2022-156382"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.HS9.0000890668.27643.97"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32134-7"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.75.2543"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000719"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30784-8"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-021-04460-9"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(21)00101-0"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.01777"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(21)00102-2"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01315-1"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022008116"},{"key":"e_1_3_5_31_2","first-page":"2576","article-title":"Concurrent pembrolizumab with AVD for untreated classic Hodgkin lymphoma","volume":"141","author":"Lynch RC","year":"2023","unstructured":"Lynch RC, Ujjani CS, Poh C, et al: Concurrent pembrolizumab with AVD for untreated classic Hodgkin lymphoma. Blood 141:2576-2586, 2023","journal-title":"Blood"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.00315"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2023.41.17_suppl.LBA4"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30696-4"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-021-01386-z"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020007400"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-05-718528"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06903-x"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.63.0699"},{"key":"e_1_3_5_40_2","first-page":"1369","article-title":"Hodgkin lymphoma in older patients: An uncommon disease in need of study","volume":"22","author":"Evens AM","year":"2008","unstructured":"Evens AM, Sweetenham JW, Horning SJ: Hodgkin lymphoma in older patients: An uncommon disease in need of study. Oncology 22:1369-1379, 2008","journal-title":"Oncology"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13419"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1708984"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.79.0139"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-180114"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-06-644336"},{"key":"e_1_3_5_46_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-06-787200"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(20)30275-1"},{"key":"e_1_3_5_48_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022019536"},{"key":"e_1_3_5_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08938-9"},{"key":"e_1_3_5_50_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-10-388058"},{"key":"e_1_3_5_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2015.07.018"},{"key":"e_1_3_5_52_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V126.23.519.519"},{"key":"e_1_3_5_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)70013-6"},{"key":"e_1_3_5_54_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16499"},{"key":"e_1_3_5_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(21)00170-8"},{"key":"e_1_3_5_56_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-99-112235"},{"key":"e_1_3_5_57_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz009"},{"key":"e_1_3_5_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00005-X"},{"key":"e_1_3_5_59_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.01056"},{"key":"e_1_3_5_60_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2022.7975"},{"key":"e_1_3_5_61_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015423"},{"key":"e_1_3_5_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(20)30221-0"},{"key":"e_1_3_5_63_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-184531"},{"key":"e_1_3_5_64_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020009178"},{"key":"e_1_3_5_65_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26827"},{"key":"e_1_3_5_66_2","first-page":"2727","article-title":"Improved outcomes for relapsed\/refractory Hodgkin lymphoma after autologous transplantation in the era of novel agents","volume":"141","author":"Spinner MA","year":"2023","unstructured":"Spinner MA, Sica RA, Tamaresis JS, et al: Improved outcomes for relapsed\/refractory Hodgkin lymphoma after autologous transplantation in the era of novel agents. Blood 141:2727-2737, 2023","journal-title":"Blood"},{"key":"e_1_3_5_67_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2020-0167"},{"key":"e_1_3_5_68_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V122.21.2099.2099"},{"key":"e_1_3_5_69_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.243238"},{"key":"e_1_3_5_70_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-11-815183"},{"key":"e_1_3_5_71_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.HS9.0000890964.54059.2c"},{"key":"e_1_3_5_72_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2013.798868"},{"key":"e_1_3_5_73_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2021.279564"},{"key":"e_1_3_5_74_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-022-05011-6"},{"key":"e_1_3_5_75_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000215"},{"key":"e_1_3_5_76_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2021-148139"},{"key":"e_1_3_5_77_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2020-136384"},{"key":"e_1_3_5_78_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8722-7-24"},{"key":"e_1_3_5_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(18)30192-3"},{"key":"e_1_3_5_80_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-1680"},{"key":"e_1_3_5_81_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021004511"},{"key":"e_1_3_5_82_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.02151"},{"key":"e_1_3_5_83_2","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-002347"},{"key":"e_1_3_5_84_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023020485"},{"key":"e_1_3_5_85_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.HS9.0000971180.14196.30"},{"key":"e_1_3_5_86_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2022.40.16_suppl.7545"},{"key":"e_1_3_5_87_2","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.AM2023-CT265"},{"key":"e_1_3_5_88_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-03-770719"},{"key":"e_1_3_5_89_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0905680"},{"key":"e_1_3_5_90_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI94306"},{"key":"e_1_3_5_91_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.01342"},{"key":"e_1_3_5_92_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019004701"},{"key":"e_1_3_5_93_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-172980"}],"container-title":["JCO Oncology Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/OP.24.00277","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T21:59:45Z","timestamp":1741903185000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/OP.24.00277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":92,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1200\/OP.24.00277"],"URL":"https:\/\/doi.org\/10.1200\/op.24.00277","relation":{},"ISSN":["2688-1527","2688-1535"],"issn-type":[{"value":"2688-1527","type":"print"},{"value":"2688-1535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-03-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-11","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}