{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T13:14:05Z","timestamp":1785503645807,"version":"3.56.0"},"reference-count":40,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"9","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Precis Oncol"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n            <jats:title>PURPOSE<\/jats:title>\n            <jats:p>Pancreatic acinar cell carcinoma (PACC) is a rare and aggressive form of pancreatic cancer that originates in the acinar cells of the exocrine pancreas. In this study, we aimed to investigate the clinical and molecular characteristics of patients with PACC at our institution.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS<\/jats:title>\n            <jats:p>This was a retrospective study of patients with PACC seen at Mayo Clinic between 2002 and 2023. Baseline patient characteristics, tumor pathology, treatment strategies used, and survival outcomes were analyzed. Kaplan-Meier curves were estimated using newsurv macros in SAS.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>\n              The study included a total of 65 patients with PACC. The median age at diagnosis was 66 years. Almost half of the patients (48%) presented with resectable\/borderline-resectable disease (n = 28). Five-year overall survival (OS) for resectable\/borderline-resectable, locally advanced\/unresectable, and metastatic disease were 72.0%, 21.6%, and 20.9%, respectively. Somatic and germline next-generation sequencing identified numerous potentially actionable targets including homologous recombination (43% somatic, 33% germline),\n              <jats:italic>RAF<\/jats:italic>\n              alterations (29% somatic), and mismatch repair (14% somatic).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION<\/jats:title>\n            <jats:p>Our findings underscore the heterogeneity and aggressive nature of PACC. Despite the improved prognosis for patients with resectable\/borderline-resectable disease, OS remains poor, particularly for those with locally advanced or metastatic disease. The identification of actionable molecular targets in a significant proportion of patients highlights the potential for personalized therapeutic approaches. Future research should focus on tailored treatment strategies to exploit these molecular vulnerabilities, which may offer new options for improving outcomes in this rare malignancy.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1200\/po-24-00450","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T20:59:19Z","timestamp":1736283559000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":7,"title":["Clinical Outcomes and Molecular Profiling of Pancreatic Acinar Cell Carcinoma: A Retrospective Study"],"prefix":"10.1200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8057-0841","authenticated-orcid":true,"given":"Cody","family":"Eslinger","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology, Mayo Clinic, Phoenix, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bobak","family":"Seddighzadeh","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Mayo Clinic, Phoenix, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1601-9163","authenticated-orcid":true,"given":"Claire","family":"Yee","sequence":"additional","affiliation":[{"name":"Department of Clinical Trials and Biostatistics, Mayo Clinic, Phoenix, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5501-9282","authenticated-orcid":true,"given":"Zaid","family":"Elsabbagh","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Mayo Clinic, Phoenix, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rish","family":"Pai","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Phoenix, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2237-3102","authenticated-orcid":true,"given":"Chris","family":"Hartley","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4922-1392","authenticated-orcid":true,"given":"Jason","family":"Starr","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Mayo Clinic, Jacksonville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7721-1699","authenticated-orcid":true,"given":"Tanios","family":"Bekaii-Saab","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Mayo Clinic, Phoenix, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8460-1257","authenticated-orcid":true,"given":"Thorvardur R.","family":"Halfdanarson","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6931-242X","authenticated-orcid":true,"given":"Mohamad Bassam","family":"Sonbol","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Mayo Clinic, Phoenix, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v28.i40.5827"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2016.05.009"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00125480-200105000-00003"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.02.005"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-009-0938-z"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13236121"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000001718"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.13975"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2019-0472-RA"},{"key":"e_1_3_4_11_2","first-page":"41","article-title":"Acinar cell carcinoma of the pancreas: Overview of clinicopathologic features and insights into the molecular pathology","volume":"2","author":"La Rosa S","year":"2015","unstructured":"La Rosa S, Sessa F, Capella C: Acinar cell carcinoma of the pancreas: Overview of clinicopathologic features and insights into the molecular pathology. 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