{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T17:28:54Z","timestamp":1791739734336,"version":"4.3.4"},"reference-count":49,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"9","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Precis Oncol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n            <jats:title>PURPOSE<\/jats:title>\n            <jats:p>Cancer-related cognitive impairment (CRCI) and cancer-related fatigue (CRF) are reported by approximately 75% of patients receiving chemotherapy for breast cancer and both have been linked to inflammation. We sought to test whether an inflammation polygenic risk score (iPRS) might be associated with CRCI and\/or CRF.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS<\/jats:title>\n            <jats:p>Using data from the UK Biobank, we developed an iPRS for the INFLA-Score, a composite measure of C-reactive protein, white cell count, platelet count, and neutrophil-lymphocyte ratio. The iPRS was evaluated for association with CRCI and CRF among women with nonmetastatic breast cancer enrolled in two completed multisite clinical trials: URCC08106 and URCC10055. CRCI and CRF were measured before and after standard-of-care chemotherapy using the FACT-Cog and Multidimensional Fatigue Symptom Inventory\u2013Short Form (MFSI-SF), respectively. Linear regression evaluated the change in FACT-Cog and MFSI scores; logistic regression evaluated binary outcomes of any versus no worsening of scores. Analyses were adjusted for patient and treatment factors. We also performed exploratory genome-wide analyses.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>\n              The cohort included 802 women who received chemotherapy (anthracycline-based = 51.8%; previous surgery = 85.0%) at a median age of 55 years (range = 22-81). The iPRS was associated with a significant decrease in MFSI-SF score (\u03b2 = \u20133.29 [95% CI, \u20136.25 to \u20130.34];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              = .029) and lower odds of decreased MFSI-SF score (odds ratio, 0.66 [95% CI, 0.47 to 0.93];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              = .016) following chemotherapy. This negative relationship was partially explained by a positive correlation of the iPRS with prechemotherapy MFSI-SF score (\u03b2 = 4.33 [95% CI, 0.23 to 8.43];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              = .038). The iPRS was not associated with a change in FACT-Cog score (\u03b2 = \u20131.12;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              = .627), but single nucleotide polymorphism rs9365961 was (\u03b2 = \u201310.05;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              = 1.46 \u00d7 10\n              <jats:sup>\u22128<\/jats:sup>\n              ).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION<\/jats:title>\n            <jats:p>If validated, the iPRS could identify patients in need of supportive care interventions to reduce CRF.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1200\/po-25-00303","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T19:59:28Z","timestamp":1758052768000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":3,"title":["Association of Genetic Predisposition to Inflammation With Cancer-Related Cognitive Impairment and Fatigue in Women Who Received Chemotherapy for Nonmetastatic Breast Cancer"],"prefix":"10.1200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2278-9367","authenticated-orcid":true,"given":"Ayokunle S.","family":"Olowofela","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1735-8044","authenticated-orcid":true,"given":"Paul L.","family":"Auer","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Data Science Institute, and Cancer Center, Medical College of Wisconsin, Milwaukee, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2258-7247","authenticated-orcid":true,"given":"Michelle","family":"Janelsins","sequence":"additional","affiliation":[{"name":"Division of Supportive Care in Cancer, Department of Surgery, University of Rochester Medical Center, Rochester, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Mustian","sequence":"additional","affiliation":[{"name":"Division of Supportive Care in Cancer, Department of Surgery, University of Rochester Medical Center, Rochester, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Conlin","sequence":"additional","affiliation":[{"name":"Pacific Cancer Research Consortium (PCRC), Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9185-0606","authenticated-orcid":true,"given":"Adedayo A.","family":"Onitilo","sequence":"additional","affiliation":[{"name":"Wisconsin NCORP (WiNCORP), Weston, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Melnik","sequence":"additional","affiliation":[{"name":"Cancer Research Consortium of West Michigan (CRCWM), Grand Rapids, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Shang","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Supportive Care in Cancer, Department of Surgery, University of Rochester Medical Center, Rochester, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2303-7318","authenticated-orcid":true,"given":"Umang","family":"Gada","sequence":"additional","affiliation":[{"name":"Division of Supportive Care in Cancer, Department of Surgery, University of Rochester Medical Center, Rochester, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongying","family":"Sun","sequence":"additional","affiliation":[{"name":"Division of Supportive Care in Cancer, Department of Surgery, University of Rochester Medical Center, Rochester, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6503-0011","authenticated-orcid":true,"given":"Sarah 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