{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:04:18Z","timestamp":1783483458253,"version":"3.55.0"},"reference-count":31,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"9","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Precis Oncol"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>Cancer survivors are at risk for recurrence and second primaries, yet often lack clear guidance for long-term surveillance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We assessed the performance of a blood-based multicancer early detection (MCED) test in 1,609 survivors who participated in PATHFINDER, a prospective study of adults without current suspicion of cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Previous cancers included breast (47%), melanoma (10%), prostate (9%), colorectal (4%), and lymphoma (4%). Average time since diagnosis was 11.2 years, and a cancer signal was detected in 1.2% (20\/1,609). Ten new cancer diagnoses occurred: 5 second primaries (stage I uterine, stage II sarcoma, stage III ovarian, stage IV lymphoma, and stage IV colorectal) 8-15 years after original diagnosis and five recurrences (breast cancer) 4-11 years after original diagnosis. Test performance metrics were similar in those with and without previous cancer history.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>These findings highlight the potential of MCED tests to address a significant unmet need in long-term surveillance of survivors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/po-25-00498","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T20:57:16Z","timestamp":1766091436000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":2,"title":["Multicancer Early Detection Blood Test Performance in Cancer Survivors From the PATHFINDER Study"],"prefix":"10.1200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9128-3012","authenticated-orcid":true,"given":"Catherine R.","family":"Marinac","sequence":"first","affiliation":[{"name":"Dana-Farber Cancer Institute, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth K.","family":"O'Donnell","sequence":"additional","affiliation":[{"name":"Dana-Farber Cancer Institute, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina A.","family":"Clarke","sequence":"additional","affiliation":[{"name":"GRAIL, Inc, Menlo Park, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Lopatin","sequence":"additional","affiliation":[{"name":"GRAIL, Inc, Menlo Park, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2060-8618","authenticated-orcid":true,"given":"Eric T.","family":"Fung","sequence":"additional","affiliation":[{"name":"GRAIL, Inc, Menlo Park, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1783-0698","authenticated-orcid":true,"given":"Eric A.","family":"Klein","sequence":"additional","affiliation":[{"name":"GRAIL, Inc, Menlo Park, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_9_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djae135"},{"key":"e_1_3_9_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2017.0079"},{"key":"e_1_3_9_4_2","volume-title":"From Cancer Patient to Cancer Survivor: Lost in Transition","author":"Institute of Medicine, National Research Council","year":"2006","unstructured":"Institute of Medicine, National Research Council: From Cancer Patient to Cancer Survivor: Lost in Transition. Washington, DC, The National Academies Press, 2006. https:\/\/nap.nationalacademies.org\/catalog\/11468\/from-cancer-patient-to-cancer-survivor-lost-in-transition"},{"key":"e_1_3_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.05.806"},{"key":"e_1_3_9_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar3247"},{"key":"e_1_3_9_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007094"},{"key":"e_1_3_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01700-2"},{"key":"e_1_3_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.02.011"},{"key":"e_1_3_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2022.10.022"},{"key":"e_1_3_9_11_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-21-0417"},{"key":"e_1_3_9_12_2","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2021","unstructured":"R Core Team: R: A Language and Environment for Statistical Computing. 2021. R package version 4.1.2. https:\/\/www.R-project.org\/"},{"key":"e_1_3_9_13_2","unstructured":"US Preventive Services Task Force: A & B Recommendations. 2025. https:\/\/www.uspreventiveservicestaskforce.org\/uspstf\/recommendation-topics\/uspstf-a-and-b-recommendations"},{"key":"e_1_3_9_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-024-00568-z"},{"key":"e_1_3_9_15_2","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-24-0468"},{"key":"e_1_3_9_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.23410"},{"key":"e_1_3_9_17_2","volume-title":"NCCN Guidelines: Survivorship Version 2.2024","author":"National Comprehensive Cancer Network","year":"2024","unstructured":"National Comprehensive Cancer Network: NCCN Guidelines: Survivorship Version 2.2024. 2024. https:\/\/www.nccn.org"},{"key":"e_1_3_9_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.23130"},{"key":"e_1_3_9_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-024-07400-z"},{"key":"e_1_3_9_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/pubmed\/fdx030"},{"key":"e_1_3_9_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-013-0278-6"},{"key":"e_1_3_9_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61268-8"},{"key":"e_1_3_9_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61515-2"},{"key":"e_1_3_9_24_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.3.1080"},{"key":"e_1_3_9_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djac131"},{"key":"e_1_3_9_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61625-5"},{"key":"e_1_3_9_27_2","volume-title":"Standard Surveillance vs. Intensive Surveillance in Early Breast Cancer (SURVIVE)","author":"ClinicalTrials.gov","year":"2025","unstructured":"ClinicalTrials.gov: Standard Surveillance vs. Intensive Surveillance in Early Breast Cancer (SURVIVE). 2025. https:\/\/clinicaltrials.gov\/study\/NCT05658172#study-overview"},{"key":"e_1_3_9_28_2","doi-asserted-by":"publisher","DOI":"10.14694\/EdBook_AM.2013.33.e13"},{"key":"e_1_3_9_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.25881"},{"key":"e_1_3_9_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2022.07.007"},{"key":"e_1_3_9_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-021-01594-5"},{"key":"e_1_3_9_32_2","volume-title":"NCCN Guidelines","author":"National Comprehensive Cancer Network","unstructured":"National Comprehensive Cancer Network: NCCN Guidelines. https:\/\/www.nccn.org"}],"container-title":["JCO Precision Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/PO-25-00498","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T20:57:21Z","timestamp":1766091441000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/PO-25-00498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":31,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1200\/PO-25-00498"],"URL":"https:\/\/doi.org\/10.1200\/po-25-00498","relation":{},"ISSN":["2473-4284"],"issn-type":[{"value":"2473-4284","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-06-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-26","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2500498"}}