{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T23:02:16Z","timestamp":1784847736793,"version":"3.55.0"},"reference-count":31,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"9","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Precis Oncol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n            <jats:title>PURPOSE<\/jats:title>\n            <jats:p>A biomarker to help predict outcomes after prostate cancer (PCa) focal therapy would be of considerable interest. We sought to assess the association between treatment failure after focal therapy and the Decipher score, a tumor-based genomic classifier (GC).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>MATERIALS AND METHODS<\/jats:title>\n            <jats:p>\n              We performed a post hoc analysis of a single-center phase II trial (ClinicalTrials.gov identifier:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT03503643\">NCT03503643<\/jats:ext-link>\n              ) in which patients with unilateral grade group (GG) 2-4 PCa (n = 108) underwent hemigland cryoablation of the prostate (2017-2021; n = 108). Pretreatment biopsy tissue was subjected to transcriptomic profiling to generate GC scores. The primary outcome was the association between GC-low (&lt;0.45) versus GC-high (\u22650.45) and in-field recurrence (GG \u22652) on magnetic resonance imaging\u2013guided biopsy 6 months post-treatment, evaluated using multivariable logistic regression.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>\n              In the GC-high group (n = 37), treatment failure occurred in 17 patients (46%). In the GC-low group (n = 71), treatment failure occurred in 15 patients (21%). These differences were statistically significant (odds ratio [OR], 2.61 [95% CI, 1.05 to 6.51];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              = .04). Differences at 18 months were also significant (76%\n              <jats:italic toggle=\"yes\">v<\/jats:italic>\n              44%; OR, 3.58 [95% CI, 1.37 to 9.36],\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              = .009).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION<\/jats:title>\n            <jats:p>In patients with PCa otherwise suitable for management with focal therapy, a high GC score (\u22650.45) was independently associated with treatment failure. A GC score derived from diagnostic biopsy can be used to help predict focal therapy outcomes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1200\/po-25-00535","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T19:59:13Z","timestamp":1758139153000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":3,"title":["Genomic Biomarker for Prostate Cancer Focal Therapy: Post Hoc Assessment of a Phase II Clinical Trial"],"prefix":"10.1200","clinical-trial-number":[{"clinical-trial-number":"nct03503643","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1912-042X","authenticated-orcid":true,"given":"Adam B.","family":"Weiner","sequence":"first","affiliation":[{"name":"Department of Urology, Cedars-Sinai Medical Center, Los Angeles, CA"},{"name":"Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA"},{"name":"Department of Urology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Proudfoot","sequence":"additional","affiliation":[{"name":"Veracyte, Inc. San Diego, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamdouh","family":"Aker","sequence":"additional","affiliation":[{"name":"Department of Urology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Cardenas","sequence":"additional","affiliation":[{"name":"Department of Urology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1156-0620","authenticated-orcid":true,"given":"Samantha","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Urology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Kelly","sequence":"additional","affiliation":[{"name":"Veracyte, Inc. San Diego, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elai","family":"Davicioni","sequence":"additional","affiliation":[{"name":"Veracyte, Inc. San Diego, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Anthony E.","family":"Sisk","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of California- Los Angeles, Los Angeles, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0470-5262","authenticated-orcid":true,"given":"Wayne G.","family":"Brisbane","sequence":"additional","affiliation":[{"name":"Department of Urology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7910-179X","authenticated-orcid":true,"given":"Leonard S.","family":"Marks","sequence":"additional","affiliation":[{"name":"Department of Urology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-023-00702-1"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-020-00315-y"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.12.030"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2024.11.006"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.5692"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(22)00251-0"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.23736\/S2724-6051.20.04160-0"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.11.021"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066855"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2024.03.027"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2024.0019"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/EVIDoa2300018"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.0751"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34790"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.11.024"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-0404"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0702507104"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2020.08.004"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.04.033"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-1587"},{"key":"e_1_3_7_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-021-00416-2"},{"key":"e_1_3_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2024.09.005"},{"key":"e_1_3_7_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-022-02046-4"},{"key":"e_1_3_7_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.05.013"},{"key":"e_1_3_7_26_2","doi-asserted-by":"publisher","DOI":"10.1089\/end.2006.20.688"},{"key":"e_1_3_7_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14809"},{"key":"e_1_3_7_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-024-00905-0"},{"key":"e_1_3_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2022.01.005"},{"key":"e_1_3_7_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41391-024-00907-y"},{"key":"e_1_3_7_31_2","article-title":"Transcriptomic signatures associated with outcomes in recurrent prostate cancer treated with salvage radiation, androgen-deprivation therapy, and enzalutamide: Correlative analysis of the STREAM trial","author":"Bitting RL","unstructured":"Bitting RL, Wu Y, Somarelli JA, et al: Transcriptomic signatures associated with outcomes in recurrent prostate cancer treated with salvage radiation, androgen-deprivation therapy, and enzalutamide: Correlative analysis of the STREAM trial. 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