{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T20:45:08Z","timestamp":1782765908408,"version":"3.54.5"},"reference-count":37,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"6","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Precis Oncol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>Pancreatic ductal adenocarcinoma (PDAC) ranks third in cancer-related deaths. Although national guidelines recommend germline multigene panel testing (MGPT) for all patients with PDAC, only 6%-19% undergo testing, mostly due to under-referral and genetic counselor shortages. We evaluated a coordinator-led and digitally supported workflow designed to increase access to pretest education, improve MGPT uptake, and reduce turnaround time (TAT) for patients newly diagnosed with PDAC at our center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Through the Genetic Information for Treatment Decisions (GIFTD) Initiative, a Genetic Risk Education Coordinator (GREC) served as a liaison between providers, genetic counselors, and patients. Subsequently, we partnered with Nest Genomics to develop the GIFTD Partially Automated Nest Copilot (G-PANC), a digital tool that collects cancer history, delivers genetic education, and assesses MGPT interest before coordinator follow-up. Outcomes included genetic education completion, MGPT uptake, and TAT across sequential phases (baseline, GREC-only, and G-PANC [GREC+ Nest Copilot]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Over 1 year, 354 patients with PDAC were invited to access G-PANC; 73% activated accounts, 80% completed education, and 63% expressed MGPT interest. Among those completing education, 86% engaged with the GREC, and 81% consented to testing, including 15 initially uninterested patients. Of the 127 patients tested, 13% had pathogenic variants. Compared with a baseline\/traditional workflow, the GREC-only phase was associated with increased MGPT uptake (43% to 80%) and reduced TAT (54 to 30 days). During the subsequent G-PANC phase, testing uptake remained high (77%) and TAT further decreased to 22 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>A coordinator-led workflow substantially increased MGPT uptake and reduced TAT. Digital education integration was feasible, maintained high testing rates, and reduced TAT. Prospective evaluation will clarify the independent contributions of digital automation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/po-25-00807","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T19:59:11Z","timestamp":1782763151000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Implementing Timely Germline Genetic Testing for Patients With Pancreatic Cancer Using a Genetics Copilot for Point-of-Care Education and Health Assessment"],"prefix":"10.1200","volume":"10","author":[{"given":"Sophie","family":"Moravec","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura V.","family":"Barton","sequence":"additional","affiliation":[{"name":"Department of Pathology, Moffitt Cancer Center, Tampa, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Revathy","family":"Suresh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Moffitt Cancer Center, Tampa, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Hayward","sequence":"additional","affiliation":[{"name":"Nest Genomics, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Schmidlen","sequence":"additional","affiliation":[{"name":"Nest Genomics, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6675-0037","authenticated-orcid":true,"given":"Jessica N. Rivera","family":"Rivera","sequence":"additional","affiliation":[{"name":"Healthcare Delivery Research Network, MedStar Health Research Institute, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9537-578X","authenticated-orcid":true,"given":"Toni","family":"Basinski","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solomon","family":"Alhassan","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7392-6336","authenticated-orcid":true,"given":"Nicole","family":"Nardella","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrianna","family":"Oraiqat","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Craig","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1041-2490","authenticated-orcid":true,"given":"Carmelo J.","family":"Blanquicett","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2872-3011","authenticated-orcid":true,"given":"Satish S.","family":"Maharaj","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Blue","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8448-844X","authenticated-orcid":true,"given":"Richard","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6832-2485","authenticated-orcid":true,"given":"Tiago","family":"Biachi De Castria","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mokenge","family":"Malafa","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6031-6451","authenticated-orcid":true,"given":"Andrew J.","family":"Sinnamon","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8573-7364","authenticated-orcid":true,"given":"Allan Lima","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Hoffe","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela J.","family":"Hodul","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan T.","family":"Vadaparampil","sequence":"additional","affiliation":[{"name":"Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL"},{"name":"Office of Community Outreach and Engagement, Moffitt Cancer Center, Tampa, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2489-3099","authenticated-orcid":true,"given":"Teresa T.","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Pathology, Moffitt Cancer Center, Tampa, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2314-0164","authenticated-orcid":true,"given":"J. Kevin","family":"Hicks","sequence":"additional","affiliation":[{"name":"Department of Pathology, Moffitt Cancer Center, Tampa, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moran","family":"Snir","sequence":"additional","affiliation":[{"name":"Nest Genomics, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4726-9264","authenticated-orcid":true,"given":"Jennifer B.","family":"Permuth","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL"},{"name":"Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_7_2_2","volume-title":"Surveillance Research Program","author":"SEER*Explorer","year":"2025","unstructured":"SEER*Explorer: An interactive website for SEER cancer statistics. Surveillance Research Program, National Cancer Institute; 2025. Data source(s): SEER Incidence Data, November 2024 Submission (1975-2022), SEER 21 registries. https:\/\/seer.cancer.gov\/statistics-network\/explorer\/"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/oncolo\/oyad080"},{"key":"e_1_3_7_4_2","volume-title":"Genetic\/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic (Version 3.2025)","author":"National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology","year":"2025","unstructured":"National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology: Genetic\/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic (Version 3.2025). National Comprehensive Cancer Network, Inc. 2025. https:\/\/www.nccn.org"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.27.0660"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.02764"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.03661"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2021.102337"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/17588359231189127"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2024.42.3_suppl.703"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1200\/OP.20.00678"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2021-108054"},{"key":"e_1_3_7_13_2","first-page":"462","article-title":"Risk assessment and genetic testing for inherited gastrointestinal syndromes","volume":"15","author":"Stoll J","year":"2019","unstructured":"Stoll J, Kupfer SS: Risk assessment and genetic testing for inherited gastrointestinal syndromes. Gastroenterol Hepatol 15:462-470, 2019","journal-title":"Gastroenterol Hepatol"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.path.2022.05.004"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.9526"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/onco.13968"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-022-00300-5"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-018-0106-2"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-024-00389-w"},{"key":"e_1_3_7_20_2","first-page":"636","article-title":"Genetic counseling","volume":"26","author":"Fraser FC","year":"1974","unstructured":"Fraser FC: Genetic counseling. Am J Hum Genet 26:636-661, 1974","journal-title":"Am J Hum Genet"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20000918)94:3<189::AID-AJMG3>3.0.CO;2-E"},{"key":"e_1_3_7_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320370419"},{"key":"e_1_3_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-3991(00)00181-6"},{"key":"e_1_3_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2020.12.024"},{"key":"e_1_3_7_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122648"},{"key":"e_1_3_7_26_2","first-page":"497","article-title":"Feasibility of the genetic information assistant chatbot to provide genetic education and study genetic test adoption among pancreatic cancer patients at Johns Hopkins Hospital","volume":"2023","author":"Soley N","year":"2023","unstructured":"Soley N, Klein A, Taylor CO, et al: Feasibility of the genetic information assistant chatbot to provide genetic education and study genetic test adoption among pancreatic cancer patients at Johns Hopkins Hospital. AMIA Jt Summits Transl Sci Proc 2023:497-504, 2023","journal-title":"AMIA Jt Summits Transl Sci Proc"},{"key":"e_1_3_7_27_2","volume-title":"How to Improve: Model for Improvement: Establishing Measures","unstructured":"How to Improve: Model for Improvement: Establishing Measures. Institute for Healthcare Improvement. https:\/\/www.ihi.org\/library\/model-for-improvement\/establishing-measures"},{"key":"e_1_3_7_28_2","volume-title":"Types of Health Care Quality Measures","unstructured":"Types of Health Care Quality Measures | Agency for Healthcare Research and Quality. https:\/\/www.ahrq.gov\/talkingquality\/measures\/types.html"},{"key":"e_1_3_7_29_2","doi-asserted-by":"publisher","DOI":"10.2196\/59464"},{"key":"e_1_3_7_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.30"},{"key":"e_1_3_7_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20880"},{"key":"e_1_3_7_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djac069"},{"key":"e_1_3_7_33_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13020198"},{"key":"e_1_3_7_34_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.6228"},{"key":"e_1_3_7_35_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.13900"},{"key":"e_1_3_7_36_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16203447"},{"key":"e_1_3_7_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.3567"},{"key":"e_1_3_7_38_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13071566"}],"container-title":["JCO Precision Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/PO-25-00807","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T19:59:19Z","timestamp":1782763159000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/PO-25-00807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1200\/PO-25-00807"],"URL":"https:\/\/doi.org\/10.1200\/po-25-00807","relation":{},"ISSN":["2473-4284"],"issn-type":[{"value":"2473-4284","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2025-08-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-03","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2500807"}}