{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:24:56Z","timestamp":1793118296951,"version":"4.5.0"},"reference-count":40,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"5","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Precis Oncol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">NTRK<\/jats:italic>\n                      gene fusions are oncogenic drivers for a variety of adult and pediatric tumors, making them a target for tumor-agnostic precision medicine. Tropomyosin receptor kinase (TRK) inhibitors are approved by the US Food and Drug Administration for cancers driven by TRK fusions. However,\n                      <jats:italic toggle=\"yes\">NTRK<\/jats:italic>\n                      genes can fuse with many different partner genes, leading to diverse TRK fusion proteins, highlighting the importance of identifying the specific fusion partner with optimal pan-cancer diagnostics. This analysis aims to provide an updated descriptive compendium of\n                      <jats:italic toggle=\"yes\">NTRK<\/jats:italic>\n                      gene fusions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">NTRK<\/jats:italic>\n                      gene fusions were identified via literature searches (PubMed), a search of a clinical trials database (larotrectinib), and searches of two genomic databases (Memorial Sloan Kettering and Children's Hospital of Philadelphia).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      In total, 358 distinct\n                      <jats:italic toggle=\"yes\">NTRK<\/jats:italic>\n                      gene fusion-tumor pairings were identified across 25 tumor types. Primary CNS tumors were observed to harbor 86 distinct\n                      <jats:italic toggle=\"yes\">NTRK<\/jats:italic>\n                      gene fusions, followed by sarcomas (n = 73). Overall, 229 different fusion partners were identified across tumor types (regardless of\n                      <jats:italic toggle=\"yes\">NTRK<\/jats:italic>\n                      gene). Twenty-three fusion partners were found to fuse with &gt;1\n                      <jats:italic toggle=\"yes\">NTRK<\/jats:italic>\n                      gene across tumor types, while 183 fusion partners were associated with only a single\n                      <jats:italic toggle=\"yes\">NTRK<\/jats:italic>\n                      gene in one tumor type.\n                      <jats:italic toggle=\"yes\">ETV6<\/jats:italic>\n                      ::\n                      <jats:italic toggle=\"yes\">NTRK3<\/jats:italic>\n                      was found in the highest number of different tumor types.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      This analysis illustrates the diversity of\n                      <jats:italic toggle=\"yes\">NTRK<\/jats:italic>\n                      gene fusion partners across various tumor types and highlights the importance of selecting a pan-tumor fusion-partner agnostic test that can identify both known and novel fusion partners to identify patients who may benefit from treatment with TRK inhibitors.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/po-25-01150","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T19:59:08Z","timestamp":1778097548000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":2,"title":["<i>NTRK<\/i>\n                    Gene Fusions: A Compendium of Fusion Partners and Tumor Types"],"prefix":"10.1200","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1051-502X","authenticated-orcid":true,"given":"Soo-Ryum","family":"Yang","sequence":"first","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center, New York, 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