{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T01:37:38Z","timestamp":1773884258681,"version":"3.50.1"},"reference-count":16,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"3","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Precis Oncol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"\n PURPOSE<\/jats:title>\n Although we typically consider diffuse pleural mesothelioma (DPM) as a disease of elderly males with a history of asbestos exposure, young individuals are also affected. Given the increasing incidence of cancer in young individuals, we investigated the characteristics and underlying biology of young patients with DPM.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n We identified patients with DPM age \u226450 years from Memorial Sloan Kettering Cancer Center (1990-2023). Clinicopathologic and genetic characteristics were compared between very young (\u226435 years) and young (36-50 years) patients.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n We identified 273 patients with DPM age \u226450 years; 39% were female, 40% had a history of self-reported occupational asbestos exposure (very young, 16%\n v<\/jats:italic>\n young, 45%;\n P<\/jats:italic>\n < .01), 16% had a personal history of cancer (very young, 7%\n v<\/jats:italic>\n young, 18%;\n P<\/jats:italic>\n = .07), and 70% had a family history of cancer (most commonly breast, lung, and colon). Most frequently altered somatic genes (51\/273 tested; 46\/51 positive) included\n BAP1<\/jats:italic>\n (22\/47, 47%),\n NF2<\/jats:italic>\n (18\/47, 38%),\n CDKN2A\/B<\/jats:italic>\n (12\/48, 25%), and\n TP53<\/jats:italic>\n (10\/48, 21%). Very young patients had less somatic alterations in\n BAP1<\/jats:italic>\n (13%\n v<\/jats:italic>\n 63%,\n P<\/jats:italic>\n < .01) and a lower tumor mutational burden (0.9\n v<\/jats:italic>\n 1.8 mut\/mB,\n P<\/jats:italic>\n < .01); they were less frequently carriers of germline alterations (0% [0\/8]\n v<\/jats:italic>\n 43% [6\/14],\n P<\/jats:italic>\n = .05). Somatic alterations in\n CDKN2B<\/jats:italic>\n were more frequent among females (females 42%\n v<\/jats:italic>\n males 12%,\n P<\/jats:italic>\n = .03).\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n Young patients with DPM have strong personal and family histories of cancer, and heterogeneous somatic and germline alterations, indicating divergent underlying biology. With the increasing prevalence of young adults with cancers, mesotheliomas, although uncommon, should be on the differential for patients even without asbestos exposure history in this age group.<\/jats:p>\n <\/jats:sec>","DOI":"10.1200\/po-25-01171","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T19:59:10Z","timestamp":1773863950000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Diffuse Pleural Mesothelioma in Young (Age \u226450 Years) and Very Young (Age \u226435 Years) Patients: Clinical Characteristics, Genomics, and Survival"],"prefix":"10.1200","volume":"10","author":[{"given":"Hely","family":"Ollila","sequence":"first","affiliation":[{"name":"Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4892-4185","authenticated-orcid":true,"given":"Amina","family":"Tidjani","sequence":"additional","affiliation":[{"name":"Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6987-2294","authenticated-orcid":true,"given":"Jennifer L.","family":"Sauter","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1051-502X","authenticated-orcid":true,"given":"Soo-Ryum","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0867-3694","authenticated-orcid":true,"suffix":"II","given":"Charles B.","family":"Simone","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7959-3018","authenticated-orcid":true,"given":"Michael","family":"Offin","sequence":"additional","affiliation":[{"name":"Thoracic Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1699-2046","authenticated-orcid":true,"given":"Prasad S.","family":"Adusumilli","sequence":"additional","affiliation":[{"name":"Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","reference":[{"key":"e_1_3_9_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.10218"},{"key":"e_1_3_9_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.108"},{"key":"e_1_3_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2024.02.002"},{"key":"e_1_3_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2020.09.011"},{"key":"e_1_3_9_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2023-108983"},{"key":"e_1_3_9_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000864"},{"key":"e_1_3_9_8_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-24-0085"},{"key":"e_1_3_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2014.12.006"},{"key":"e_1_3_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2014.04.040"},{"key":"e_1_3_9_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04761-9"},{"key":"e_1_3_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2025.100706"},{"key":"e_1_3_9_13_2","first-page":"2108","article-title":"Homozygous deletion of CDKN2A and codeletion of the methylthioadenosine phosphorylase gene in the majority of pleural mesotheliomas","volume":"9","author":"Illei PB","year":"2003","unstructured":"Illei PB, Rusch VW, Zakowski MF, et al: Homozygous deletion of CDKN2A and codeletion of the methylthioadenosine phosphorylase gene in the majority of pleural mesotheliomas. Clin Cancer Res 9:2108-2113, 2003","journal-title":"Clin Cancer Res"},{"key":"e_1_3_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2025.06.020"},{"key":"e_1_3_9_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3520"},{"key":"e_1_3_9_16_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-18-0804"},{"key":"e_1_3_9_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41389-021-00357-4"}],"container-title":["JCO Precision Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/PO-25-01171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T19:59:14Z","timestamp":1773863954000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/PO-25-01171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1200\/PO-25-01171"],"URL":"https:\/\/doi.org\/10.1200\/po-25-01171","relation":{},"ISSN":["2473-4284"],"issn-type":[{"value":"2473-4284","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-12-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-15","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2501171"}}