{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T20:52:55Z","timestamp":1786135975246,"version":"build-2736575974"},"reference-count":48,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"8","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Precis Oncol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>Motivated by the rising incidence of cancers at younger ages, this study compares tumor genomic alterations between adolescents and young adults (AYAs; 18-39 years) and non-AYAs (40 years and older) and explores the relationship with continuous age in patients with relapsed\/refractory ovarian, breast, and colorectal cancers accrued to the NCI-MATCH trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Tumor genomic profiles generated by a next-generation sequencing 143-gene panel (NCI-MATCH assay, v2) were analyzed for association with age (AYA\/total: 21\/455 ovarian, 27\/576 breast, 43\/759 colorectal cancers). For each gene, AYA and non-AYA DNA alteration proportions were compared (Fisher exact test) and alteration association with continuous age (logistic regression) was evaluated (false discovery rate\u2011adjusted\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value &lt;.1 statistically significant). For colorectal cancer, sex-stratified analysis was also performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      No significant AYA versus non-AYA differences were observed in the prevalence of gene mutations (single nucleotide variant [SNV]\/indel). A significant association of gene amplification with AYAs (odds ratio [OR], 95% CI) was\n                      <jats:italic toggle=\"yes\">CCND1<\/jats:italic>\n                      (0.2, 0.1-0.4), favoring AYAs in breast cancer. Examining age as a continuous variable, significant associations of gene mutations (SNV\/indel) with older age, expressed as 5-year OR (OR [95% CI]), were observed:\n                      <jats:italic toggle=\"yes\">TP53<\/jats:italic>\n                      (1.3 [1.1 to 1.4]), ovarian cancer;\n                      <jats:italic toggle=\"yes\">CDH1<\/jats:italic>\n                      (1.4 [1.2 to 1.6]) and\n                      <jats:italic toggle=\"yes\">PIK3CA<\/jats:italic>\n                      (1.1 [1.1 to 1.2]), breast cancer; and\n                      <jats:italic toggle=\"yes\">BRAF<\/jats:italic>\n                      (1.4 [1.2 to 1.7]), female colorectal cancer. Associations with younger age included\n                      <jats:italic toggle=\"yes\">SMAD4<\/jats:italic>\n                      (0.8 [0.7 to 0.9]), male colorectal cancer. Significant associations of gene amplification with age (continuous) were as follows:\n                      <jats:italic toggle=\"yes\">CCNE1<\/jats:italic>\n                      (1.3 [1.1 to 1.6]), older ovarian cancer, and\n                      <jats:italic toggle=\"yes\">CCND1<\/jats:italic>\n                      (0.8 [0.8 to 0.9]), younger breast cancer.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      Comparing AYAs with non-AYAs among patients having relapsed\/refractory disease, no significant differences in SNV\/indel prevalence were observed, but\n                      <jats:italic toggle=\"yes\">CCND1<\/jats:italic>\n                      amplifications were more prevalent in AYA breast cancer. For several genes, DNA alterations were associated with continuous age and may depend on sex in colorectal cancer.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/po-25-01183","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T19:59:11Z","timestamp":1786132751000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Associations of Age With Tumor Genomic Characteristics in Relapsed\/Refractory Cancers Interrogated With the NCI-MATCH Trial Targeted Gene Panel Assay"],"prefix":"10.1200","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0666-2630","authenticated-orcid":true,"given":"Hari","family":"Sankaran","sequence":"first","affiliation":[{"name":"Biometric Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, 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