{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:46:18Z","timestamp":1785876378902,"version":"3.56.0"},"reference-count":26,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"8","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Precis Oncol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"\n PURPOSE<\/jats:title>\n \n Isocitrate dehydrogenase 1 and 2 (\n IDH1<\/jats:italic>\n and\n IDH2<\/jats:italic>\n ) mutations are common in intrahepatic cholangiocarcinoma (ICC), but their prognostic value is unclear. Using a large data set, we assessed their impact in resected and nonresected ICC.\n <\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n Adults from two medical centers (MSKCC and Erasmus) with ICC treated with curative-intent resection (resected) or managed nonoperatively (unresectable) who underwent next-generation sequencing were analyzed retrospectively. Kaplan-Meier and Cox regressions assessed the impact of IDH status on outcomes.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n Of the 795 patients analyzed, 25% had\n IDH1\/2<\/jats:italic>\n mutations (\n IDH<\/jats:italic>\n mut) and 43% underwent resection. Median overall survival (OS) of the cohort was 32 months in\n IDH<\/jats:italic>\n mut and 28 months for\n IDH<\/jats:italic>\n wt (\n P<\/jats:italic>\n = .2). High-risk genetic alterations (\n TP53<\/jats:italic>\n mut,\n KRAS<\/jats:italic>\n mut, and\n CDKN2A<\/jats:italic>\n del) were more frequent in\n IDH<\/jats:italic>\n wild-type (\n IDH<\/jats:italic>\n wt; odds ratio, 2.26; q < 0.001). OS was 19 months in patients with high-risk alterations versus 40 months in patients without (\n P<\/jats:italic>\n < .001). In resected patients, recurrence-free survival (RFS) in\n IDH<\/jats:italic>\n mut was 20 months versus 14 months for\n IDH<\/jats:italic>\n wt (\n P<\/jats:italic>\n = .018), and OS was 69 months versus 50 months, respectively (\n P<\/jats:italic>\n = .2). However, after controlling for high-risk alterations, the potential benefit of\n IDH<\/jats:italic>\n mut was no longer apparent (RFS: hazard ratio [HR], 0.78;\n P<\/jats:italic>\n = .095; OS: HR, 0.88;\n P<\/jats:italic>\n = .4). In unresectable\n IDH<\/jats:italic>\n mut patients, progression-free survival was 9.4 months versus 9.1 months for\n IDH<\/jats:italic>\n wt (\n P<\/jats:italic>\n = .7), and OS was 22 months versus 18 months, respectively (\n P<\/jats:italic>\n = .13). There remained no differences after controlling for high-risk alterations.\n IDH<\/jats:italic>\n status was not a significant survival predictor in multivariable models.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n \n In this cohort of patients with ICC,\n IDH<\/jats:italic>\n mut was not an independent predictor of survival, after controlling for high-risk alterations and clinical variables.\n IDH<\/jats:italic>\n mutational status alone should, therefore, not be used to guide prognosis.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1200\/po-25-01261","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T19:59:13Z","timestamp":1785873553000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating the Prognostic Impact of IDH Mutations in Intrahepatic Cholangiocarcinoma"],"prefix":"10.1200","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0156-5236","authenticated-orcid":true,"given":"Rachel N.","family":"Harvey","sequence":"first","affiliation":[{"name":"Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7270-8249","authenticated-orcid":true,"given":"Rebecca","family":"Gelfer","sequence":"additional","affiliation":[{"name":"Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3315-4538","authenticated-orcid":true,"given":"Esther","family":"Drill","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Biostatistics Service, Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Balachandran","sequence":"additional","affiliation":[{"name":"Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY"},{"name":"Weill Cornell Medical College, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"D'Angelica","sequence":"additional","affiliation":[{"name":"Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY"},{"name":"Weill Cornell Medical College, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Drebin","sequence":"additional","affiliation":[{"name":"Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY"},{"name":"Weill Cornell Medical College, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4595-8749","authenticated-orcid":true,"given":"T Peter","family":"Kingham","sequence":"additional","affiliation":[{"name":"Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY"},{"name":"Weill Cornell Medical College, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily","family":"Saadat","sequence":"additional","affiliation":[{"name":"Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0406-017X","authenticated-orcid":true,"given":"Kevin","family":"Soares","sequence":"additional","affiliation":[{"name":"Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY"},{"name":"Weill Cornell Medical College, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2505-959X","authenticated-orcid":true,"given":"Alice C.","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY"},{"name":"Weill Cornell Medical College, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1522-8054","authenticated-orcid":true,"given":"Ghassan K.","family":"Abou-Alfa","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical College, New York, NY"},{"name":"Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY"},{"name":"Trinity College Dublin School of Medicine, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5054-8192","authenticated-orcid":true,"given":"Andrea","family":"Cercek","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical College, New York, NY"},{"name":"Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, 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