{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:43:32Z","timestamp":1789519412402,"version":"build-2803163510"},"reference-count":36,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"9","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Precis Oncol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Pediatric cancer care in Spain lacked a national personalized medicine program. The SEHOP-PENCIL initiative, established by the SEHOP, was designed to address this gap. A national survey identified the genomic sequencing needs of hospitals treating pediatric patients with cancer. Results showed improved access to targeted next-generation sequencing panels but revealed persistent variability in implementation, limited availability of advanced sequencing (whole-exome sequencing, whole-genome sequencing, RNA sequencing, and DNA methylation profiling), and gaps in cancer predisposition clinics and molecular tumor boards (MTBs). SEHOP-PENCIL is organized as a network of 10 specialized genomic centers serving 45 hospitals through a centralized inclusion system. The program standardizes patient eligibility, genomic workflows, and result interpretation, supported by a national MTB. This framework enables informed clinical decision making, ensures access to molecular diagnosis and innovative therapies, and supports systematic data collection to advance pediatric cancer research and personalized care. SEHOP-PENCIL represents a pioneering national model for integrating precision oncology into pediatric cancer care in Spain. By fostering collaboration, standardizing genomic practices, and promoting equitable access, it aims to reduce disparities and improve outcomes, offering a scalable example for other decentralized health care systems.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/po-26-00074","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T19:59:08Z","timestamp":1788292748000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Establishing a Multicenter Personalized Medicine Program in Childhood, Adolescent, and Young Adult Cancer in Spain: The SEHOP-PENCIL Project"],"prefix":"10.1200","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5083-6944","authenticated-orcid":true,"given":"Andrea","family":"Vilaplana","sequence":"first","affiliation":[{"name":"Childhood Cancer and Blood Disorders Group, Vall d'Hebron Research Institute (VHIR), Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4642-4233","authenticated-orcid":true,"given":"Asbleidy","family":"Carolina Torres","sequence":"additional","affiliation":[{"name":"Childhood Cancer and Blood Disorders Group, Vall d'Hebron Research Institute (VHIR), Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8101-4014","authenticated-orcid":true,"given":"Adela","family":"Escudero L\u00f3pez","sequence":"additional","affiliation":[{"name":"Institute of Medical and Molecular Genetics (INGEMM), La Paz University Hospital, Madrid, Spain"},{"name":"CIBERER-ISCIII, IdiPAZ-CNIO Translational Research Unit in Pediatric Hemato-Oncology, La Paz University Hospital Research Institute (IdiPAZ), Spanish National Cancer Center, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3054-5832","authenticated-orcid":true,"given":"Elisa","family":"Izquierdo","sequence":"additional","affiliation":[{"name":"Institute of Medical and Molecular Genetics (INGEMM), La Paz University Hospital, Madrid, Spain"},{"name":"CIBERER-ISCIII, IdiPAZ-CNIO Translational Research Unit in Pediatric Hemato-Oncology, La Paz University Hospital Research Institute (IdiPAZ), Spanish National Cancer Center, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6757-0177","authenticated-orcid":true,"given":"Sergio","family":"Manresa-Vera","sequence":"additional","affiliation":[{"name":"Childhood Cancer and Blood Disorders Group, Vall d'Hebron Research Institute (VHIR), Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1598-0633","authenticated-orcid":true,"given":"Josep","family":"Escriv\u00e1-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Clinical and Translational Research in Cancer, Instituto de Investigaci\u00f3n Sanitaria la Fe, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5642-115X","authenticated-orcid":true,"given":"Piedad","family":"Alba-Pav\u00f3n","sequence":"additional","affiliation":[{"name":"Paediatric Oncology Group, Biobizkaia Health Research Institute, Barakaldo, Bizkaia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5203-9191","authenticated-orcid":true,"given":"Lide","family":"Ala\u00f1a","sequence":"additional","affiliation":[{"name":"Paediatric Oncology Group, Biobizkaia Health Research Institute, Barakaldo, Bizkaia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8679-6868","authenticated-orcid":true,"given":"Angela","family":"Gutierrez-Camino","sequence":"additional","affiliation":[{"name":"Paediatric Oncology Group, Biobizkaia Health Research Institute, Barakaldo, Bizkaia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6682-0771","authenticated-orcid":true,"given":"Carlos","family":"Rodr\u00edguez-Antol\u00edn","sequence":"additional","affiliation":[{"name":"Institute of Medical and Molecular Genetics (INGEMM), La Paz University Hospital, Madrid, Spain"},{"name":"Cancer Epigenetics Laboratory-Biomarkers and Experimental Therapeutics in Cancer, La Paz University Hospital Research Institute (IdiPAZ), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9085-1336","authenticated-orcid":true,"given":"Clara","family":"Venegas Mascar\u00f3","sequence":"additional","affiliation":[{"name":"Institute of Medical and Molecular Genetics (INGEMM), La Paz University Hospital, Madrid, Spain"},{"name":"CIBERER-ISCIII, IdiPAZ-CNIO Translational Research Unit in Pediatric Hemato-Oncology, La Paz University Hospital Research Institute (IdiPAZ), Spanish National Cancer Center, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7151-8144","authenticated-orcid":true,"given":"Sonia","family":"Paco Mercader","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Oncology, Pediatric Cancer Center Barcelona, Hospital-Fundaci\u00f3n Sant Joan de D\u00e9u, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3139-4826","authenticated-orcid":true,"given":"Noelia","family":"Salvador","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Oncology, Pediatric Cancer Center Barcelona, Hospital-Fundaci\u00f3n Sant Joan de D\u00e9u, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Chamorro-Vera","sequence":"additional","affiliation":[{"name":"Paediatric Oncology and Haematology Department, Hospital Infantil Universitario Ni\u00f1o Jes\u00fas, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5285-3019","authenticated-orcid":true,"given":"Teresa","family":"Im\u00edzcoz","sequence":"additional","affiliation":[{"name":"Unidad de Gen\u00f3mica, CIMA Lab Diagnostics, Cl\u00ednica Universidad de Navarra (CUN), Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7278-0008","authenticated-orcid":true,"given":"Elena","family":"Panizo Morgado","sequence":"additional","affiliation":[{"name":"Departamento de Pediatr\u00eda y Cancer Center, Cl\u00ednica Universidad de Navarra (CUN), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8838-1631","authenticated-orcid":true,"given":"Beatriz","family":"Vergara-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Paediatric Oncology and Haematology Department, Hospital Infantil Universitario Ni\u00f1o Jes\u00fas, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2662-7632","authenticated-orcid":true,"given":"Antonio","family":"Juan-Ribelles","sequence":"additional","affiliation":[{"name":"Paediatric Oncology Unit, Hospital Universitari i Polit\u00e8cnic La Fe, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5604-8818","authenticated-orcid":true,"given":"Nuria","family":"Benavent","sequence":"additional","affiliation":[{"name":"Clinical and Translational Research in Cancer, Instituto de Investigaci\u00f3n Sanitaria la Fe, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3678-1657","authenticated-orcid":true,"given":"Alicia","family":"Casta\u00f1eda Heredia","sequence":"additional","affiliation":[{"name":"Paediatric Solid Tumour Unit, Paediatric Cancer Center Barcelona, Hospital Sant Joan de D\u00e9u, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0174-674X","authenticated-orcid":true,"given":"Carlota","family":"Rovira Zurriaga","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Sant Joan de D\u00e9u, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8507-1670","authenticated-orcid":true,"given":"Lorena","family":"Valero-Arrese","sequence":"additional","affiliation":[{"name":"Childhood Cancer and Blood Disorders Group, Vall d'Hebron Research Institute (VHIR), Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"},{"name":"Paediatric Oncology and Haematology Department, Vall d'Hebron University Hospital, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3886-3085","authenticated-orcid":true,"given":"Raquel","family":"D\u00edaz-Merch\u00e1n","sequence":"additional","affiliation":[{"name":"Servicio de Pediatr\u00eda, Complejo Hospitalario Universitario de Toledo, Toledo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7759-9652","authenticated-orcid":true,"given":"Irene","family":"Manzano-Benito","sequence":"additional","affiliation":[{"name":"Servicio de Anatom\u00eda Patol\u00f3gica, Complejo Hospitalario Universitario de Toledo, Toledo, Spain"},{"name":"Grupo de Estudio de Tumores del Sistema Nervioso Central, Fundaci\u00f3n Hospital Nacional de Parapl\u00e9jicos (FHNP), Instituto de Investigaci\u00f3n Sanitaria de Castilla-La Mancha (IDISCAM), Toledo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8837-5346","authenticated-orcid":true,"given":"Saint T.","family":"Cervera","sequence":"additional","affiliation":[{"name":"Unidad de Tumores S\u00f3lidos Infantiles, Instituto de Investigaci\u00f3n de Enfermedades Raras, Instituto de Salud Carlos III, Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras, Instituto de Salud Carlos III (CB06\/07\/1009, CIBERER-ISCIII), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5996-2496","authenticated-orcid":true,"given":"Laura","family":"Garc\u00eda-Calvo","sequence":"additional","affiliation":[{"name":"Unidad de Tumores S\u00f3lidos Infantiles, Instituto de Investigaci\u00f3n de Enfermedades Raras, Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3544-4045","authenticated-orcid":true,"given":"Irene","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Paediatric Oncology Unit, Virgen de la Arrixaca University Clinical Hospital, Murcia, Spain"},{"name":"Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8452-7963","authenticated-orcid":true,"given":"Nerea","family":"Dom\u00ednguez-Pinilla","sequence":"additional","affiliation":[{"name":"Paediatric Haematology and Oncology Unit, i+12 Research Institute, 12 de Octubre University Hospital, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3222-5955","authenticated-orcid":true,"given":"Cristina","family":"Nova-Lozano","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario de Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Cuadrado-Torroglosa","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n CRIS Contra el C\u00e1ncer, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"S\u00e1nchez-Ruiz","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n CRIS Contra el C\u00e1ncer, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Mondejar","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n CRIS Contra el C\u00e1ncer, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6436-9195","authenticated-orcid":true,"given":"Antonio","family":"P\u00e9rez-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"CIBERER-ISCIII, IdiPAZ-CNIO Translational Research Unit in Pediatric Hemato-Oncology, La Paz University Hospital Research Institute (IdiPAZ), Spanish National Cancer Center, Madrid, Spain"},{"name":"Paediatric Haematology and Oncology Department, La Paz University Hospital, Madrid, Spain"},{"name":"Paediatric Department at Faculty of Medicine, Universidad Aut\u00f3noma de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2359-9330","authenticated-orcid":true,"given":"Ana","family":"Fern\u00e1ndez-Teijeiro","sequence":"additional","affiliation":[{"name":"Paediatric Oncology and Haematology Unit, Hospital Universitario Virgen Macarena, Sevilla University, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0763-7552","authenticated-orcid":true,"given":"Palma","family":"Solano-P\u00e1ez","sequence":"additional","affiliation":[{"name":"Paediatric Oncology Unit, Hospital Infantil Virgen del Roc\u00edo, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7692-6123","authenticated-orcid":true,"given":"Josep","family":"Roma","sequence":"additional","affiliation":[{"name":"Childhood Cancer and Blood Disorders Group, Vall d'Hebron Research Institute (VHIR), Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6816-2095","authenticated-orcid":true,"given":"Jaime","family":"Font de Mora","sequence":"additional","affiliation":[{"name":"Clinical and Translational Research in Cancer, Instituto de Investigaci\u00f3n Sanitaria la Fe, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5004-8895","authenticated-orcid":true,"given":"B\u00e1rbara","family":"Mel\u00e9ndez","sequence":"additional","affiliation":[{"name":"Servicio de Anatom\u00eda Patol\u00f3gica, Complejo Hospitalario Universitario de Toledo, Toledo, Spain"},{"name":"Grupo de Estudio de Tumores del Sistema Nervioso Central, Fundaci\u00f3n Hospital Nacional de Parapl\u00e9jicos (FHNP), Instituto de Investigaci\u00f3n Sanitaria de Castilla-La Mancha (IDISCAM), Toledo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6426-7423","authenticated-orcid":true,"given":"Alba","family":"Rubio-San-Sim\u00f3n","sequence":"additional","affiliation":[{"name":"Paediatric Oncology and Haematology Department, Hospital Infantil Universitario Ni\u00f1o Jes\u00fas, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8094-5992","authenticated-orcid":true,"given":"Cristina","family":"Saiz-Ladera","sequence":"additional","affiliation":[{"name":"Oncogenomic Unit, Paediatric Oncology and Haematology Department, Hospital Infantil Universitario Ni\u00f1o Jes\u00fas Research Foundation, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5012-0137","authenticated-orcid":true,"given":"Itziar","family":"Astigarraga","sequence":"additional","affiliation":[{"name":"Paediatric Oncology Group, Biobizkaia Health Research Institute, Barakaldo, Bizkaia, Spain"},{"name":"Paediatrics Department, Faculty of Medicine and Nursing, Hospital Universitario Cruces, University of the Basque Country, Barakaldo, Bizkaia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5669-5097","authenticated-orcid":true,"given":"Adela","family":"Ca\u00f1ete","sequence":"additional","affiliation":[{"name":"Paediatric Oncology Unit, Hospital Universitari i Polit\u00e8cnic La Fe, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6287-8391","authenticated-orcid":true,"given":"Javier","family":"Alonso","sequence":"additional","affiliation":[{"name":"Unidad de Tumores S\u00f3lidos Infantiles, Instituto de Investigaci\u00f3n de Enfermedades Raras, Instituto de Salud Carlos III, Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras, Instituto de Salud Carlos III (CB06\/07\/1009, CIBERER-ISCIII), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9630-3676","authenticated-orcid":true,"given":"Cinzia","family":"Lavarino","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Oncology, Pediatric Cancer Center Barcelona, Hospital-Fundaci\u00f3n Sant Joan de D\u00e9u, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4066-8203","authenticated-orcid":true,"given":"Ana","family":"Pati\u00f1o-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Departamento de Pediatr\u00eda y Cancer Center Cl\u00ednica Universidad de Navarra (CUN), Unidad de Medicina Gen\u00f3mica, Laboratorio de Terapias Avanzadas para Tumores S\u00f3lidos Pedi\u00e1tricos, Programa de Tumores S\u00f3lidos, CIMA Universidad de Navarra, Instituto de Investigaci\u00f3n Sanitaria de Navarra (IdiSNA), Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0708-1670","authenticated-orcid":true,"given":"Lucas","family":"Moreno","sequence":"additional","affiliation":[{"name":"Childhood Cancer and Blood Disorders Group, Vall d'Hebron Research Institute (VHIR), Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"},{"name":"Paediatric Oncology and Haematology Department, Vall d'Hebron University Hospital, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9659-1471","authenticated-orcid":true,"given":"Aroa","family":"Soriano","sequence":"additional","affiliation":[{"name":"Childhood Cancer and Blood Disorders Group, Vall d'Hebron Research Institute (VHIR), Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the SEHOP-PENCIL Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_9_2_2","article-title":"Precision medicine for childhood cancer: Current limitations and future perspectives","author":"McCabe MG","unstructured":"McCabe MG, Geoerger B, Chesler L, et al: Precision medicine for childhood cancer: Current limitations and future perspectives. JCO Precis Oncol 10.1200\/PO.23.00117","journal-title":"JCO Precis Oncol"},{"key":"e_1_3_9_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-019-0169-x"},{"key":"e_1_3_9_4_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-21-1136"},{"key":"e_1_3_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.06.009"},{"key":"e_1_3_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2022.09.001"},{"key":"e_1_3_9_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.02838"},{"key":"e_1_3_9_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2015.5689"},{"key":"e_1_3_9_9_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-24-0916"},{"key":"e_1_3_9_10_2","article-title":"Diagnostic yield from a nationwide implementation of precision medicine for all children with cancer","author":"Wadensten E","unstructured":"Wadensten E, Wessman S, Abel F, et al: Diagnostic yield from a nationwide implementation of precision medicine for all children with cancer. JCO Precis Oncol 10.1200\/PO.23.00039","journal-title":"JCO Precis Oncol"},{"key":"e_1_3_9_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-1072-4"},{"key":"e_1_3_9_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03044-0"},{"key":"e_1_3_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2024.101183"},{"key":"e_1_3_9_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12687-020-00503-2"},{"key":"e_1_3_9_15_2","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.AM2025-1204"},{"key":"e_1_3_9_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-022-01788-5"},{"key":"e_1_3_9_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03056-w"},{"key":"e_1_3_9_18_2","volume-title":"Securing the Future of Precision Medicine for a Cancer-Free Future","author":"Mark Butler MP","year":"2025","unstructured":"Mark Butler MP: Securing the Future of Precision Medicine for a Cancer-Free Future. Australian Government: Department of Health, Disability and Ageing, 2025. https:\/\/www.health.gov.au\/ministers\/the-hon-mark-butler-mp\/media\/securing-the-future-of-precision-medicine-for-a-cancer-free-future"},{"key":"e_1_3_9_19_2","volume-title":"Whole Genome Sequencing Becomes Clinical Routine for all Cases of Pediatric Cancer","author":"Fedric M\u00f6ller Eklund","year":"2024","unstructured":"Fedric M\u00f6ller Eklund: Whole Genome Sequencing Becomes Clinical Routine for all Cases of Pediatric Cancer. Karolinska University Hospital, 2024. https:\/\/www.karolinskahospital.com\/news\/whole-genome-sequencing-becomes-clinical-routine-for-all-cases-of-pediatric-cancer-at-karolinska-university-hospital\/"},{"key":"e_1_3_9_20_2","volume-title":"The government provides significant new funding to Genomic Medicine Sweden to strengthen precision medicine","author":"Genomic Medicine Sweden","year":"2025","unstructured":"Genomic Medicine Sweden: The government provides significant new funding to Genomic Medicine Sweden to strengthen precision medicine, 2025. https:\/\/genomicmedicine.se\/en\/2025\/04\/14\/the-government-provides-significant-new-funding-to-genomic-medicine-sweden-to-strengthen-precision-medicine\/"},{"key":"e_1_3_9_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-021-02759-7"},{"key":"e_1_3_9_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2021.4536"},{"key":"e_1_3_9_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2016.01.008"},{"key":"e_1_3_9_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38142"},{"key":"e_1_3_9_25_2","article-title":"Precision oncology: A global perspective on implementation and policy development","author":"Horgan D","unstructured":"Horgan D, Tanner M, Aggarwal C, et al: Precision oncology: A global perspective on implementation and policy development. JCO Glob Oncol 10.1200\/GO-24-00416","journal-title":"JCO Glob Oncol"},{"key":"e_1_3_9_26_2","volume-title":"Spanish Science, Technology and Innovation Strategy 2021-2027","author":"Ministry of Science and Innovation","year":"2020","unstructured":"Ministry of Science and Innovation: Spanish Science, Technology and Innovation Strategy 2021-2027, 2020. https:\/\/www.ciencia.gob.es\/InfoGeneralPortal\/documento\/1f4e85ac-9e50-49b4-a978-6c15a5195c88"},{"key":"e_1_3_9_27_2","volume-title":"Plan Estrat\u00e9gico: Infraestructura de Medicina de Precisi\u00f3n Asociada a La Ciencia y La Tecnolog\u00eda","author":"IMPaCT-Instituto de Salud Carlos III","year":"2024","unstructured":"IMPaCT-Instituto de Salud Carlos III: Plan Estrat\u00e9gico: Infraestructura de Medicina de Precisi\u00f3n Asociada a La Ciencia y La Tecnolog\u00eda, 2024. https:\/\/impact.isciii.es\/wp-content\/uploads\/2024\/11\/Plan-Estrategico-IMPaCT.pdf"},{"key":"e_1_3_9_28_2","volume-title":"El ISCIII dedica cerca de 30M\u20ac a 46 proyectos de investigaci\u00f3n en medicina de precisi\u00f3n","author":"Ministry of Science and Innovation","year":"2021","unstructured":"Ministry of Science and Innovation: El ISCIII dedica cerca de 30M\u20ac a 46 proyectos de investigaci\u00f3n en medicina de precisi\u00f3n, 2021. https:\/\/www.ciencia.gob.es\/Noticias\/2021\/Diciembre\/El-ISCIII-dedica-cerca-de-30M-a-46-proyectos-de-investigacion-en-medicina-de-precision.html"},{"key":"e_1_3_9_29_2","volume-title":"Cat\u00e1logo Com\u00fan de Pruebas Gen\u00e9ticas y Gen\u00f3micas del SNS","author":"Ministerio de Sanidad","year":"2023","unstructured":"Ministerio de Sanidad: Cat\u00e1logo Com\u00fan de Pruebas Gen\u00e9ticas y Gen\u00f3micas del SNS. Gobierno de Espa\u00f1a, 2023. https:\/\/cgen.sanidad.gob.es\/#\/"},{"key":"e_1_3_9_30_2","volume-title":"Sanidad pone en marcha el cat\u00e1logo com\u00fan de pruebas gen\u00e9ticas","author":"La Moncloa, Ministry of the Presidency","year":"2024","unstructured":"La Moncloa, Ministry of the Presidency: Sanidad pone en marcha el cat\u00e1logo com\u00fan de pruebas gen\u00e9ticas, 2024. https:\/\/www.lamoncloa.gob.es\/serviciosdeprensa\/notasprensa\/sanidad14\/paginas\/2024\/230124-sanidad-catalogo-pruebas-geneticas.aspx"},{"key":"e_1_3_9_31_2","volume-title":"Muchas comunidades aut\u00f3nomas suspenden en pruebas gen\u00e9ticas, todav\u00eda","author":"IM M\u00e9dico","year":"2025","unstructured":"IM M\u00e9dico: Muchas comunidades aut\u00f3nomas suspenden en pruebas gen\u00e9ticas, todav\u00eda, 2025. https:\/\/www.immedicohospitalario.es\/noticia\/49758\/muchas-comunidades-autonomas-suspenden-en-pruebas-geneticas-todavi.html"},{"key":"e_1_3_9_32_2","article-title":"Cat\u00e1logo Com\u00fan de Pruebas Gen\u00e9ticas: una herramienta con evidencia cient\u00edfica para impulsar la equidad en el SNS","author":"Sebasti\u00e1n N","year":"2024","unstructured":"Sebasti\u00e1n N: Cat\u00e1logo Com\u00fan de Pruebas Gen\u00e9ticas: una herramienta con evidencia cient\u00edfica para impulsar la equidad en el SNS. Revista Espa\u00f1ola de Econom\u00eda en Salud, 2024. https:\/\/economiadelasalud.com\/topics\/difusion\/catalogo-comun-de-pruebas-geneticas-una-herramienta-con-evidencia-cientifica-para-impulsar-la-equidad-en-el-sns\/","journal-title":"Revista Espa\u00f1ola de Econom\u00eda en Salud"},{"key":"e_1_3_9_33_2","volume-title":"European Observatory Health Policy Series","author":"Bernal-Delgado E","year":"2024","unstructured":"Bernal-Delgado E, Angulo-Pueyo E, Ridao-L\u00f3pez M, et al: Spain: Health system review. Health systems in transition. Vol 26, in Hern\u00e1ndez-Quevedo C, MaressoA (eds): European Observatory Health Policy Series. Copenhagen (Denmark), European Observatory on Health Systems and Policies, 2024"},{"key":"e_1_3_9_34_2","volume-title":"Implantaci\u00f3 Del Programa d\u2019oncologia de Precisi\u00f3 En El Sistema Sanitari P\u00fablic de Catalunya","author":"Servei Catal\u00e0 de la Salut","year":"2022","unstructured":"Servei Catal\u00e0 de la Salut: Implantaci\u00f3 Del Programa d\u2019oncologia de Precisi\u00f3 En El Sistema Sanitari P\u00fablic de Catalunya, 2022. https:\/\/scientiasalut.gencat.cat\/bitstream\/handle\/11351\/5692\/catsalut_instruccio_03_2021.pdf"},{"key":"e_1_3_9_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-025-04022-9"},{"key":"e_1_3_9_36_2","volume-title":"El Ministerio de Sanidad aprueba la creaci\u00f3n de las especialidades de Gen\u00e9tica M\u00e9dica y Gen\u00e9tica de Laboratorio","author":"Ministry of Health, Government of Spain","year":"2024","unstructured":"Ministry of Health, Government of Spain: El Ministerio de Sanidad aprueba la creaci\u00f3n de las especialidades de Gen\u00e9tica M\u00e9dica y Gen\u00e9tica de Laboratorio, 2024. https:\/\/www.sanidad.gob.es\/gabinete\/notasPrensa.do?id=6697&utm_source=chatgpt.com"},{"key":"e_1_3_9_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-023-03338-8"}],"container-title":["JCO Precision Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/PO-26-00074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T19:59:11Z","timestamp":1788292751000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/PO-26-00074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":36,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1200\/PO-26-00074"],"URL":"https:\/\/doi.org\/10.1200\/po-26-00074","relation":{},"ISSN":["2473-4284"],"issn-type":[{"value":"2473-4284","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-15","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2600074"}}