{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T20:30:06Z","timestamp":1783542606906,"version":"3.55.0"},"reference-count":18,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"7","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Precis Oncol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"\n PURPOSE<\/jats:title>\n Precision medicine has revolutionized oncology; however, tumor biomarkers are not reflective of the heterogeneous cancer population. We evaluated NRG Oncology prostate cancer (PCa) clinical trials for demographic differences among patients with optional biospecimen collection (BC) consent and biospecimen submission (BSub).<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n \n Data from 19 NRG PCa clinical trials closed before 2015 were analyzed. Patients who consented to BC and completed BSub were evaluated by race, ethnicity, median income, area deprivation index (ADI; categorized as highest\n v<\/jats:italic>\n lowest three quartiles), age at enrollment, site, and year of enrollment. T\/chi-square tests were used for continuous\/categorical variables, respectively, followed by logistic regression.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n Of the 15,648 randomized patients eligible for BC, 11,796 (75%) had specimens submitted. In all, 4,598 (82.2%) of 5,597 eligible patients consented for optional BC in nine clinical trials with a separate BC consent process (consent rates by race\/ethnicity: 74.1% Black, 72.8% Hispanic\/Latino, 83.8% White). A smaller proportion of Black and Hispanic\/Latino patients consented to optional BC compared with those who did not (12.1%\n v<\/jats:italic>\n 19.5% Black,\n P<\/jats:italic>\n < .0001; 3.5%\n v<\/jats:italic>\n 5.8% Hispanic,\n P<\/jats:italic>\n = .0006). In univariable logistic regression models, high ADI (more socioeconomic disadvantage) was associated with a decreased likelihood for optional BC consent (odds ratio [OR], 0.67 [95% CI, 0.55 to 0.82];\n P<\/jats:italic>\n = .02), but not a decreased likelihood for BSub (OR, 0.74 [95% CI, 0.53 to 1.04];\n P<\/jats:italic>\n = .08). Multivariable models demonstrated that Black\/Hispanic\/Latino patients were less likely to consent to optional BC, and Black patients were less likely to have BSub (\n P<\/jats:italic>\n < .05 for all).\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n White\/non-Hispanic patients and those with less socioeconomic disadvantage were more likely to consent to optional BC, whereas Black patients were less likely to have BSub. Targeted solutions are needed to improve biorepository representation so that precision medicine approaches better reflect the cancer population.<\/jats:p>\n <\/jats:sec>","DOI":"10.1200\/po-26-00158","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T19:59:12Z","timestamp":1783540752000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Participant Heterogeneity in the Prostate Cancer Biobank of the NRG: An Obstacle to Broadening the Reach of Precision Oncology"],"prefix":"10.1200","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9283-6515","authenticated-orcid":true,"given":"Sophia C.","family":"Kamran","sequence":"first","affiliation":[{"name":"Massachusetts General Hospital Cancer Center, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Borges","sequence":"additional","affiliation":[{"name":"NRG Oncology Statistics and Data Management Center, Philadelphia, PA"},{"name":"American College of Radiology, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0563-3766","authenticated-orcid":true,"given":"Jeff","family":"Michalski","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine, Saint Louis, MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3545-0170","authenticated-orcid":true,"given":"W. Robert","family":"Lee","sequence":"additional","affiliation":[{"name":"Duke University Medical Center, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8193-5769","authenticated-orcid":true,"given":"Howard M.","family":"Sandler","sequence":"additional","affiliation":[{"name":"Cedars-Sinai Medical Center, Los Angeles, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0711-3318","authenticated-orcid":true,"given":"Juanita","family":"Crook","sequence":"additional","affiliation":[{"name":"BCCA-Cancer Centre for the Southern Interior, Kelowna, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1801-2865","authenticated-orcid":true,"given":"Alan","family":"Pollack","sequence":"additional","affiliation":[{"name":"University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.","family":"Hurwitz","sequence":"additional","affiliation":[{"name":"New York Medical College, Valhalla, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard K.","family":"Valicenti","sequence":"additional","affiliation":[{"name":"University of California Davis Comprehensive Cancer Center, Sacramento, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5770-9948","authenticated-orcid":true,"given":"Deborah Watkins","family":"Bruner","sequence":"additional","affiliation":[{"name":"Emory University Hospital\/Winship Cancer Institute, Atlanta, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Himanshu","family":"Lukka","sequence":"additional","affiliation":[{"name":"McMaster University, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8880-5636","authenticated-orcid":true,"given":"Christopher U.","family":"Jones","sequence":"additional","affiliation":[{"name":"Sutter Medical Center Sacramento, Sacramento, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3546-8565","authenticated-orcid":true,"suffix":"III","given":"Mack","family":"Roach","sequence":"additional","affiliation":[{"name":"UCSF Medical Center-Mount Zion, San Francisco, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Lawton","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin, Milwaukee, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth A.","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Pisansky","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Spratt","sequence":"additional","affiliation":[{"name":"Case Western Reserve University, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Vapiwala","sequence":"additional","affiliation":[{"name":"University of Pennsylvania\/Abramson Cancer Center, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0996-0350","authenticated-orcid":true,"given":"Jason","family":"Efstathiou","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Cancer Center, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3692-8823","authenticated-orcid":true,"given":"David","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Cancer Center, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent","family":"Mouw","sequence":"additional","affiliation":[{"name":"Dana-Farber\/Harvard Cancer Center, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4612-7341","authenticated-orcid":true,"given":"Melissa","family":"Vyfhuis","sequence":"additional","affiliation":[{"name":"UM Baltimore Washington Medical Center\/Tate Cancer Center, Glen Burnie, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3682-1439","authenticated-orcid":true,"given":"Quynh-Thu","family":"Le","sequence":"additional","affiliation":[{"name":"Stanford Cancer Institute Palo Alto, Stanford, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Willers","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Cancer Center, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0201-4444","authenticated-orcid":false,"given":"Eliezer","family":"Van Allen","sequence":"additional","affiliation":[{"name":"Dana-Farber\/Harvard Cancer Center, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklin","family":"Huang","sequence":"additional","affiliation":[{"name":"UCSF Medical Center-Parnassus, San Francisco, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5019-4826","authenticated-orcid":true,"given":"Jean-Paul","family":"Bahary","sequence":"additional","affiliation":[{"name":"CHUM - Centre Hospitalier de l'Universite de Montreal, Montreal, 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