{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T11:22:23Z","timestamp":1762341743251,"version":"3.40.5"},"reference-count":45,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"5","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Precision Oncology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec><jats:title>PURPOSE<\/jats:title><jats:p> To investigate the association between tumor volume growth rate after the nadir and survival in patients with EGFR-mutant advanced non\u2013small-cell lung cancer (NSCLC) treated with erlotinib. <\/jats:p><\/jats:sec><jats:sec><jats:title>MATERIALS AND METHODS<\/jats:title><jats:p> Seventy-one patients with EGFR-mutant advanced NSCLC treated with erlotinib were studied for computed tomography tumor volume kinetics during therapy. The tumor growth rate after nadir was obtained using a previously published analytic module for longitudinal volume tracking to study its relationship with overall survival (OS). <\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p> The median tumor volume for the cohort was 19,842 mm<jats:sup>3<\/jats:sup> at baseline and 4,083 mm<jats:sup>3<\/jats:sup> at nadir. The median time to nadir was 6.2 months. The tumor growth rate after nadir for log<jats:sub>e<\/jats:sub>V (the natural logarithm of tumor volume measured in mm<jats:sup>3<\/jats:sup>) was 0.11\/mo on average for the cohort (SE: 0.014), which was very similar to the previously validated reference value of 0.12\/mo to define slow and fast tumor growth. The OS of 48 patients with slow tumor growth (\u2264 0.12\/mo) was significantly longer compared with 23 patients with fast tumor growth (&gt; 0.12\/mo; median OS: 37.8 v 25.0 months; P = .0012). In Cox models, tumor growth rate was also associated with survival (regression coefficient: 3.9903; P = .0024; faster rate leads to increased hazards), after adjusting for time to nadir (regression coefficient: \u20130.0863; P = .0008; longer time to nadir leads to decreased hazards) and smoking history. <\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p> In patients with EGFR-mutant advanced NSCLC treated with erlotinib, slower tumor growth rates after nadir were associated with longer OS, providing a rationale for using tumor growth rates to guide precision therapy for lung cancer. <\/jats:p><\/jats:sec>","DOI":"10.1200\/po.21.00172","type":"journal-article","created":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T19:59:50Z","timestamp":1634241590000},"page":"1603-1610","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":5,"title":["Tumor Growth Rate After Nadir Is Associated With Survival in Patients 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