{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:53:06Z","timestamp":1753883586581,"version":"3.41.2"},"reference-count":32,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"7","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Precision Oncology"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1200\/po.22.00442","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T20:59:11Z","timestamp":1677531551000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":2,"title":["Precision Management of a Patient With Dihydropyrimidine Dehydrogenase Deficiency and Liver-Predominant Metastatic Rectal Cancer Using Hepatic Arterial Floxuridine"],"prefix":"10.1200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4173-5567","authenticated-orcid":false,"given":"Melissa","family":"Lumish","sequence":"first","affiliation":[{"name":"Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1135-5723","authenticated-orcid":false,"given":"Jennifer","family":"Thackray","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6554-0310","authenticated-orcid":false,"given":"Richard Kinh Gian","family":"Do","sequence":"additional","affiliation":[{"name":"Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly E.","family":"Caudle","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital Memphis, TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0880-456X","authenticated-orcid":false,"given":"Ursula","family":"Amstutz","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9984-075X","authenticated-orcid":false,"given":"Matthias","family":"Schwab","sequence":"additional","affiliation":[{"name":"Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany"},{"name":"Department of Clinical Pharmacology, University Hospital, T\u00fcbingen, Germany"},{"name":"Departments of Clinical Pharmacology, and of Biochemistry and Pharmacy, University Hospital, T\u00fcbingen, Germany"},{"name":"Cluster of Excellence iFIT (EXC 2180), \u201cImage-Guided and Functionally Instructed Tumor Therapies,\u201d University of Tuebingen, Tuebingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9648-9570","authenticated-orcid":false,"given":"Robert B.","family":"Diasio","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology and Experimental Therapeutics and Mayo Clinic Cancer Center, Mayo Clinic, Rochester, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William R.","family":"Jarnagin","sequence":"additional","affiliation":[{"name":"Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5054-8192","authenticated-orcid":false,"given":"Andrea","family":"Cercek","sequence":"additional","affiliation":[{"name":"Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","reference":[{"doi-asserted-by":"publisher","key":"b1","DOI":"10.2217\/pgs.11.72"},{"volume-title":"Common Terminology Criteria for Adverse Events (CTCAE) v5.0","year":"2017","author":"U.S. Department of Health and Human Services","key":"b2"},{"doi-asserted-by":"publisher","key":"b3","DOI":"10.1016\/S1470-2045(15)00286-7"},{"doi-asserted-by":"publisher","key":"b5","DOI":"10.1007\/BF01799841"},{"doi-asserted-by":"publisher","key":"b6","DOI":"10.1172\/JCI118830"},{"doi-asserted-by":"publisher","key":"b7","DOI":"10.1371\/journal.pone.0004003"},{"volume-title":"CPIC\u00ae Guideline for Fluoropyrimidines and DPYD\u2014CPIC","key":"b8"},{"doi-asserted-by":"publisher","key":"b9","DOI":"10.1097\/00008571-200004000-00002"},{"doi-asserted-by":"publisher","key":"b10","DOI":"10.1200\/JCO.2006.10.4182"},{"doi-asserted-by":"publisher","key":"b11","DOI":"10.1002\/cpt.685"},{"key":"b12","first-page":"4705","volume":"6","author":"van Kuilenburg AB","year":"2000","journal-title":"Clin Cancer Res"},{"doi-asserted-by":"publisher","key":"b13","DOI":"10.1158\/1078-0432.CCR-04-1784"},{"key":"b14","first-page":"768","volume":"8","author":"Johnson MR","year":"2002","journal-title":"Clin Cancer Res"},{"doi-asserted-by":"publisher","key":"b15","DOI":"10.1042\/bj3640157"},{"doi-asserted-by":"publisher","key":"b16","DOI":"10.1038\/s41431-019-0540-0"},{"key":"b18","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1055\/a-1346-4382","volume":"146","author":"J\u00e4ger S","year":"2021","journal-title":"Dtsch Med Wochenschr"},{"doi-asserted-by":"publisher","key":"b19","DOI":"10.1016\/S1470-2045(18)30686-7"},{"doi-asserted-by":"publisher","key":"b20","DOI":"10.1200\/JCO.2015.63.1325"},{"volume-title":"NCCN Guidelines Version 2.2022 Colon Cancer","year":"2022","author":"Benson AB","key":"b21"},{"doi-asserted-by":"publisher","key":"b22","DOI":"10.1097\/FPC.0b013e32833c6107"},{"year":"2011","author":"PharmGKB","journal-title":"Fluoropyrimidine pathway, pharmacokinetics","key":"b23"},{"volume-title":"Dihydropyrimidine Dehydrogenase (DPD) Gene Mutation Analysis|Test Detail|Quest Diagnostics","key":"b24"},{"doi-asserted-by":"publisher","key":"b25","DOI":"10.1007\/PL00008711"},{"doi-asserted-by":"publisher","key":"b26","DOI":"10.1016\/S1470-2045(20)30555-6"},{"doi-asserted-by":"publisher","key":"b27","DOI":"10.1200\/JCO.2003.03.142"},{"volume-title":"Floxuridine\u2014FUDR\u00ae\u2014GlobalRPH","key":"b28"},{"key":"b29","volume-title":"USP DI \u00ae Volume I, Drug Information for the Health Care Professional","volume":"1","author":"Thomson PDR, Micromedex","year":"2004"},{"volume-title":"Tissue Expression of TK1\u2014Summary\u2014The Human Protein Atlas","key":"b30"},{"volume-title":"American Hospital Formulary Service\u2014Drug Information 2003","year":"1995","author":"McEvoy GK","key":"b31"},{"doi-asserted-by":"publisher","key":"b32","DOI":"10.1053\/j.gastro.2007.08.075"},{"key":"b33","first-page":"172","volume":"10","author":"Ma T","year":"2004","journal-title":"World J Gastroenterol"},{"key":"b34","first-page":"3784","volume":"38","author":"Ensminger WD","year":"1978","journal-title":"Cancer Res"}],"container-title":["JCO Precision Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/PO.22.00442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T20:59:32Z","timestamp":1677531572000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/PO.22.00442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1200\/PO.22.00442"],"URL":"https:\/\/doi.org\/10.1200\/po.22.00442","relation":{},"ISSN":["2473-4284"],"issn-type":[{"type":"electronic","value":"2473-4284"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"2022-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-30","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2200442"}}