{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T07:15:51Z","timestamp":1775978151224,"version":"3.50.1"},"reference-count":80,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"7","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Precis Oncol"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec><jats:title>PURPOSE<\/jats:title><jats:p> To review the literature exploring endometrial cancer (EC) risk among surgical candidates with germline BRCA1\/2 pathogenic variants (PVs) to guide decisions around risk-reducing (rr) hysterectomy in this population. <\/jats:p><\/jats:sec><jats:sec><jats:title>DESIGN<\/jats:title><jats:p> A comprehensive review was conducted of the current literature that influences clinical practice and informs expert consensus. We present our understanding of EC risk among BRCA1\/2 PV carriers, the risk-modifying factors specific to this patient population, and the available research technology that may guide clinical practice in the future. Limitations of the existing literature are outlined. <\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p> Patients with BRCA1\/2 PVs, those with a personal history of tamoxifen use, those who desire long-term hormone replacement therapy, and\/or have an elevated BMI are at higher risk of EC, primarily endometrioid EC and\/or uterine papillary serous carcinoma, and may benefit from rr-hysterectomy. Although prescriptive clinical guidelines specific to BRCA1\/2 PV carriers could inform decisions around rr-hysterectomy, limitations of the current literature prevent more definitive guidance at this time. A large population-based study of a contemporary cohort of BRCA1\/2 PV carriers with lifetime follow-up compared with cancer-gene negative controls would advance this topic and facilitate care decisions. <\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p> This review validates a potential role for rr-hysterectomy to address EC risk among surgical candidates with BRCA1\/2 PVs. Evidence-based clinical guidelines for rr-hysterectomy in BRCA1\/2 PV carriers are essential to ensure equitable access to this preventive measure, supporting insurance coverage for patients with either BRCA1 or BRCA2 PVs to pursue rr-hysterectomy. Overall, this review highlights the complexity of EC risk in BRCA1\/2 PV carriers and offers a comprehensive framework to shared decision making to inform rr-hysterectomy for BRCA1\/2 PV carriers. <\/jats:p><\/jats:sec>","DOI":"10.1200\/po.23.00290","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T20:59:39Z","timestamp":1701982779000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":8,"title":["Endometrial Cancer Risk Among Germline <i>BRCA1<\/i>\/<i>2<\/i> Pathogenic Variant Carriers: Review of Our Current Understanding and Next Steps"],"prefix":"10.1200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3025-4250","authenticated-orcid":false,"given":"Kimia","family":"Sorouri","sequence":"first","affiliation":[{"name":"Medical Oncology, Dana-Farber Cancer Institute, Boston, MA"},{"name":"Harvard Medical School, Boston, 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